Paul Fairchild's Publications

Publications listed with most recent first:
Lui KO, Boyd AS, Cobbold SP, Waldmann H, Fairchild PJ.
A Role for Regulatory T Cells in Acceptance of Embryonic Stem Cell-Derived Tissues Transplanted Across an MHC Barrier.
Stem Cells. 2010 Aug 24. [Epub ahead of print] PubMed PMID: 20737577.
Boyd AS, Fairchild PJ.
Approaches for immunological tolerance induction to stem cell-derived cell replacement therapies.
Expert Rev Clin Immunol. 2010 May;6(3):435-48. Review. PubMed PMID: 20441429.
Farquhar CA, Paterson AM, Cobbold SP, Garcia Rueda H, Fairchild PJ, Yates SF, Adams E, Saunders NJ, Waldmann H, Nolan KF.
Tolerogenicity is not an absolute property of a dendritic cell.
Eur J Immunol. 2010 Jun;40(6):1728-37. PubMed PMID: 20373289.
Tseng SY, Nishimoto KP, Silk KM, Majumdar AS, Dawes GN, Waldmann H, Fairchild PJ, Lebkowski JS, Reddy A.
Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells.
Regen Med. 2009 Jul;4(4):513-26. PubMed PMID: 19580370.
Cobbold SP, Adams E, Farquhar CA, Nolan KF, Howie D, Lui KO, Fairchild PJ, Mellor AL, Ron D, Waldmann H.
Infectious tolerance via the consumption of essential amino acids and mTOR signaling.
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12055-60. Epub 2009 Jun 30. PubMed PMID: 19567830; PubMed Central PMCID: PMC2704109.
Fairchild PJ.
Transplantation tolerance in an age of induced pluripotency.
Curr Opin Organ Transplant. 2009 Aug;14(4):321-5. Review. PubMed PMID: 19542888.
Silk KM, Fairchild PJ.
Harnessing dendritic cells for the induction of transplantation tolerance.
Curr Opin Organ Transplant. 2009 Aug;14(4):344-50. Review. PubMed PMID: 19417656.
Lui KO, Waldmann H, Fairchild PJ.
Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy.
Curr Stem Cell Res Ther. 2009 Jan;4(1):70-80. Review. PubMed PMID: 19149632.
Waldmann H, Adams E, Fairchild P, Cobbold S.
Regulation and Privilege in Transplantation Tolerance.
J Clin Immunol. 2008 Sep 6. [Epub ahead of print]
Robertson NJ, Brook FA, Gardner RL, Cobbold SP, Waldmann H, Fairchild PJ.
Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance.
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20920-5. Epub 2007 Dec 18.
Robertson NJ, Fairchild PJ, Waldmann H.
Ectopic transplantation of tissues under the kidney capsule.
Methods Mol Biol. 2007;380:347-53.
Fairchild PJ, Nolan KF, Waldmann H.
Genetic modification of dendritic cells through the directed differentiation of embryonic stem cells.
Methods Mol Biol. 2007;380:59-72.
Fairchild PJ, Robertson NJ, Minger SL, Waldmann H.
Embryonic stem cells: protecting pluripotency from alloreactivity.
Curr Opin Immunol. 2007 Oct;19(5):596-602. Epub 2007 Aug 20. Review.
Yates SF, Paterson AM, Nolan KF, Cobbold SP, Saunders NJ, Waldmann H, Fairchild PJ.
Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation.
J Immunol. 2007 Jul 15;179(2):967-76.
Fairchild PJ, Robertson NJ, Cartland S, Nolan KF, Waldmann H.
Cell replacement therapy and the evasion of destructive immunity.
Stem Cell Rev. 2005;1(2):159-67. Review.
Cobbold SP, Adams E, Graca L, Daley S, Yates S, Paterson A, Robertson NJ, Nolan KF, Fairchild PJ, Waldmann H.
Immune privilege induced by regulatory T cells in transplantation tolerance.
Immunol Rev. 2006 Oct;213:239-55. Review.
Waldmann H, Adams E, Fairchild P, Cobbold S.
Infectious tolerance and the long-term acceptance of transplanted tissue.
