Steve Cobbold's Publications

Listed with most recent publications first

Howie D, Waldmann H, Cobbold SP.
Nutrient sensing via mTOR in T cells maintains a tolerogenic microenvironment.
Frontiers in Immunology; August 2014, Volume 5, Article 409
Piotti G, Ma J, Adams E, Cobbold S, Waldmann H.
Guiding postablative lymphocyte reconstitution as a route toward transplantation tolerance.
Am J Transplant. 2014 Jul;14(7):1678-89.
Waldmann H, Hilbrands R, Howie D, Cobbold S.
Harnessing FOXP3+ regulatory T cells for transplantation tolerance.
J Clin Invest. 2014 Apr 1;124(4):1439-45.
Cobbold SP.
The mTOR pathway and integrating immune regulation.
Immunology. 2013 Dec;140(4):391-8.
Hilbrands R, Howie D, Cobbold S, Waldmann H.
Regulatory T cells and transplantation tolerance.
Immunotherapy. 2013 Jul;5(7):717-31.
Cobbold SP, Waldmann H.
Regulatory cells and transplantation tolerance.
Cold Spring Harb Perspect Med. 2013 Jun 1;3(6). pii: a015545.
Regateiro FS, Cobbold SP, Waldmann H.
CD73 and adenosine generation in the creation of regulatory microenvironments.
Clin Exp Immunol. 2013 Jan;171(1):1-7.
Cobbold SP, Li XC.
Translating Tolerogenic Therapies to the Clinic - Where Do We Stand and What are the Barriers?
Front Immunol. 2012;3:317. doi:10.3389/fimmu.2012.00317.
Regateiro FS, Chen Y, Kendal AR, Hilbrands R, Adams E, Cobbold SP, Ma J, Andersen KG, Betz AG, Zhang M, Madhiwalla S, Roberts B, Waldmann H, Nolan KF, Howie D.
Foxp3 expression is required for the induction of therapeutic tissue tolerance.
J Immunol. 2012 Oct 15;189(8):3947-56.
Agorogiannis EI, Regateiro FS, Howie D, Waldmann H, Cobbold SP.
Th17 cells induce a distinct graft rejection response that does not require IL-17A.
Am J Transplant. 12(4):835-45.
Regateiro FS, Cobbold SP, Waldmann H
CD73 and adenosine generation in the creation of regulatory microenvironments
Clinical and Experimental Immunology DOI: 10.1111/j.1365-2249.2012.04623.x
Kendal AR, Chen Y, Regateiro FS, Ma J, Adams E, Cobbold SP, Hori S, Waldmann H.
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.
J Exp Med. Aug 29. doi: 10.1084/jem.20110767
Regateiro FS, Howie D, Cobbold SP, Waldmann H.
TGF-ß in transplantation tolerance.
Curr Opin Immunol. 2011 Aug 10.
Regateiro FS, Howie D, Nolan KF, Agorogiannis EI, Greaves DR, Cobbold SP, Waldmann H.
Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-ß.
Eur J Immunol. Jul 19. doi: 10.1002/eji.201141512.
McIntosh, J., Cochrane, M., Cobbold, S., Waldmann, H., Davidoff, AM., Nathwani, AC.
Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV mediated gene transfer with a non-depleting CD4 antibody and cyclosporine.
Gene Ther. Jun 30. doi: 10.1038/gt.2011.64.
Cobbold SP, Adams A and Waldmann H
Biomarkers of transplantation tolerance: more hopeful than helpful?
Front. Immun. 2:9. doi: 10.3389/fimmu.2011.00009
Cobbold SP.
Rejecting minors--it's all in the presentation.
Transplantation. 2011 Jan 27;91(2):152-3. PubMed PMID: 21079548.
Peter C, Waldmann H, Cobbold SP.
mTOR signalling and metabolic regulation of T cell differentiation.
Curr Opin Immunol. 2010 Sep 10. [Epub ahead of print] PubMed PMID: 20833524.
Lui KO, Boyd AS, Cobbold SP, Waldmann H, Fairchild PJ.
A Role for Regulatory T Cells in Acceptance of Embryonic Stem Cell-Derived Tissues Transplanted Across an MHC Barrier.
Stem Cells. 2010 Aug 24. [Epub ahead of print] PubMed PMID: 20737577.
Cobbold, SP., Adams, E., Nolan, KF., Regateiro, FS., and Waldmann, H.
Connecting the mechanisms of T cell regulation: dendritic cells as the missing link.
Immunological Reviews 236:203-218.
Condamine T, Le Texier L, Howie D, Lavault A, Hill M, Halary F, Cobbold S, Waldmann H, Cuturi MC, Chiffoleau E.
Tmem176B and Tmem176A are associated with the immature state of dendritic cells.
J Leukoc Biol. 2010 May 28. [Epub ahead of print] PubMed PMID: 20501748.
Farquhar CA, Paterson AM, Cobbold SP, Garcia Rueda H, Fairchild PJ, Yates SF, Adams E, Saunders NJ, Waldmann H, Nolan KF.
Tolerogenicity is not an absolute property of a dendritic cell.
Eur J Immunol. 2010 Jun;40(6):1728-37. PubMed PMID: 20373289.
Cobbold, SP.
Combining regulation with suppression and aiming for tolerance.
Transplantation. 2010 Apr 27;89(8):909-10. PubMed PMID: 20216484.
You S, Poulton L, Cobbold S, Liu CP, Rosenzweig M, Ringler D, Lee WH, Segovia B, Bach JF, Waldmann H, Chatenoud L.
Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.
PLoS One. 2009 Nov 20;4(11):e7848.
Howie D, Nolan KF, Daley S, Butterfield E, Adams E, Garcia-Rueda H, Thompson C, Saunders NJ, Cobbold SP, Tone Y, Tone M, Waldmann H.
MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation.
