![Transcription factories in a Hela cell [from Cook PR (1999) Science 284, 1790]](../images/pombo.png)
Harris, H., and Cook, P.R. (1969). Synthesis of an enzyme determined by an erythrocyte nucleus in a hybrid cell. J. Cell Sci. 5, 121-134. [PubMed] [pdf]
Cook, P.R. (1970). Species specificity of an enzyme determined by an erythrocyte nucleus in an interspecific hybrid cell. J. Cell Sci. 7, 1-3. [PubMed] [pdf]
Cook, P.R. (1970). ‘Studies on differentiation in vertebrate cells’. A thesis presented for the degree of Doctor of Philosophy in the University of Oxford. [pdf of Abstract]
Schwartz, A.G., Cook, P.R., and Harris, H. (1971). Correction of a genetic defect in a mammalian cell. Nature, New Biol. 230, 5-8. [PubMed] [pdf]
Miller, O.J., Cook, P.R., Khan, P. M., Shin, S., and Siniscalco, M. (1971). Mitotic separation of two human X-linked genes in man-mouse somatic cell hybrids. Proc. Natl. Acad. Sci. U.S.A. 68, 116-120. [PubMed] [pdf]
Cook, P.R. (1971). Insertion of small pieces of foreign genetic material into somatic cells. Biochem. J. 124, 35P-37P. [PubMed] [pdf]
Shin, S., Khan, P. M., and Cook, P.R. (1971). Characterisation of hypoxanthine-guanine phosphoribosyl transferase in man-mouse somatic cell hybrids by an improved electrophoretic method. Biochem. Genet. 5, 91-99. [PubMed] [pdf]
Cook, P.R. (1973). Hypothesis on differentiation and the inheritance of gene superstructure. Nature 245, 23-25. [PubMed] [pdf]
Cook, P.R. (1974). On the inheritance of differentiated
traits. Biol. Rev. 49, 51-84. [pdf]
Cook, P.R. (1975). Linkage of
the loci for glucose-6-phosphate dehydrogenase and for inosinic acid
pyrophosphorylase to the X chromosome of the field-vole Microtus
agrestis. J. Cell Sci. 17, 95-112. [PubMed] [pdf]
Cook, P.R., and Brazell, I.A. (1975). Supercoils in human DNA. J. Cell Sci. 19, 261-279. [PubMed] [pdf]
Cook, P.R., and Brazell, I.A. (1976). Conformational constraints in nuclear DNA. J. Cell Sci. 22, 287-302. [PubMed] [pdf]
Cook, P.R., Brazell, I.A., and Jost, E. (1976). Characterization of nuclear structures containing superhelical DNA. J. Cell Sci. 22, 303-324. [PubMed] [pdf]
Cook, P.R., and Brazell, I.A. (1976). Detection and repair of single-strand breaks in nuclear DNA. Nature 263, 679-682. [PubMed] [pdf]
Cook, P.R., and Brazell, I.A. (1977). The superhelical density of nuclear DNA from human cells. Eur. J. Biochem. 74, 527-531. [PubMed] [pdf]
Cook, P.R., and Brazell, I.A. (1977). Supercoils in nuclear DNA and the repair of radiation damage. Mut. Res. 46, 111-112.