Immunol Rev. 2006 Aug;212:301-13. Review.
Graca L, Daley S, Fairchild PJ, Cobbold SP, Waldmann H.
Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning.
BMC Immunol. 2006 Apr 25;7:9.
Waldmann H, Chen TC, Graca L, Adams E, Daley S, Cobbold S, Fairchild PJ.
Regulatory T cells in transplantation.
Semin Immunol. 2006 Apr;18(2):111-9. Epub 2006 Feb 14. Review.
Waldmann H, Graca L, Adams E, Fairchild P, Cobbold S.
Regulatory T cells in transplantation tolerance.
Curr Top Microbiol Immunol. 2005;293:249-64. Review.
Fairchild PJ, Nolan KF, Cartland S, Waldmann H.
Embryonic stem cells: a novel source of dendritic cells for clinical applications.
Int Immunopharmacol. 2005 Jan;5(1):13-21.
Fairchild PJ, Cartland S, Nolan KF, Waldmann H.
Embryonic stem cells and the challenge of transplantation tolerance.
Trends Immunol. 2004 Sep;25(9):465-70. Review.
Graca L, Le Moine A, Lin CY, Fairchild PJ, Cobbold SP, Waldmann H.
Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells.
Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10122-6. Epub 2004 Jun 24.
Chen, T-C., Waldmann, H., Fairchild, PJ.
Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen, Dby.
J. Clin. Invest. 113: 1754-1762.
Abstract | Article | PDF
Chen, T-C., Cobbold, SP., Fairchild, PJ., Waldmann, H.
Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen.
J. Immunol. 172: 5900-5907.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Nolan KF, Strong V, Soler D, Fairchild PJ, Cobbold SP, Croxton R, Gonzalo JA, Rubio A, Wells M, Waldmann H.
IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals.
J Immunol. 172(4):2201-9.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Cobbold, SP., Nolan, K., Graca, L., Castejon, R., LeMoine, A., Frewin, M., Humm, S., Adams, E., Thompson, S., Zelenika, D., Paterson, A., Yates, S., Fairchild, PJ., Waldmann, H.
Regulatory T cells and Dendritic cells in Transplantation Tolerance: molecular markers and mechanisms.
Immunol. Reviews 196: 109-124.
Fairchild, PJ., Nolan, KF., Graca, L., Waldmann, H.
Stable lines of genetically modified dendritic cells from mouse embryonic stem cells.
Transplantation, 76: 606-608.
Fairchild, PJ., Nolan, KF., Waldmann, H.
Probing dendritic cell function by guiding the differentiation of embryonic stem cells.
Methods Enzymol. 365: 169-186.
Fairchild, PJ., Brook, RL., Gardner, L., Graca, L., Strong, V., Tone, Y., Tone, M., Nolan, KF., Waldmann, H.
Directed differentiation of dendritic cells from mouse embryonic stem cells: a novel tool for identifying targets for immunotherapy.
in Dodet, B., and Vicari, M. (Eds)
Pluripotent stem cells: therapeutic perspectives and ethical issues. pp 25-38.
John Libbey Eurotext, Paris (Pub)
Waldmann, H., Cobbold, SP., Fairchild, P. and Adams, E.
Therapeutic aspects of tolerance.
Current Opinions in Pharmacology 1: 392-397.
Tone M, Tone Y, Fairchild PJ, Wykes M, Waldmann H.
Regulation of CD40 function by its isoforms generated through alternative splicing.
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1751-6.
Fairchild PJ, Brook FA, Gardner RL, Graca L, Strong V, Tone Y, Tone M, Nolan KF, Waldmann H.
Directed differentiation of dendritic cells from mouse embryonic stem cells.
Curr Biol. 2000 Nov 30;10(23):1515-8.
Fairchild PJ, Waldmann H.
Dendritic cells and prospects for transplantation tolerance.
Curr Opin Immunol. 2000 Oct;12(5):528-35. Review.
Fairchild PJ, Waldmann H.
Extrathymic signals regulate the onset of T cell repertoire selection.
Eur J Immunol. 2000 Jul;30(7):1948-56.
Fairchild PJ.
Reversal of immunodominance among autoantigenic T-cell epitopes.