J Immunol. 2009 Oct 1;183(7):4197-204. Epub 2009 Sep 14.
Cobbold, SP., Adams, E., Farquhar, CA., Nolan, KF., Howie, D., Lui, KO., Fairchild, PJ., Mellow, AL., Ron, D., Waldmann, H.
Infectious tolerance via the consumption of essential amino acids and mTOR signaling.
Proc Natl Acad Sci U S A. Epub 2009 June 30. doi:10.1073/pnas.0903919106.
Link to full version of the paper (Open Access).
Campbell JD, Buckland KF, McMillan SJ, Kearley J, Oldfield WL, Stern LJ, Grönlund H, van Hage M, Reynolds CJ, Boyton RJ, Cobbold SP, Kay AB, Altmann DM, Lloyd CM, Larché M.
Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression.
J Exp Med. 2009 Jun 15. [Epub ahead of print] PubMed PMID: 19528258.
Cobbold, SP.
Future therapeutics for the induction of peripheral immune tolerance to autoimmune disease and organ transplantation.
Immunotherapy 1 (3): 447-460.
Waldmann H, Cobbold S.
Regulatory T cells: context matters
Immunity 30, May22; 2009: 613-615.
Li Z, Benghiat FS, Charbonnier LM, Kubjak C, Rivas MN, Cobbold SP, Waldmann H, De Wilde V, Petein M, Schuind F, Goldman M, Le Moine A.
CD8+ T-Cell Depletion and Rapamycin Synergize with Combined Coreceptor/Stimulation Blockade to Induce Robust Limb Allograft Tolerance in Mice.
Am J Transplant. 2008 Oct 6. [Epub ahead of print]
Daley SR, Cobbold SP, Waldmann H.
Fc-disabled anti-mouse CD40L antibodies retain efficacy in promoting transplantation tolerance.
Am J Transplant. 2008 Nov;8(11):2265-71. Epub 2008 Sep 8.
Waldmann H, Adams E, Fairchild P, Cobbold SP.
Regulation and Privilege in Transplantation Tolerance.
J Clin Immunol. 2008 Sep 6. [Epub ahead of print]
Cobbold SP.
Regulatory T cells and transplantation tolerance.
J Nephrol. 2008 Jul-Aug;21(4):485-96. Review.
Waldmann H, Adams E, Cobbold SP.
Reprogramming the immune system: co-receptor blockade as a paradigm for harnessing tolerance mechanisms.
Immunol Rev. 2008 Jun;223:361-70.
Robertson NJ, Brook FA, Gardner RL, Cobbold SP, Waldmann H, Fairchild PJ.
Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance.
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20920-5. Epub 2007 Dec 18.
Nolan KF, Cobbold SP, Waldmann H.
SAGE analysis of cell types involved in tolerance induction.
Methods Mol Biol. 2007;380:225-51.
Daley SR, Ma J, Adams E, Cobbold SP, Waldmann H.
A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts.
J Immunol. 2007 Sep 15;179(6):3648-54.
Yates SF, Paterson AM, Nolan KF, Cobbold SP, Saunders NJ, Waldmann H, Fairchild PJ.
Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation.
J Immunol. 179(2):967-76.
Senis YA, Tomlinson MG, Garcia A, Dumon S, Heath VL, Herbert J, Cobbold SP, Spalton JC, Ayman S, Antrobus R, Zitzmann N, Bicknell R, Frampton J, Authi KS, Martin A, Wakelam MJ, Watson SP.
A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein.
Mol Cell Proteomics. 6(3):548-64.
Cobbold SP, Adams E, Graca L, Daley S, Yates S, Paterson A, Robertson NJ, Nolan KF, Fairchild PJ, Waldmann H.
Immune privilege induced by regulatory T cells in transplantation tolerance.
Immunol Rev. 213:239-55.
Waldmann H, Adams E, Fairchild P, Cobbold S.
Infectious tolerance and the long-term acceptance of transplanted tissue.
Immunol Rev. 2006 Aug;212:301-13.
Cobbold S.
The hidden truth about gene expression in Tregs: Is it what you don't see that counts?
Eur J Immunol. 36(6):1360-3.
Graca L, Daley S, Fairchild PJ, Cobbold S, Waldmann H.
Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning.
BMC Immunol. Apr 25;7:9.
Neujahr DC, Chen C, Huang X, Markmann JF, Cobbold S, Waldmann H, Sayegh MH, Hancock WW, Turka LA.
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it.
J Immunol. 176(8):4632-9.
Waldmann H, Chen TC, Graca L, Adams E, Daley S, Cobbold S, Fairchild PJ.
Regulatory T cells in transplantation.
Semin Immunol. 18(2):111-9.
Cobbold SP.
T cell tolerance induced by therapeutic antibodies.
Philos Trans R Soc Lond B Biol Sci. 360(1461):1695-705.
Metcalfe SM, Calne RY, Cobbold SP.
Introduction: immunoregulation: harnessing T cell biology for therapeutic benefit.
Philos Trans R Soc Lond B Biol Sci. 360(1461):1641-3.
Waldmann H, Graca L, Adams E, Fairchild P, Cobbold S.
Regulatory T cells in transplantation tolerance.
Curr Top Microbiol Immunol. 293:249-64.
Morrison J, Palmer DB, Cobbold S, Partridge T, Bou-Gharios G.
Effects of T-lymphocyte depletion on muscle fibrosis in the mdx mouse.
Am J Pathol. 166(6):1701-10.
You S, Belghith M, Cobbold S, Alyanakian MA, Gouarin C, Barriot S, Garcia C, Waldmann H, Bach JF, Chatenoud L.
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.
Diabetes. 54(5):1415-22.
Graca L, Chen TC, Le Moine A, Cobbold SP, Howie D, Waldmann H.
Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells.
Trends Immunol. 26(3):130-5. Review.
Cobbold SP.
New trends in immunosuppression.