Colman, A., and Cook, P.R. (1977). Transcription of superhelical DNA from cell nuclei. Eur. J. Biochem. 76, 63-78. [PubMed] [pdf]
Levin, J.M., Jost, E., and Cook, P.R. (1978). The dissociation of nuclear proteins from superhelical DNA. J. Cell Sci. 29, 103-116. [PubMed] [pdf]
Cook, P.R., Brazell, I.A., Pawsey, S.A., and Giannelli, F. (1978). Changes induced by ultraviolet light in the superhelical DNA of lymphocytes from subjects with xeroderma pigmentosum and normal controls. J. Cell Sci. 29, 117-127. [PubMed] [pdf]
Cook, P.R., and Brazell, I.A. (1978). Spectrofluorometric measurement of the binding of ethidium to superhelical DNA from cell nuclei. Eur. J. Biochem. 84, 465-477. [PubMed] [pdf]
Warren, A.C., and Cook, P.R. (1978). Supercoiling of DNA and nuclear conformation during the cell cycle. J. Cell Sci. 30, 211-226. [PubMed] [pdf]
McCready, S.J., Akrigg, A., and Cook, P.R. (1979). Electron microscopy of intact nuclear DNA from human cells. J. Cell Sci. 39, 53-62. [PubMed] [pdf]
Akrigg, A., and Cook, P.R. (1980). DNA gyrase stimulates transcription. Nucl. Acids Res. 8, 845-854. [PubMed] [pdf]
Cook, P.R., and Brazell, I.A. (1980). Mapping sequences in loops of nuclear DNA by their progressive detachment from the nuclear cage. Nucl. Acids Res. 8, 2895-2906. [PubMed] [pdf]
McCready, S.J., Godwin, J., Mason, D.W., Brazell, I.A., and Cook, P.R. (1980). DNA is replicated at the nuclear cage. J. Cell Sci. 46, 365-386. [PubMed] [pdf]
Levin, J.M., and Cook, P.R. (1981). Conformational changes induced by salt in complexes of histones and superhelical nuclear DNA. J. Cell Sci. 50, 199-208. [PubMed] [pdf]
Levin, J.M., and Cook, P.R. (1981). Reconstruction of complexes of histones and superhelical nuclear DNA. J. Cell Sci. 50, 209-224. [PubMed] [pdf]
Jackson, D.A., McCready, S.J., and Cook, P.R. (1981). RNA is synthesised at the nuclear cage. Nature 292, 552-555. [PubMed] [pdf]
McCready, S.J., Jackson, D.A., and Cook, P.R. (1982). Attachment of superhelical DNA to the nuclear cage during replication and transcription. Prog. Mut. Res. 4, 113-130. [pdf]
Jackson, D.A., Caton, A.J., McCready S.J., and Cook, P.R. (1982). Influenza virus RNA is synthesised at fixed sites in the nucleus. Nature 296, 366-368. [PubMed] [pdf]
Cook, P.R. Lang, J., Hayday, A., Lania, L., Fried, M., Chiswell, D.J., and Wyke, J.A. (1982). Active viral genes in transformed cells lie close to the nuclear cage. EMBO J. 1, 447-452. [PubMed] [pdf]
Jackson, D.A., and Patel, S.B. (1982). Nuclear organization - does the sub-structure play a crucial role? Trends Biochem. Sci. 7, 272-274.
Patel, S.B., and Cook, P.R. (1983). The DNA-protein cross: a method for detecting specific DNA-protein complexes in crude mixtures. EMBO J. 2, 137-142. [PubMed] [pdf]
Cook, P.R., and Lang, J. (1984). The spatial organization of sequences involved in initiation and termination of eukaryotic DNA replication. Nucl. Acids Res. 12, 1069-1075. [PubMed] [pdf]
Cook, P.R. (1984). A general method for isolating intact nuclear DNA. EMBO J. 3, 1837-1842. [PubMed] [pdf]
McCready, S.J., and Cook, P.R. (1984). Lesions induced in DNA by ultra-violet light are repaired at the nuclear cage. J. Cell Sci. 70, 189-196. [PubMed] [pdf]
Jackson, D.A., Patel, S.B., and Cook, P.R. (1984). Attachment of repeated sequences to the nuclear cage. Nucl. Acids Res. 12, 6709-6726. [PubMed] [pdf]
Jackson, D.A., McCready, S.J., and Cook, P.R. (1984). Replication and transcription depend on attachment of DNA to the nuclear cage. J. Cell Sci. Suppl. 1, 59-79. [PubMed] [pdf]
Cook, P.R., and Laskey, R.A. (editors), (1984). 'Higher order structure in the nucleus'. Proceedings of the First British Society for Cell Biology - Company of Biologists Symposium held in Manchester, April, 1984. J. Cell Sci. Suppl. 1.
Dyson, P.J., Cook, P.R., Searle, S., and Wyke, J.A. (1985). The chromatin structure of Rous sarcoma proviruses is changed by factors that act in trans in cell hybrids. EMBO J. 4, 413-420. [PubMed] [pdf]
McCready, S.J., and Cook, P.R. (1985). Unscheduled DNA synthesis takes place at the nuclear cage. Br. J. Cancer 51, 604.
