TIG - Our Pillars of Therapeutic Immunology

Search within Therapeutic Immunology Group Web Site:

TIG/TAC Index

TIG - Our Bibliography of Therapeutic Immunology

Here is a selection of publications from our group, with links to PDF file downloads, that you might find useful:

Cobbold,S.P., Jayasuriya,A., Nash,A., Prospero,T.D., & Waldmann,H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312, 548-551 (1984) PDF file.

Cobbold,S.P., Martin,G., Qin,S., & Waldmann,H. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature 323, 164-166 (1986) PDF file.

Qin, S., Cobbold, S., Bemjamin, R., & Waldmann, H. Induction of classical transplantation tolerance in the adult. J. Exp. Med. 169, 779-794 (1989). PDF file.

Mathieson, P.W., Cobbold, S.P., Hale, G., Clark, M.R., Oliviera, D.B.G., Lockwood, C.M., and Waldmann, H. Monoclonal antibody therapy in systemic vasculitis. New Engl. J. Med., 323, 250-254 (1990). PDF file.

Qin, S., Wise, M., Cobbold, S.P., Leong, L., Kong, Y.M., Parnes, J.R., & Waldmann, H. Induction of tolerance in peripheral T-cells with monoclonal antibodies. Eur. J. Immunol. 20, 2737-2745 (1990). PDF file.

Isaacs, J.D., Watts, R.A., Hazleman, B.L., Hale, G., Keogan, M.T., Cobbold, S.P., and Waldmann, H. Humanised monoclonal antibody therapy for rheumatoid arthritis. Lancet, 240, 748-752 (1992) PDF file.

Qin, S., Cobbold, S.P., Pope, H., Elliott, J., Kioussis, D., & Waldmann, H. "Infectious" transplantation tolerance. Science, 259, 974-977 (1993).PDF file.

Davies, J.D., Leong, L.Y.W., Mellor, A., Cobbold, S.P. and Waldmann, H. T cell suppression in transplantation tolerance through linked recognition. J. Immunol., 156: 3602-3607 (1996) PDF file.

Hale G, Zhang MJ, Bunjes D, Prentice HG, Spence D, Horowitz MM, Barrett AJ, Waldmann H. Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection. Blood. 1998 Dec 15;92(12):4581-90. PDF file.

Zelenika, D., Adams, E., Mellor, A., Simpson, E., Chandler, P., Stockinger, B., Waldmann, H., & Cobbold, S. P. Rejection of H-Y disparate skin grafts by monospecific CD4+ helper 1 (Th1) and T helper 2 (Th2) cells; no requirement for CD8+ T cells or B cells. J. Immunol. 161:1868-1874 (1998). PDF file.

Zelenika, D., Adams, E. Humm, S., Graca, L., Thompson, S., Cobbold, S*., Waldmann, H*. (*joint senior authors) Regulatory T cells over-express a subset of Th2 gene transcripts J. Immunol. 168: 1069-1079 (2002)PDF file.

Graca, L., Cobbold, SP., and Waldmann, H. Identification of regulatory T cells in tolerated allografts. J. Exp. Med. 195(12): 1641-1646 (2002) PDF file.

Lin, C-Y., Graca, L., Cobbold, SP., Waldmann, H. Dominant transplantation tolerance impairs CD8+ T cell function but not expansion. Nature Immunology 3(12): 1208-1213 (2003)PDF file.

Tone, M., Tone, Y., Adams, E., Yates, SF., Frewin, M., Cobbold, SP., Waldmann, H. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc. Natl. Acad. Sci. USA. 100 (25): 15059-15064 (2003). PDF file.

Cobbold, SP., Castejon, R., Adams, E., Zelenika, D., Graca, L., Humm, S., Waldmann, H. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J. Immunol. 172: 6003-6010-5907 (2004). PDF file.

Winsor-Hines D, Merrill C, O'Mahony M, Rao PE, Cobbold SP, Waldmann H, Ringler DJ, Ponath PD Induction of Immunological Tolerance/Hyporesponsiveness in Baboons with a Nondepleting CD4 Antibody. J. Immunol. 173: 4715-4723 (2004). PDF file.

Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S, Schandene L, Crenier L, De Block C, Seigneurin JM, De Pauw P, Pierard D, Weets I, Rebello P, Bird P, Berrie E, Frewin M, Waldmann H, Bach JF, Pipeleers D, Chatenoud L. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med. 352(25):2598-608. (2005). PDF file.

Cobbold SP, Adams E, Graca L, Daley S, Yates S, Paterson A, Robertson NJ, Nolan KF, Fairchild PJ, Waldmann H. Immune privilege induced by regulatory T cells in transplantation tolerance. Immunol Rev. 213:239-55. Review. (2006). PDF file.

Yates SF, Paterson AM, Nolan KF, Cobbold SP, Saunders NJ, Waldmann H, Fairchild PJ. Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation. J Immunol. 179(2):967-76. (2007). PDF file.

Daley SR, Ma J, Adams E, Cobbold SP, Waldmann H. A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts. J Immunol. 179(6):3648-54. (2007). PDF file.

Robertson NJ, Brook FA, Gardner RL, Cobbold SP, Waldmann H, Fairchild PJ. Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance. Proc Natl Acad Sci U S A. 104(52):20920-5. (2007). PDF file.

CAMMS223 Trial Investigators, Coles AJ, Compston DA, Selmaj KW, Lake SL, Moran S, Margolin DH, Norris K, Tandon PK. Alemtuzumab vs. Interferon beta-1a in early multiple sclerosis. N Engl J Med. 359(17):1786-801. (2008). PDF file.

Cobbold, SP., Adams, E., Farquhar, CA., Nolan, KF., Howie, D., Lui, KO., Fairchild, PJ., Mellow, AL., Ron, D., Waldmann, H. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12055-60. PDF file.

"Developing short-term treatments for long-term outcomes"