Int Immunopharmacol. 5(1):1-5.
Winsor-Hines D, Merrill C, O'Mahony M, Rao PE, Cobbold SP, Waldmann H, Ringler DJ, Ponath PD
Induction of Immunological Tolerance/Hyporesponsiveness in Baboons with a Nondepleting CD4 Antibody
J. Immunol. 173: 4715-4723. Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Mellor AL, Chandler P, Babak B, Hansen AM, Marshall B, Pihkala J, Waldmann H, Cobbold S, Adams E, Munn D
Specific subsets of murine dendritic cells aquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase.
International Immunology doi:10.1093/intimm/dxh140. PDF online
Waldmann, H., Cobbold, S.
Viewpoint: Exploiting tolerance processes in transplantation
Science 305: 209-212.
Graca L, Le Moine A, Lin CY, Fairchild PJ, Cobbold SP, Waldmann H.
Donor-specific transplantation tolerance: The paradoxical behavior of CD4+CD25+ T cells.
Proc Natl Acad Sci U S A. 101(27):10122-6.
Cobbold, SP.
Monoclonal antibodies as tools to induce immune tolerance.
Kidney International 65: 1541.
Cobbold, SP., Castejon, R., Adams, E., Zelenika, D., Graca, L., Humm, S., Waldmann, H.
Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.
J. Immunol. 172: 6003-6010.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Chen, T-C., Cobbold, SP., Fairchild, PJ., Waldmann, H.
Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen.
J. Immunol. 172: 5900-5907.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Waldmann, H., Graca, L., Cobbold, SP., Adams, E., Tone, M., Tone, Y.
Regulatory T cells and organ transplantation
Seminars in Immunology 16(2): 119-126.
Nolan, KF., Strong, V., Soler, D., Fairchild, PJ., Cobbold, SP., Croxton, R., Gonzalo, J-A., Rubio, A., Wells, M., Waldmann, H.
IL10 conditioned dendritic cells, decomissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals.
J. Immunol. 172(4): 2201-2209.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Tone, M., Tone, Y., Adams, E., Yates, SF., Frewin, M., Cobbold, SP., Waldmann, H.
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells
Proc. Natl. Acad. Sci. USA. 100 (25): 15059-15064.
published online before print.
Cobbold, SP., Nolan, K., Graca, L., Castejon, R., LeMoine, A., Frewin, M., Humm, S., Adams, E., Thompson, S., Zelenika, D., Paterson, A., Yates, S., Fairchild, PJ., Waldmann, H.
Regulatory T cells and Dendritic cells in Transplantation Tolerance: molecular markers and mechanisms.
Immunol. Reviews 196: 109-124.
Graca, L., LeMoine, A., Cobbold, SP., Waldmann, H.
Antibody-induced transplantation tolerance: the role of dominant regulation.
Immunol. Research, 28(3): 181-191.
Graca, L., LeMoine, A., Cobbold SP., Waldmann, H.
Dominant transplantation tolerance.
Curr. Opin. Immunol. 15(5): 499-506.
Cobbold, SP., Adams, E., Graca, L., Waldmann, H.
Serial analysis of gene expression provides new insights into regulatory T cells.
Seminars in Immunology 15(4): 209-214.
Cobbold SP, Graca L, Lin C-Y, Adams E, Waldmann H.
Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance.
Transplant International 16:66-75.
Lin, C-Y., Graca, L., Cobbold, SP., Waldmann, H.
Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.
Nature Immunology 3(12): 1208-1213.
Published online here.
Cobbold, SP.
T cell tolerance in transplantation: possibilities for therapeutic intervention.
Expert Opinions in Therapeutic Targets, 6(5): 583-599.
Graca, L., Cobbold, SP., and Waldmann, H.
Identification of regulatory T cells in tolerated allografts.
J. Exp. Med. 195(12): 1641-1646.
Graca, L., Thompson, S., Lin, C-Y., Adams, E., Cobbold, S., Waldmann H.
Both CD4+CD25+ and CD4+CD25- regulatory cells mediate dominant transplantation tolerance.
J. Immunol. 168(11): 5558-5565.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Zelenika, D., Adams, E. Humm, S., Graca, L., Thompson, S., Cobbold, S*., Waldmann, H*.
*joint senior authors
Regulatory T cells over-express a subset of Th2 gene transcripts
J. Immunol. 168: 1069-1079.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Waldmann, H., Cobbold, SP.
Approaching tolerance in transplantation.
Int. Arch. Allergy Immunol. 126: 11-22.
Waldmann, H., Cobbold, SP., Fairchild, P. and Adams, E.
Therapeutic aspects of tolerance.
Current Opinions in Pharmacology 1: 392-397.
Hale, G., Cobbold, S., Noitzky, N., Bunjes, D., Willemze, R., Prentice, HG., Milligan, D., Mackinnon, S., and Waldmann, H. on behalf of CAMPATH users.
CAMPATH-1 antibodies in stem cell transplantation.
Cytoptherapy 3: 145-164.
Zelenika, D., Adams, E., Humm, S., Lin, C-Y., Waldmann, H. and Cobbold, SP.
The role of CD4+ T cell subsets in determining transplantation rejection or tolerance.
Immunol. Rev. 182: 164-179.
Waldmann, H. and Cobbold, S.
Regulating the immune response to transplants: a role for CD4+ regulatory cells?
Immunity 14: 399-406.
Waldmann, H., Hale, G., Cobbold, S.
Appropriate targets for monoclonal antibodies in the induction of transplantation tolerance.
Phil. Trans. R. Soc. Lond. B, 356: 1-5.
Cobbold, S.
Defective fasL reveals immunoregulation after costimulation blockade (editorial).
Transplantation, 71: 496-7.
Waldmann, H., Cobbold, S., and Hale, G.