Jackson, D.A., and Cook, P.R. (1985). A general method for preparing chromatin containing intact DNA. EMBO J. 4, 913-918. [PubMed] [pdf]
Jackson, D.A., and Cook, P.R. (1985). Transcription occurs at a nucleoskeleton. EMBO J. 4, 919-925. [PubMed] [pdf]
Jackson, D.A., and Cook, P.R. (1986). Replication occurs at a nucleoskeleton. EMBO J. 5, 1403-1410. [PubMed] [pdf]
Whittaker, J., Lang, J., Cook, P.R., Aspinall, S., McCready, S.J., and Cox, B.S. (1986). Part of the human ribosomal RNA locus stabilizes a plasmid in yeast. Nucl. Acids Res. 14, 5683-5692. [PubMed] [pdf]
Jackson, D.A., and Cook, P.R. (1986). A cell-cycle dependent DNA polymerase activity that replicates intact DNA in chromatin. J. Mol. Biol. 192, 65-76. [PubMed] [pdf]
Jackson, D.A., and Cook, P.R. (1986). Different populations of DNA polymerase α in Hela cells. J. Mol. Biol. 192, 77-86. [PubMed] [pdf]
Jackson, D.A. (1986). Nucleoids. In 'Nuclear Structures: isolation and characterization' pp 14-33. Ed. MacGillivray A.J., and Birnie G.D. Butterworths, London.
Jackson, D.A. (1986). Organization beyond the gene. Trends Biochem. Sci. 11, 249-252.
Jackson, D.A., and Cook, P.R. (1987). The nucleoskeleton: active site of transcription and replication. In 'Modern Trends in Human Leukemia VII', edited by Neth, R., Gallo, R.C., Greaves, M.F., and Kabisch, H., pp 299-303, Springer-Verlag, Berlin. Also published as Jackson, D.A., and Cook, P.R. (1987). The nucleoskeleton: active site of transcription and replication. Haematol. Blood Transfus. 31, 299-303. [PubMed] [pdf]
Cook, P.R., and Jackson, D.A. (1988). The nucleoskeleton: active site of transcription or artifact? In 'Chromosomes and Chromatin' Vol. III, edited by Adolph, K.W., pp 97-118, CRC Press, Baton Rouge, Florida. [pdf]
Cook, P.R. (1988). The nucleoskeleton: artefact, passive framework or active site? J. Cell Sci. 90, 1-6. [PubMed] [pdf]
Jackson, D.A., Yuan, J., and Cook, P.R. (1988). A gentle method for preparing cyto- and nucleo-skeletons and associated chromatin. J. Cell Sci. 90, 365-378. [PubMed] [pdf]
Jackson, D.A., and Cook, P.R. (1988). Visualization of a filamentous nucleoskeleton with a 23 nm axial repeat. EMBO J. 7, 3667-3677. [PubMed] [pdf]
Dear, P.H., and Cook, P.R. (1989). Happy mapping: a proposal for linkage mapping the human genome. Nucl. Acids Res. 17, 6795-6807. [PubMed] [pdf]
Cook, P.R. (1989). The nucleoskeleton and the topology of transcription. Eur. J. Biochem. 185, 487-501. [PubMed] [pdf]
Jackson, D.A., Pearson, C.K., Fraser, D.C., Prise, K.M., and Wong, S. Y. (1989). Methotrexate-induced morphological changes mimic those seen after heat-shock. J. Cell Sci. 92, 37-49. [PubMed]
Briggs, D., Jackson, D., Whitelaw, E., and Proudfoot, N.J. (1989). Direct demonstration of termination signals for RNA polymerase II from the sea urchin H2A histone gene. Nucl. Acids Res. 17, 8061-8071.