Autoimmunity. 1999;30(4):209-21. Review.
Fairchild, P.J., Tone, M., Strong, V. and Nolan, K.F. (2000)
Spanning innate and adaptive immunity: A role for interleukin-18.
Int. Rev. Immunol. In Press.
Fairchild, P.J. (1999)
Reversal of immunodominance among autoantigenic T-cell epitopes.
Autoimmunity 30(4):209-21.
Babik, J.M., Adams, E., Tone, Y., Fairchild, P.J., Tone, M. and Waldmann H. (1999)
Expression of murine interleukin-12 is regulated by translational control of the p35 subunit.
J. Immunol. 162: 4069-4078.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Fairchild, P.J. (1998)
Presentation of antigenic peptides by products of the Major Histocompatibility Complex.
J Peptide Science 4(3):182-194.
Tone, M., Thompson, S.A.J., Tone, Y., Fairchild, P.J. and Waldmann, H. (1997)
Regulation of interleukin-18 (interferon-g-inducing factor) gene expression.
J. Immunol. 159:6156-6163.
Fairchild, P.J. (1997)
Altered peptide ligands: prospects for immune intervention in autoimmune disease.
Eur. J. Immunogenetics 24: 155-167.
Fairchild, P.J. and D.C. Wraith (1996)
Lowering the tone: mechanisms of immunodominance among epitopes with low affinity for MHC.
Immunol Today 17(2):80-85
Brocke, S, K. Gijbels, M. Allegretta, I. Ferber, C. Piercy, T. Blankenstein, R. Martin, U. Utz, N. Karin, D. Mitchell, T. Veromaa, A. Waisman, A. Gaur, P. Conlon, N. Ling, P.J. Fairchild, D.C. Wraith, A. O'Garra, C.G. Fathman and L. Steinman (1996)
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein.
Nature 379:343-346.
Fairchild, P.J., H. Franks and D.C. Wraith (1996)
The nature of cryptic epitopes within the self-antigen myelin basic protein.
Int Immunol 9: 1035-43.
Fairchild, P.J. and J.M. Austyn (1995)
Developmental changes predispose the fetal thymus to positive selection of CD4+CD8- T cells.
Immunol 85:292-298
Fairchild, P.J., E.S. Cohen and D.C. Wraith (1995)
Processing of myelin basic protein by macrophages generates an epitope with apparent low affinity for I-As.
Biochem Soc Trans 23:686-691
Liu, G.Y., P.J. Fairchild, R.M. Smith, J.R. Prowle, D. Kioussis and D.C. Wraith (1995)
Low avidity recognition of self-antigen by T cells permits escape from central tolerance.
Immunity 3:407-415 (Joint first authorship)
Fairchild, P.J. and H.C. Macgregor (1994)
Lampbrush chromosomes: asymmetric loops.
Cur Biol 4:919.
Fairchild, P.J., C.J. Thorpe, P.J. Travers and D.C. Wraith (1994)
Modulation of the immune response with T-cell epitopes: the ultimate goal for specific immunotherapy of autoimmune disease.
Immunol 81:487-496
Fairchild, P.J., R. Wildgoose, E. Atherton, S. Webb, and D.C. Wraith (1993)
An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction.
Int Immunol 5:1151-1158
Fairchild, P.J. and J.M. Austyn (1993)
Chimeric thymus rudiments: a strategy for the study of tolerance induction in vitro.
ImmunoMethods 2:145-158
Smith, R.M. and P.J. Fairchild (1992)
Monoclonal antibodies: harnessing the potential.
Sci Progress 76:323-343
Wraith, D.C., B. Bruun and P.J., Fairchild (1992)
Cross-reactive antigen recognition by an encephalitogenic T cell receptor. Implications for T cell biology and autoimmunity.
J Immunol 149:3765-3770
Fairchild, P.J. and D.C. Wraith (1992)
Peptide-MHC interaction in autoimmunity.
Cur Opin Immunol 4:748-753
Fairchild, P.J. and J.M. Austyn (1990)
Thymic dendritic cells: phenotype and function.
Int Rev Immunol 6:187-196

Last updated 2nd September 2010