Graft versus host disease: its control and prospects for allogeneic bone marrow transplantation.
in Pathology and Immunology of Transplantation and Rejection
Thiru, S., Waldmann, H. (Editors)
Pub: Blackwells Science, Oxford.
pp 438-445.
Waldmann, H., and Cobbold, S.
T-cell regulation and transplantation tolerance.
Current Opinions in Organ Transplantation 5: 83-89.
Graca, L., Honey, K., Adams, EA., Cobbold, SP. and Waldmann, H.
Cutting Edge: Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.
J. Immunol.,165: 4783-4786.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Honey, K., Bemelman, F., Cobbold, S.P., and Waldmann, H.
High dose bone marrow transplantation induces deletion of antigen-specific T cells in a Fas independent manner.
Transplantation, 69(8): 1676-1682.
Honey, K., Cobbold, S.P., and Waldmann, H.
Dominant tolerance and linked suppression induced by therapeutic antibodies do not depend on Fas-FasL interactions.
Transplantation, 69(8):1683-1689.
Wise, M., Cobbold, S. and Waldmann, H.
Tolerance induction with CD4 monoclonal antibodies: a role for minors in linked suppression.
In: Minor Histocopatibility Antigens (Eds Roopenian, D.C. & Simpson, E.) Landis BioScience, Austin, Texas, pp 141-147.
Rebello PR, Hale G, Friend PJ, Cobbold SP, Waldmann H
Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection.
Transplantation 68(9):1417-20.
Honey K, Cobbold SP, Waldmann H
CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression.
J Immunol 163(9):4805-10.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Honey K, Cobbold SP, Waldmann H
Dominant regulation: a common mechanism of monoclonal antibody induced tolerance?
Immunol Res 20(1):1-14
Wise, M., Zelenika, D., Bemelman, F., Latinne, D., Bazin, H., Cobbold, S., and Waldmann, H.
CD4 T cells can reject major histocompatibility complex class I incompatible skin grafts.
Eur. J. Immunol. 29: 156-167.
Zelenika, D., Adams, E., Cobbold, S.P., and Waldmann, H.
British Patent no 9923790.1 applied for (September 1999).
Immunoregulatory compositions.
Waldmann, H., Gilliland, L.K., Cobbold, S.P., and Hale, G.
in Fundamental Immunology, Fourth Edition., Ed. Paul, W.E.,
Lipincott-Raven Publishers, Philadelphia, Chapter 45: 1511-1533.
Wise, M.P., Bemelman, F., Cobbold, S.P., and Waldmann, H.
Linked suppression can operate through indirect recognition.
J. Immunol. 161: 5813-5816.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Stebbings, R., Stott, J., Almond, N., Hull, R., Lines, J., Silvera, P., Sangster, R., Corcoran, T., Jenkins, A., Cobbold, S., Gotch, F., McMichael, A. & Walker, B.
Mechanisms of protection induced by attenuated Simian Immunodeficiency Virus. II. Lymphocyte depletion does not abrogate protection.
AIDS Research and Human Retroviruses, 14: 1187-1198.
Cobbold, S. & Waldmann, H.
Infectious tolerance.
Curr. Opinion Immunol. 10 (5): 518-524.
Zelenika,D., Adams, E., Mellor, A., Simpson, E., Chandler, P., Stockinger, B., Waldmann, H., & Cobbold, S. P.
J. Immunol. 161: 1868-1874 (1998).
Rejection of H-Y disparate skin grafts by monospecific CD4+ T helper 1 (Th1) and T helper 2 (Th2) cells: no requirement for CD8+ T cells or B cells.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Zelenika, D., Cobbold, S.P., and Waldmann, H.
British Patent no 9803154.5 applied for (February 1998 - no longer maintained).
Proteases and tolerance.
Waldmann, H., Bemelman, F., and Cobbold, S.
Tolerance induction with CD4 monoclonal antibodies.
in Immunological Tolerance
Novartis Foundation Symposium 215, 146-158.
pub. Wiley, Chichester.
Waldmann, H., & Cobbold, S.
Ann. Rev. Immunol.16: 619-44 (1998).
How do monoclonal antibodies induce tolerance? A role for Infectious Tolerance?
[Abstract] [Full Text] [PDF]
Bemelman, F., Honey, K., Adams, E., Cobbold, S., & Waldmann, H.
J. Immunol. 160: 2645-2648 (1998).
Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Zelenika, D., Cobbold, S.P., and Waldmann, H.
British Patent no 9720888.8 and International Patents applied for (September 1997).
Davies, J.D., Cobbold, S.P., & Waldmann, H.
Transplantation 63:1570-73 (1997).
Strain variation in susceptibility to monoclonal antibody- induced transplantation tolerance.
Scully, R., Cobbold, S.P., Mellor, A.L., Wissing, M., Arnold, B. & Waldmann, H.
Eur. J. Immunol. 27: 1663-1670. (1997)
A role for Th2 cytokines in the suppression of CD8+ T cell mediated graft rejection.
Chen, Z.K., Cobbold, S.P., Waldmann, H., & Metcalfe, S.
Transplantation 62: 1200-1206 (1996)
Amplification of natural regulatory immune mechanisms for transplantation tolerance.
Marshall, S.E., Cobbold, S.P., Davies, J.D., Martin, G.M., Phillips, J.M., & Waldmann, H.
Transplantation, 62: 1614-1621 (1996)
Tolerance and suppression in a primed immune system.
Cobbold, S.P., Adams, E., Marshall, S.E., Davies, J.D., & Waldmann, H.
Immunol. Rev. 149: 5-33 (1996)
Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8
Davies, J.D., Leong, L.Y.W., Mellor, A., Cobbold, S.P., & Waldmann, H.
J. Immunol., 156: 3602-3607 (1996)
T cell suppression in transplantation tolerance through linked recognition
Davies, J.D., Martin, G., Phillips, J., Marshall, S.E., Cobbold, S.P., & Waldmann, H.