Jackson, D.A., Dickinson, P., and Cook, P.R. (1990). The size of chromatin loops in HeLa cells. EMBO J. 9, 567-571. [PubMed] [pdf]
Cook, P.R. (1990). How mobile are active RNA polymerases? J. Cell Sci. 96, 189-192. [PubMed] [pdf]
Dickinson, P., Cook, P.R., and Jackson, D.A. (1990). Active RNA polymerase I is fixed within the nucleus of HeLa cells. EMBO J. 9, 2207-2214. [PubMed] [pdf]
Jackson, D.A., Dickinson, P., and Cook, P.R. (1990). Attachment of DNA to the nucleoskeleton of HeLa cells examined using physiological conditions. Nucl. Acids Res. 18, 4385-4393. [PubMed] [pdf]
Jackson, D.A. (1990). The organization of replication centres in higher eukaryotes. BioEssays 12, 87-89. [PubMed]
Jackson, D.A. (1990). Does butylphenyl-deoxyguanosine triphosphate differentially inhibit DNA polymerase a and d activities in permeabilised HeLa cells? Nucl. Acids Res. 18, 753-758. [PubMed]
Dear, P.H., and Cook, P.R. (1991). Cellular gels: purifying and mapping long DNA molecules. Biochem. J. 273, 695-699. [PubMed] [pdf]
Cook, P.R. (1991). The nucleoskeleton and the topology of replication. Cell 66, 627-635. [PubMed] [pdf]
Jackson, D.A. (1991). Structure-function relationships in eukaryotic nuclei. BioEssays 13, 1-10. [PubMed]
Mullins, S.T., Annan, N.K., Cook, P.R.., and Lowe, G. (1992). Bis-intercalators of DNA with a rigid linker in an extended configuration. Biochemistry 31, 842-849. [PubMed] [pdf]
Annan, N.K., Cook, P.R., Mullins, S.T.., and Lowe, G. (1992). Evidence for cross-linking DNA by bis-intercalators with rigid and extended linkers is provided by knotting and catenation. Nucl. Acids Res. 20, 983-990. [PubMed] [pdf]
Cook, P.R., and Gove, F. (1992). Transcription by an immobilized RNA polymerase from bacteriophage T7 and the topology of transcription. Nucl. Acids Res. 20, 3591-3598. [PubMed] [pdf]
Jackson, D.A., Dolle, A., Robertson, G., and Cook, P.R. (1992). The attachments of chromatin loops to the nucleoskeleton. Cell Biol. Int. Rep. 16, 687-696. [PubMed] [pdf]
Cook, P.R. (1993). A model for reverse transcription by a dimeric enzyme. J. Gen. Virol. 74, 691-697. Corrigendum 74, 3037. [PubMed] [pdf]
Dear, P.H., and Cook, P.R. (1993). Happy mapping: linkage mapping using a physical analogue of meiosis. Nucl. Acids Res. 21, 13-20. [PubMed] [pdf]
Hozák, P., Hassan, A.B., Jackson, D.A., and Cook, P.R. (1993). Visualization of replication factories attached to a nucleoskeleton. Cell 73, 361-373. [PubMed] [pdf]
Jackson, D.A., Hassan, A.B., Errington, R.J., and Cook, P.R. (1993). Visualization of focal sites of transcription within human nuclei. EMBO J. 12, 1059-1065. [PubMed] [pdf]
Cook, P.R., Dolle, A., Hassan, A.B., Hozák, P., and Jackson, D.A. (1993). The role of the nucleoskeleton in RNA metabolism. Nucl. Acids Mol. Biol. 7, 226-237. [pdf]
Hassan, A.B., and Cook, P.R. (1993). Visualization of replication sites in unfixed human cells. J. Cell Sci. 105, 541-550. [PubMed] [pdf]
Jackson, D.A., and Cook, P.R. (1993). Transcriptionally-active minichromosomes are attached transiently in nuclei through transcription units. J. Cell Sci. 105, 1143-1150. [PubMed] [pdf]
Hassan, A.B., and Jackson, D.A. (1993). Chromatin structure and nuclear function. In ‘Molecular biology for clinical oncologists’ (Ed. Yarnold, J., Stratton, M., and McMillan T.), pp 287-298. Elsevier Science Publishers, Amsterdam, The Netherlands.
