Transcription factories in a Hela cell [from Cook PR (1999) Science 284, 1790]

Nuclear Structure and Function Research Group

Model for all genomes Welcome to the Cook group (contacts).

Movie: This 5-min YouTube movie shows how we think an RNA polymerase works, how genes are regulated, and how the genome is organized.


'Transcription factories': a comprehensive review.


News: Extraordinary results on translation. Human cells are pulse-labeled with tagged amino acids for 5-300 s; both nucleus and cytoplasm are labeled, and most signal disappears with a half-life of <60 s.

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