J. Immunol in 157:529-533 (1996)
T cell regulation in adult transplantation tolerance
Friend-PJ; Rebello-P; Oliveira-D; Manna-V; Cobbold-SP; Hale-G; Jamieson-NV; Jamieson-I; Calne-RY; Harris-DT; et-al
Transplant-Proc. 27(1): 869-70 (1995)
Successful treatment of renal allograft rejection with a humanized antilymphocyte monoclonal antibody.
Watson, C.J.E., Cobbold, S.P., Davies, H.ff.S., Rebello, P.R.U.B., Waldmann, H., Calne, R.Y. & Metcalfe, S.M.
Brit. J. Surg. 80, 1389-1392 (1994)
CD4 and CD8 monoclonal antibody therapy: strategies to prolong renal allograft survival in the dog.
Cobbold, S.
in The Encyclopaedia of Molecular Biology Ed. Kendrew, J. & Lawrence, E. (Blackwell Science, Oxford) pp149-155(1994)
CD antigens
Gorman, S., Frewin, M., Cobbold, S. & Waldmann, H.
Tissue Antigens 43, 184-188(1994)
Isolation and expression of cDNA encoding the canine CD4 and CD8a antigens.
Watson, C.J.E., Cobbold, S.P., Davies, H.ff.S., Rebello, P.R.U.B., Thiru, S., McNair, R., Rasmussen, A., Waldmann, H., Calne, R.Y., & Metcalfe, S.M.
Tissue Antigens 43: 155-162 (1994)
Immunosuppression of canine renal allograft recipients by CD4 and CD8 monoclonal antibodies.
Scully, R., Qin,S., Cobbold, S. & Waldmann, H.
Eur. J. Immunol. 24, 2383-2392 (1994)
Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T-cells.
Waldmann, H. & Cobbold, S.
in Lydyard, P.M. & Brostoff, J. (Eds.) Autoimmune disease: aetiopathogenesis, diagnosis and Blackwell Science, Oxford (Pubs.), pp 164-168. treatment.(1994)
Reprogramming the immune system.
Cobbold, S., Holmes, M., and Willett, B.
Immunology Today 15, 347-353(1994)
The immunology of companion animals: reagents and therapeutic strategies with potential veterinary and human clinical applications.
Waldmann, H., Cobbold, S. & Hale, G.
Curr-Opin-Immunol. 6(5): 777-83 . (1994)
What can be done to prevent graft versus host disease?
Cobbold, S. & Metcalfe, S.
Tissue Antigens 43, 137-154 (1994)
Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW).
Chen-Z; Cobbold-SP; Waldmann-H; Metcalfe-SM
Transplant-Proc. 26(3): 1199-200 (1994)
Tolerance induction in concordant heart-xenografted mice by CD4 and CD8 monoclonal antibodies.
Chen-Z; Cobbold-S; Waldmann-H; Metcalfe-S
Transplant-Proc. 26(4): 2433-4 (1994)
Combined use of RS61443 with CD4 and CD8 MAbs to generate tolerance to skin xenografts from rat to mouse.
Wise, M., Benjamin, R., Qin, S., Cobbold, S., and Waldmann, H.
'Molecular mechanisms in immunological self-recognition' Ed. Vogel, H. (Academic Press) 149-155 (1993)
Tolerance induction in the peripheral immune system: tolerance is maintained by CD4 T-cells that 'resist' the activities of normal, naive CD4 T-cells.
Waldmann-H; Qin-S; Cobbold-SP
Immunol-Ser. 59: 85-99 (1993)
Monoclonal antibodies for the therapeutic induction of tolerance.
Qin, S., Cobbold, S.P., Pope, H., Elliott, J., Kioussis, D., & Waldmann, H.
Science, 259, 974-977 (1993)
'Infectious' transplantation tolerance.
Waldmann, H., Qin, S., & Cobbold, S.P.
in Bach, J.F., ed. Monoclonal antibodies and peptide therapy in autoimmune diseases Marcel Dekker. Chapter 5 pp 85-99 (1993)
Monoclonal antibodies for the therapeutic induction of tolerance
Waldmann, H. & Cobbold, S.
Immunology Today 14, 247-251 (1993)
The use of monoclonal antibodies to achieve immunological tolerance
Waldmann, H. & Cobbold, S.
Current Opinion Immunol. 5, 753-758 (1993)
Monoclonal antibodies for the induction of transplantation tolerance
Waldmann-H; Cobbold-S
Trends-Pharmacol-Sci. 14(5): 143-8 (1993)
The use of monoclonal antibodies to achieve immunological tolerance.
Isaacs, J.D., Watts, R.A., Hazleman, B.L., Hale, G., Keogan, M.T., Cobbold, S.P., & Waldmann, H.
Lancet, 240, 748-752 (1992)
Humanised monoclonal antibody therapy for rheumatoid arthritis.
Waldmann, H., Qin, S., Leong, L., & Cobbold, S.P.
Trends in Experimental and Clinical Medicine 2, 250-261. (1992)
In vivo use of monoclonal antibodies for modulation of the immune response.
Leong, L. Y. W., Qin, S., Cobbold, S., and Waldmann, H.
Eur. J. Immunol. 22, 2825-2830 (1992)
Classical Transplantation Tolerance in the adult. II The need for haemopoietic space in classical-type transplantation tolerance in the adult.
Cobbold, S.P., Qin, S., Leong, L.Y.W., Martin, G., & Waldmann, H.
Immunol. Rev. 129, 165-201 (1992)
Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies.
Chen, Z., Cobbold, S.P., Metcalfe, S., and Waldmann, H.
Eur. J. Immunol. 22, 805-810 (1992)
Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8.
Nabozny, G.H., Cobbold, S.P., Waldmann, H. and Kong, Y. M.