Hozák, P., and Cook, P.R. (1994). Replication factories. Trends Cell Biol. 4, 48-52. [PubMed] [pdf]
Cook, P.R. (1994). Transcription by immobile RNA polymerases. In ‘The legacy of cell fusion’. Ed. S. Gordon. Oxford University Press, Oxford. pp 84-100. [pdf]
Hassan, A.B., Errington, R.J., White, N.S., Jackson, D.A., and Cook. P.R. (1994). Replication and transcription sites are colocalized in human cells. J. Cell Sci. 107, 425-434. [PubMed] [pdf]
Hozák, P., Cook, P.R., Schöfer, C., Mosgöller, W., and Wachtler, F. (1994). Site of transcription of ribosomal RNA and intra-nucleolar structure in HeLa cells. J. Cell Sci. 107, 639-648. [PubMed] [pdf]
Hassan, A.B., and Cook, P.R. (1994). Does transcription by RNA polymerase play a direct role in the initiation of replication? J. Cell Sci. 107, 1381-1387. [PubMed] [pdf]
Cook, P.R. (1994). RNA polymerase: structural determinant of the chromatin loop and the chromosome. BioEssays 16, 425-430. [PubMed] [pdf]
Jackson, D.A., Balajee, A.S., Mullenders, L., and Cook, P.R. (1994). Sites in human nuclei where DNA damaged by ultra-violet light is repaired: visualization and localization relative to the nucleoskeleton. J. Cell Sci. 107, 1745-1752. [PubMed] [pdf]
Jackson, D.A., Hassan, A.B., Errington, R.J., and Cook, P.R. (1994). Sites in human nuclei where damage induced by ultra-violet light is repaired: localization relative to transcription sites and concentrations of proliferating cell nuclear antigen and the tumour suppressor protein, p53. J. Cell Sci. 107, 1753-1760. [PubMed] [pdf]
Hozák, P., Jackson, D.A., and Cook, P.R. (1994). Replication factories and nuclear bodies: the ultrastructural characterization of replication sites during the cell cycle. J. Cell Sci. 107, 2191-2202. [PubMed] [pdf]
Hassan, A.B., and Prové, G.P. (1994). Making image copies. Microscopy and Analysis, 40, 17.
Jackson, D.A. (1994). The nuclear matrix. In ‘The Encyclopedia of Molecular Biology’, p 749-754, Blackwells, Oxford.
Hozák, P., Sasseville, A. M-J., Raymond, R., and Cook. P.R. (1995). Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells. J. Cell Sci. 108, 635-644. [PubMed] [pdf]
Jackson, D.A., and Cook, P.R. (1995). The structural basis of nuclear function. Int. Rev. Cytol. 162A, 125-149. [PubMed] [pdf]
Cook, P.R. (1995). A chromomeric model for nuclear and chromosome structure. J. Cell Sci. 108, 2927-2935. [PubMed] [pdf]
Hughes, T.A., Pombo, A., McManus, J., Hozák, P., Jackson, D.A., and Cook, P.R. (1995). On the structure of replication and transcription factories. J. Cell Sci., Suppl. 19, 59-65. [PubMed] [pdf]
McManus, J., Hughes, T.A., Pombo, A., Jones, E.., Iborra, F.J., Jackson, D.A., and Cook, P.R. (1995). ‘Nuclear factories for replication, transcription and repair.’ In Proceedings of the 10th International Congress of Radiation Research. Radiation Research 1985-1995, Congress Proceedings 2, 352-361. [pdf]
Jackson, D.A. (1995). Nuclear organization: uniting replication foci, chromatin domains and chromosome structure. BioEssays 17, 587-591. [PubMed]
Jackson, D.A. (1995). S-phase progression in synchronized human cells. Exp. Cell. Res. 220, 62-70. [PubMed]
Hozák, P., Jackson, D.A., and Cook. P.R. (1996). The role of nuclear structure in DNA replication. In 'Eukaryotic DNA replication: frontiers in molecular biology' (Ed. J.J. Blow), pp124-142. Oxford University Press, Oxford. [pdf]
Iborra, F.J., Pombo, A., Jackson, D.A., and Cook, P.R. (1996). Active RNA polymerases are localized within discrete transcription 'factories' in human nuclei. J. Cell Sci. 109, 1427-1436. [PubMed] [pdf] Corrigendum published in Iborra, F.J., Jackson, D.A., and Cook, P.R. (1998). J. Cell Sci. 111, 2269-2282.
Hughes, T.A., and Cook, P.R. (1996). Mimosine arrests the cell cycle after cells enter S-phase. Exp. Cell Res. 222, 275-280. [PubMed] [pdf]
Jackson, D.A., Bartlett, J., and Cook, P.R. (1996). Sequences attaching loops of nuclear and mitochondrial DNA to underlying structures in human cells: the role of transcription units. Nucl. Acids Res. 24, 1212-1219. [PubMed] [pdf]
Carpenter, M.L., Lowe, G., and Cook, P.R. (1996). The structure of 4-way DNA junctions: specific binding of bis-intercalators with rigid linkers. Nucl. Acids Res. 24, 1594-1601. [PubMed] [pdf]
McCoubrey, A., Latham, H.C., Cook, P.R., Rodger, A., and Lowe, G. (1996). 4-Picoline-2,2':6',2''-terpyridine-platinum (II) - a potent intercalator of DNA. FEBS Letters 380, 73-78. [PubMed] [pdf]
Iborra, F.J., Pombo, A., McManus, J., Jackson, D.A., and Cook, P.R. (1996). The topology of transcription by immobilized polymerases. Exp. Cell Res. 229, 167-173. [PubMed] [pdf]
Pombo, A., and Cook, P.R. (1996). The localization of sites containing nascent RNA and splicing factors. Exp. Cell Res. 229, 201-203. [PubMed] [pdf]
Pombo, A., McManus, J., Hughes, T.A., Iborra, F.J., Jackson, D.A., and Cook, P.R. (1996). Transcription factories and chromosome structure. Chromosomes Today 12, 147-160. [pdf]
Cook, P.R. (1997). The transcriptional basis of chromosome pairing. J. Cell Sci. 110, 1033-1040. [PubMed] [pdf]
Jackson, D.A. (1997). Chromatin domains and nuclear compartments: establishing sites of gene expression in eukaryotic nuclei. Mol. Biol. Reports. 24, 209-220. [PubMed]
Iborra, F., Pombo, A., and Jackson, D.A. (1997). Dedicated sites of gene expression in the nuclei of mammalian cells. Gene Ther. Mol. Biol. 1, 495-508.
Pombo, A., Cuello, P., Schul, W., Yoon, J.-B., Roeder, R.G., Cook, P.R., and Murphy, S. (1998). Regional and temporal specialization in the nucleus: a transcriptionally-active nuclear domain rich in PTF, Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle. EMBO J. 17, 1768-1778. [PubMed] [pdf]
Jackson, D.A., and Cook, P.R. (1998). Analyzing DNA replication: non-isotopic labeling. In 'Cells: a laboratory manual', pp 109.1-109.13. Edited by D.L. Spector, R.D. Goldman and L.A. Leinwand. Cold Spring Harbor Laboratory Press, NY. Republished as three distinct sections: [pdf1] [pdf2] [pdf3]
Jackson, D.A., and Cook, P.R. (1998). Analyzing RNA synthesis: non-isotopic labeling. In 'Cells: a laboratory manual', pp 110.1-110.10. Edited by D.L. Spector, R.D. Goldman and L.A. Leinwand. Cold Spring Harbor Laboratory Press, NY. [pdf]
Jackson, D.A., Iborra, F.J., Manders, E.M.M., and Cook, P.R. (1998). Numbers and organization of RNA polymerases, nascent transcripts and transcription units in HeLa nuclei. Mol. Biol. Cell 9, 1523-1536. [PubMed] [pdf] Erratum published in Mol. Biol. Cell 9, 2698.