Cellular Immunology 138, 185-196 (1991)
Suppression in murine experimental autoimmune thyroiditis: in vivo inhibition of CD4+ T-cell-mediated resistance by a nondepleting rat CD4 monoclonal antibody.
Cobbold. S.P.
Immunol. Lett. 29, 117-122 (1991)
Monoclonal antibody therapy for the induction of transplantation tolerance
Gorman, S.D., Clark, M.R., Routledge, E.G., Cobbold, S.P., & Waldmann, H.
Proc. Natl. Acad. Sci. 88, 4181-4185 (1991)
Reshaping a therapeutic CD4 antibody.
Friend, P.J., Waldmann, H., Cobbold, S., Tighe, H., Rebello, P., Wight, D., Gore, S., Pollard, S., Lim, S., & Johnston, P.
Transplant Proc. 23, 1390-1392 (1991)
The anti-IL-2 receptor monoclonal antibody YTH 906 in liver transplantation.
Friend, P.J., Waldmann, J., Hale, G., Cobbold, S., Rebello, P., Thiru, S., Jamieson, N.V., Johnston, P.S., & Calne, R.Y.
Transplant Proc. 23, 2253-2254 (1991)
Reversal of allograft rejection using the monoclonal antibody, CAMPATH-1G.
Waldmann, H., Cobbold, S., Clark, M., Hale, G., Qin, S., and Wise, M.
Horizons in Medicine (Transmedica, Cambridge University Press) 2, 229-238 (1990)
The generation of immunological tolerance as a therapeutic procedure.
Qin, S., Wise, M., Cobbold, S.P., Leong, L., Kong, Y.M., Parnes, J.R., & Waldmann, H.
Eur. J. Immunol. 20, 2737-2745 (1990)
Induction of tolerance in peripheral T-cells with monoclonal antibodies.
Weiss, L., Weisensberg, M., Morecki, S., Bar, S., Cobbold, S., Waldmann, H., & Slavin, S.
Cancer Immunol. Immunother. 31, 236-242 (1990)
Characterisation of effector cells of graft vs leukaemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukaemia.
Cobbold, S.P., Qin, S. and Waldmann, H.
Seminars in Immunology 2, 377-387 (1990)
Reprogramming the immune system for tolerance with monoclonal antibodies.
Waldmann, H., Hale, G., Cobbold, S., Clark, M., Qin, S., Benjamin, R., & Dyer, M.J.S.
Hematology 12, 277-293 (Ed. Burakoff, S.J., Deeg, H.J., Ferrara, J., and Atkinson, K. Publ. Marcel Dekker Inc N.Y. & Basel) (1990)
Monoclonal antibody therapy for the prevention of graft versus host disease.
Cobbold, S.P., Martin, G., and Waldmann, H.
Eur. J. Immunol. 20, 2747-2755 (1990)
The induction of skingraft tolerance in MHC-mismatched or primed recipients: primed T-cells can be tolerized in the periphery with CD4 and CD8 antibodies.
Cobbold, S.
Res. Immunol. 141/8, 799-800 (1990)
Peripheral tolerance.
Mathieson, P.W., Cobbold, S.P., Hale, G., Clark, M.R., Oliviera, D.B.G., Lockwood, C.M., and Waldmann, H.
New Engl. J. Med., 323, 250-254 (1990)
Monoclonal antibody therapy in systemic vasculitis.
Cobbold, S.P., Rebello, P.R.U.B., Davies, HffS., Friend, P.J., and Clark, M.R.
J. Immunol. Methods 127, 19-24 (1990)
A simple method for measuring patient anti-globulin responses against isotypic or idiotypic determinants.
Cobbold, S.P., Hale, G., Waldmann, H. for CAMPATH users.
Prog. Clin. Biol. Res. 333, 139-151 (1990)
Purging in auto- and allografts: monoclonal antibodies which use human complement and other natural effector mechanisms.
Gorman, S.D., Clark, M.R., Cobbold, S.P., 7 Waldmann, H.
British Patent no 90202823.1 and International Patents applied for.(1990)
Altered antibodies and their preparation
Vignali D.A., Crocker P., Bickle, Q.D., Cobbold S., Waldmann H., Taylor, M.G.
Immunology 67, 466-472 (1989)
A role for CD4+ but not CD8+ T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-3128-terminated infections.
Cobbold, S.P., Barel, D. & Waldmann, H.
in T cells (eds. Feldmann, M., Lamb, J., and Owen, M.J. ), Cell Biology 7, 147 (1989)
Manipulating the immune system with monoclonal antibodies: mouse models for immunotherapy.
Qin, S., Cobbold, S., Bemjamin, R., & Waldmann, H.
J. Exp. Med. 169, 779-794 (1989)
Induction of classical transplantation tolerance in the adult.
Kong, Y.M., Waldmann, H., Cobbold, S., et al.
Clin. Exp. Immunol. 77, 428-433 (1989)
Pathogenic mechanisms in murine autoimmune thyroiditis: short- and long-term effects of in vivo depletion of CD4+ and CD8+ cells.
Kong, Y.M., Giraldo, A.A., Waldmann, H., Cobbold, S.P., & Fuller, B.
Clin. Immunol. Immunopathol. 51, 38-54 (1989)
Resistance to experimental autoimmune thyroiditis: L3T4+ cells as mediators of both thyroglobulin-activated and TSH-induced suppression.
Hale, G., Cobbold, S.P., and Waldmann, H.
Tissue Antigens 33, 363 (1989)
Cluster analysis using percentage or mean fluorescence: comparison indicates that future workshop analysis could be improved and simplified.
Liew, F.Y., Millot, S., Lelchuk, R., Cobbold, S. & Waldmann, H.
Clin. Exp. Immunol. 75, 438-443 (1989)
Effect of CD4 monoclonal antibody in vivo on lesion development, delayed-type hypersensitivity and interleukin 3 production in experimental murine cutaneous leishmaniasis.