Iborra, F.J., Jackson, D.A., and Cook, P.R. (1998). The path of transcripts from extra-nucleolar synthetic sites to nuclear pores: transcripts in transit are concentrated in discrete structures containing SR proteins. J. Cell Sci. 111, 2269-2282. [PubMed] [pdf]
Iborra, F.J., and Cook, P.R. (1998). The size of sites containing SR proteins in human nuclei: problems associated with characterizing small structures by immunogold labelling. J. Histochem. Cytochem. 46, 985-992. [PubMed] [pdf]
Cook, P.R. (1998). Duplicating a tangled genome. Science 281,
1466-1467. [pdf]
Jackson, D.A., and Pombo, A. (1998). Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S-phase in human cells. J. Cell Biol. 140, 1285-1295. [PubMed]
Wykes, M., Pombo, A., Jenkins, C., and MacPherson, G.G. (1998). Dendritic cells interact with naive B lymphocytes to transfer antigen and initiate class-switching in a primary T-dependent response. J. Immunol. 161, 1313-1319. [PubMed]
McDowell, T.L., Gibbons, R.J., O'Rourke, D., Sutherland, H., Bickmore, W.A., Pombo, A., Turley, H., Gatter, K., Picketts, D., Buckle, V.J., Chapman, L., Rhodes, D., and Higgs, D.R. (1999). Localization of a putative transcriptional regulator (ATRX) at pericentric heterochromatin and the tips of acrocentric chromosomes. Proc. Natl. Acad. Sci. USA 96, 13983-13988. [PubMed]
Pombo, A., Hollinshead, M., and Cook, P.R. (1999). Bridging the resolution gap: imaging the same transcription factories in cryosections by light and electron microscopy. J. Histochem. Cytochem. 47, 471-480. [PubMed] [pdf]
Manders, E.M.M., Kimura, H., and Cook, P.R. (1999). Direct imaging of DNA in living cells reveals the dynamics of chromosome formation. J. Cell Biol. 144, 813-822. [PubMed] [pdf] [Supporting information: movie of chromosome condensation]
Pombo, A., Jackson, D.A., Hollinshead, M., Wang, Z., Roeder, R.G., and Cook, P.R. (1999). Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III. EMBO J. 18, 2241-2253. [PubMed] [pdf]
Kimura, H., Tao, Y., Roeder, R.G., and Cook, P.R. (1999). Quantitation of RNA polymerase II and its transcription factors in an HeLa cell: little soluble holoenzyme but significant amounts of polymerases attached to the nuclear substructure. Mol. Cell. Biol. 19, 5383-5392. [PubMed] [pdf]
Cook, P.R. (1999). The organization of replication and transcription. Science 284, 1790-1795. [PubMed] [pdf]
Jackson, D.A. (1999). Analyzing the substructure of mammalian nuclei, in vitro. In 'Chromosome structural analysis: a practical approach' (W.A. Bickmore, ed), pp 147-166. Oxford University Press, Oxford.
Iborra, F.J., Jackson, D.A., and Cook, P.R. (2000). Transport of mRNA through nuclear pores: apparent entry from the sides into dedicated pores. J. Cell Sci. 113, 291-302. [PubMed] [pdf]
Jones, E., Kimura, H., Vigneron, M., Wang, Z., Roeder, R.G. and Cook, P.R. (2000). Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. Exp. Cell Res. 254, 163-172. [PubMed] [pdf]
Pombo, A., Jones, E., Iborra, F.J., Kimura, H., Sugaya, K., Cook, P.R., and Jackson, D.A. (2000). Specialized transcription factories within mammalian nuclei. Crit. Rev. Eukaryotic Gene Exp. 10, 21-29. [PubMed] [pdf]
Sugaya, K., Vigneron, M., and Cook, P.R. (2000). Mammalian cell lines expressing functional RNA polymerase II tagged with the green fluorescent protein. J. Cell Sci. 113, 2679-2683. [PubMed] [pdf]
Wade-Martins, R., White, R.E., Kimura, H., Cook, P.R., and James, M.R. (2000). Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kbp genomic transgene. Nature Biotechnology 18, 1311-1314. [PubMed] [pdf]
Jackson, D.A., Pombo, A., and Iborra, F.J. (2000). The balance sheet for transcription: an analysis of nuclear RNA metabolism in mammalian cells. FASEB J. 14, 242-254. [PubMed]
Kenny, E., Mason, D., Pombo, A., Ramirez, F. (2000). Phenotypic analysis of peripheral CD4+ CD8+ T cells in the rat. Immunology 101, 178-184. [PubMed]