Tinois, E., Cobbold, S., Faure, M., Yeoman, H., & Stanley, M.
Eur. J. Immunol., 19, 1031 (1989)
Cultured keratinocyte grafts are recognized, but not rejected by, CD8+ T cells in vivo.
Waldmann, H., Cobbold, S.P., and Qin, S.
Prog. Immunol. 7, 147-155 (1989)
Tolerance induction using CD4 and CD8 monoclonal antibodies.
Day, M.J., Elson, C.J., Cobbold, S.P., and Waldmann, H.
Autoimmunity 3, 39-45 (1989)
Adoptive suppression of erythrocyte autoantibodies in Lyt-2+ depleted recipients.
Waldmann, H., Cobbold, S.P., Qin, S., Benjamin, R.J., and Wise, M.
Cold Spring Harbor Symp. Quant. Biol. 54, 885-892 (1989)
Tolerance induction in the adult using monoclonal antibodies to CD4, CD8 and CD11a (LFA-1).
Waldmann, H., Hale, G., Cobbold, S.P., Clark, M., Qin, S., Benjamin, R., & Dyer, M.S.
Graft versus host disease (ed Burakoff, S.) pub Marcel-Dekker, Hematology 12, 277-293 (1989)
Monoclonal antibody therapy to prevent graft versus host disease.
Clark, M., Bindon, C., Dyer, M., Friend, P., Hale, G., Cobbold, S., Calne, R., & Waldmann, H.
Eur. J. Immunol. 19, 381-388 (1989)
The improved lytic function and in vivo efficacy of monovalent monoclonal CD3 antibodies.
Flynn, J.C., Conaway, D.H., Cobbold, S., Waldmann, H., & Kong, Y.M.
Cell. Immunol. 122, 377-390 (1989)
Depletion of L3T4+ and Lyt-2+ cells by rat monoclonal antibodies alters the development of adoptively transferred experimental autoimmune thyroiditis.
Cobbold, S.P., & Waldmann, H.
British Patent no 8912497.8 and International Patents applied for.(1989)
Monoclonal antibodies for inducing tolerance
Hale,G., Cobbold,S., Waldmann,H. for CAMPATH-1 users.
Transplantation, 45, 753-759 (1988)
T cell depletion with CAMPATH-1 in allogeneic bone marrow transplantation.
Tighe,H., Friend,P.J., Collier,StJ., Decurtins,M., Lim,S., Cobbold,S.P., Thiru,S., Calne,R.Y., Waldmann,H.
Transplantation 45, 226-228 (1988)
Delayed allograft rejection in primates treated with anti-IL2 receptor monoclonal antibody, CAMPATH-6.
Waldmann, H., Cobbold, S., Benjamin, R., & Qin, S.
J. Autoimmunity, 1, 623-629 (1988)
A theoretical framework for self-tolerance and its relevance to therapy of autoimmune disease.
Leist, T.P., Frei, K., Cobbold, S.P. Waldmann, H. & Zinkernagel, R.M.
J.Immunol (1988)
Effect of T cell subset depletion on host resistance to Listeria monocytogenes infections in mice.
Waldmann,H., Hale,G., Clark,M., Cobbold,S., Benjamin,R., Friend,P., Bindon, C., Dyer,M., Qin,S., Bruggemann,M., Tighe,H.
Progress in Allergy 45, 16-30 (1988)
Monoclonal antibodies for immunosuppression.
Hayward A.R., Cobbold, S.P., Waldmann H., Cooke A., Simpson E..
J. Autoimmunity 1, 91-96 (1988)
Delay in onset of insulitis in NOD mice following a single injection of CD 4 and CD 8 antibodies.
Benjamin,R.J., Qin,S., Wise,M.P., Cobbold,S.P., Waldmann,H.
Eur. J. Immunol., 18, 1079-88 (1988)
Monoclonal antibodies for tolerance induction: a possible role for the CD4 (L3T4) and CD11a (LFA-1) molecules in self-non-self discrimination.
Cobbold,S., Hale,G., Waldmann,H.
Leucocyte Typing III: white cell differentiation antigens (ed McMichael,A.J. et al.) pub Oxford University Press, Oxford. pp 788-803 (1987)
Non-lineage, LFA-1 family, and leucocyte common antigens: new and previously defined clusters.
Muller,I., Cobbold,S.P., Waldmann,H., Kaufmann,S.H.E.
Infect. Immunol. 55, 2037-2041 (1987)
Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells.
Nash,A.A., Jayasuriya,A., Phelan,J., Cobbold,S.P., Waldmann,H., Prospero,T.
J. Gen. Virol. 68, 825-833 (1987)
Different roles for L3T4+ and Lyt-2+ T cell subsets in the control of an acute Herpes Simplex virus infection of the skin and nervous system.
Qin,S., Cobbold,S., Tighe,H., et al.
Eur. J. Immunol. 17, 1159-1165 (1987)
CD4 monoclonal antibody pairs for immunosuppression and tolerance induction.
Waldmann,H., Cobbold,S., Qin,S., Benjamin,R., Nash,A., Welsh,J., Tarnesby,G.
CIBA Found. Symp. 129,194-208 Autoimmunity and autoimmune disease. (1987)
Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes.
Hale,G., Cobbold,S.P., Waldmann,H., Easter,G., Matejtschuk,P., & Coombs, R.R.A.
J. Immunol. Meth. 103, 59-67 (1987)
Isolation of low-frequency class-switch variants from rat hybrid myelomas.
Waldmann,H., Hale,G., Cobbold,S.
Leucocyte Typing III: white cell differentiation antigens (ed McMichael,A.J. et al.) pub Oxford University Press, Oxford. pp 932-937 (1987)
The immunobiology of bone marrow transplantation.
Waldmann, H., Cobbold, S. & Hale, G.
Lancet 1, 44 (1987)
Leukaemic relapse after Campath-1 treated bone-marrow transplantation for leukaemia (letter).
Waldmann,H., Cobbold,S., Lefkovits,I.
Lymphocytes: a practical approach. (ed Klaus,G.) pub IRL Press, Oxford. 163-188 (1987)
Limiting Dilution Analysis.
Moskophidis,D., Cobbold,S.P., Waldmann,H., Lehmann-Grube,F.
J. Virol. 61, 1867-1874 (1987)
Mechanism of recovery from acute virus infection: Treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response.
Kantwerk,G., Cobbold,S., Waldmann,H., Kolb,H.
Clin. Exp. Immunol. 70, 585-592 (1987)
L3T4 and Lyt-2 T cells are both involved in the generation of low-dose streptozotocin induced diabetes in mice.
Leist,T.P., Cobbold,S.P., Waldmann,H., et-al.
J. Immunol. 138, 2278-2281 (1987)
Functional analysis of T lymphocyte subsets in antiviral host defense.
Lightman,S., Cobbold,S., Waldmann,H., et-al.
Immunology 62, 139-144 (1987)
Do L3T4+ T cells act as effector cells in protection against influenza virus infection.
Mol. Cell. Probes 1, 61-72 (1987)
Human leukocyte differentiation antigens: monoclonal antibibody computer databases as a tool for the future.
Giraldo,A., Cobbold,S., Waldmann,H., Potoczak,V., Kong,Y.M.
Fed. Proc. 46, 1375 (1987)
In situ analysis of thyroid T cell infiltrates in murine experimental autoimmune thyroiditis (EAT).
Cobbold,S., Martin,G., & Waldmann,H.
Transplantation 42, 239-247 (1986)
Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection: The depletion of T-cell subsets in vitro and in vivo.
Cobbold,S.P., & Waldmann,H.
Transplantation 41, 634-639 (1986)
Skin allograft rejection by L3/T4 and LyT-2 T cell subsets.
Waldmann,H., & Cobbold,S.
Bone Marrow Transplantation in Malignant Disease (ed Edwards,C. & Nethersall,A.) pub Wellcome pp 29-36 (1986)
Monoclonal antibodies and bone marrow transplantation.
Bruggemann,M., Free,J., Diamond,A., Howard,J., Cobbold,S., & Waldmann,H.
Proc. Natl. Acad. Sci. USA 83, 6075-6079 (1986)
Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes.
Cobbold, S.P., Clark, M.R., Benjamin, R.J., & Waldmann, H.
British Patent no 8608068 and International Patents applied for.(1986)
Monoclonal antibodies and their use.
Cobbold,S.P., Martin,G., Qin,S., & Waldmann,H.
Nature 323, 164-166 (1986)
Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance.
Muller,S., Cobbold,S., Waldmann,H., Kauffmann,S.H.E.
Immunobiology 173, 415 (1986)
Role of T lymphocytes in protection against Mycobacterium tuberculosis.
Benjamin,R.J., Cobbold,S.P., Clark,M.R., & Waldmann,H.
J. Exp. Med. 163, 1539-1552 (1986)
Tolerence to rat monoclonal antibodies: implications for serotherapy.
Cobbold,S.P., Martin,G., Lovat,P.E., Waldmann,H.
Adv. Exp. Med. Biol. 186, 789-795 (1985)
Immunosuppression with monoclonal antibodies- rules for effective serotherapy.
Cobbold,S.P., & Waldmann,H.
Nature 308, 460-462. (1984)
Therapeutic potential of monovalent monoclonal antibodies.
Clark,M.R., Cobbold,S.P., Waldmann,H., & Coombs.R.R.A.
J. Immunol. Meth. 66, 81-87 (1984)
Detection of monoclonal antibodies against cell surface antigens: the use of antiglobulins coupled to red blood cells.
Cobbold,S.P., Jayasuriya,A., Nash,A., Prospero,T.D., & Waldmann,H.
Nature 312, 548-551 (1984)
Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo.
Aqel,N.M., Clark,M., Cobbold,S.P., & Waldmann,H.
J. Immunol. Meth. 69, 207-214 (1984)
Immunological screening in the selection of monoclonal antibodies: the use of isotype-specific antiglobulins
Clark,M., Cobbold,S., Hale,G., & Waldmann,H.
Brit. J. Cancer 50, 562 (1984)
Monoclonal antibodies of therapeutic potential which interact with host effector systems.
Watt,S.M., Gilmore,D.J., Metcalf,D., Cobbold,S.P., Hoang,T.K., & Waldmann,H.
J. Cell. Physiol. 115, 37-45 (1983)
Segregation of mouse hemopoietic progenitor cells using the monoclonal antibody YBM 42.
Clark,M., Cobbold,S., Hale,G., & Waldmann,H.
Immunol. Today 4, 100-101 (1983)
Advantages of rat monoclonal antibodies.
Hoang,T., Gilmore,D., Metcalf,D., Cobbold,S., Watt,S., Clark,M., Furth,M., & Waldmann,H.
Blood 61, 580-588 (1983)
Separation of hemopoietic cells from adult mouse marrow by use of monoclonal antibodies.
Cobbold, S.P., & Waldmann, H.
British Patent no 8318575 and International Patents applied for.(1983)
Improvements in or relating to antibody preparations. Monovalent monoclonal antibodies.
PhD thesis, Cambridge (1983)
Monoclonal antibodies against differentiation antigens of the mouse haemopoetic system.
Cobbold,S.P., Thierfelder,S., & Waldmann,H.
Mol. Biol. Med. 1, 285-304 (1983)
Immunosuppression with monoclonal antibodies: A model to determine the rules for effective serotherapy.
Cobbold,S.P., & Waldmann,H.
J. Immunol. Meth. 44, 125-134 (1981)
A rapid solid-phase enzyme-linked binding assay for screening monoclonal antibodies to cell surface antigens.

Last updated 17th November 2015