Professor Waldmann's Publications

Listed with most recent first:

Waldmann H.
Mechanisms of immunological tolerance.
Clin Biochem. 2015 May 30. doi: 10.1016/j.clinbiochem.2015.05.019.
Meister M, Papatriantafyllou M, Nordström V, Kumar V, Ludwig J, Lui KO, Boyd AS, Popovic ZV, Fleming TH, Moldenhauer G, Nawroth PP, Gröne HJ, Waldmann H, Oelert T, Arnold B.
Dickkopf-3, a tissue-derived modulator of local T-cell responses.
Front Immunol. 2015 Feb 24;6:78. doi: 10.3389/fimmu.2015.00078.
Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H.
Tolerance induction to human stem cell transplants with extension to their differentiated progeny.
Nat Commun. 2014 Dec 1;5:5629. doi: 10.1038/ncomms6629.
Han SO, Li S, Brooks ED, Masat E, Leborgne C, Banugaria S, Bird A, Mingozzi F, Waldmann H, Koeberl D.
Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade.
Hum Gene Ther. 2015 Jan;26(1):26-35. doi:10.1089/hum.2014.115.
Howie D, Waldmann H, Cobbold S.
Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment.
Front Immunol. 2014 Aug 28;5:409. doi:10.3389/fimmu.2014.00409.
Waldmann H,.
Drug minimization in transplantation: an opinion.
Curr Opin Organ Transplant. 2014 Aug;19(4):331-3.
Piotti G, Ma J, Adams E, Cobbold S, Waldmann H,.
Guiding postablative lymphocyte reconstitution as a route toward transplantation tolerance.
Am J Transplant. 2014 Jul;14(7):1678-89.
Waldmann H,, Hilbrands R, Howie D, Cobbold S.
Harnessing FOXP3+ regulatory T cells for transplantation tolerance.
J Clin Invest. 2014 Apr 1;124(4):1439-45.
Tone Y, Kidani Y, Ogawa C, Yamamoto K, Tsuda M, Peter C, Waldmann H,, Tone M.
Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.
J Immunol. 2014 Apr 15;192(8):3915-24.
Whibley N, Maccallum DM, Vickers MA, Zafreen S, Waldmann H,, Hori S, Gaffen SL, Gow NA, Barker RN, Hall AM.
Expansion of Foxp3(+) T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge.
Eur J Immunol. 2014 Apr;44(4):1069-83.
Ogawa C, Tone Y, Tsuda M, Peter C, Waldmann H,, Tone M.
TGF-β-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2.
J Immunol. 2014 Jan 1;192(1):475-83.
Worthington JJ, Klementowicz JE, Rahman S, Czajkowska BI, Smedley C, Waldmann H, Sparwasser T, Grencis RK, Travis MA.
Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.
PLoS Pathog. 2013;9(10):e1003675.
Howie D, Garcia Rueda H, Brown MH, Waldmann H,.
Secreted and transmembrane 1A is a novel co-stimulatory ligand.
PLoS One. 2013 Sep 10;8(9):e73610.
Waldmann H,.
Human monoclonal antibodies: the residual challenge of antibody immunogenicity.
Methods Mol Biol. 2014;1060:1-8.
Hilbrands R, Howie D, Cobbold S, Waldmann H,.
Regulatory T cells and transplantation tolerance.
Immunotherapy. 2013 Jul;5(7):717-31.
Cobbold SP, Waldmann H,.
Regulatory cells and transplantation tolerance.
Cold Spring Harb Perspect Med. 2013 Jun 1;3(6). pii: a015545.
Sakaguchi S, Vignali DA, Rudensky AY, Niec RE, Waldmann H,.
The plasticity and stability of regulatory T cells.
Nat Rev Immunol. 2013 Jun;13(6):461-7.
Regateiro FS, Cobbold SP, Waldmann H.
CD73 and adenosine generation in the creation of regulatory microenvironments.
Clin Exp Immunol. 2013 Jan;171(1):1-7.
Regateiro FS, Chen Y, Kendal AR, Hilbrands R, Adams E, Cobbold SP, Ma J, Andersen KG, Betz AG, Zhang M, Madhiwalla S, Roberts B, Waldmann H, Nolan KF, Howie D.
Foxp3 expression is required for the induction of therapeutic tissue tolerance.
J Immunol. 2012 Oct 15;189(8):3947-56.
Chen Y, Adams E, Regateiro FS, Vaux DJ, Betz AG, Andersen KG, Waldmann H, Howie D.
Activation rather than Foxp3 expression determines that TGF-ß-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering.
Eur J Immunol. 42(6):1436-48. doi: 10.1002/eji.201142207.
Agorogiannis EI, Regateiro FS, Howie D, Waldmann H, Cobbold SP.
Th17 cells induce a distinct graft rejection response that does not require IL-17A.
Am J Transplant. 12(4):835-45.
Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S.
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.
Immunity. 36(2):262-75.
Alkemade GM, Hilbrands R, Vandemeulebroucke E, Pipeleers D, Waldmann H, Mathieu C, Keymeulen B, Roep BO.
Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients.
Diabetes Metab Res Rev. 27(8):925-7.
Kendal AR, Chen Y, Regateiro FS, Ma J, Adams E, Cobbold SP, Hori S, Waldmann H.
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.
J Exp Med. Aug 29. doi: 10.1084/jem.20110767
Regateiro FS, Howie D, Cobbold SP, Waldmann H.
TGF-ß in transplantation tolerance.
Curr Opin Immunol. Aug 10. 21839624.
Regateiro FS, Howie D, Nolan KF, Agorogiannis EI, Greaves DR, Cobbold SP, Waldmann H.
Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-ß.
Eur J Immunol. 2011 Jul 19. doi: 10.1002/eji.201141512.
McIntosh JH, Cochrane M, Cobbold S, Waldmann H, Nathwani SA, Davidoff AM, Nathwani AC.
Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine.
Gene Ther. Jun 30. doi: 10.1038/gt.2011.64.
Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, Rudensky AY, Ichinose H, Metzger D, Chambon P, Yoshimura A.
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.
Nat Commun. 2:269.
Cobbold SP, Adams A and Waldmann H.
Biomarkers of transplantation tolerance: more hopeful than helpful?
Front. Immun. 2:9. doi: 10.3389/fimmu.2011.00009
Kuhn C, You S, Valette F, Hale G, van Endert P, Bach JF, Waldmann H, Chatenoud L.
Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance.
Sci Transl Med. 2011 Feb 2;3(68):68ra10. PubMed PMID: 21289272.
Honda T, Otsuka A, Tanizaki H, Minegaki Y, Nagao K, Waldmann H, Tomura M, Hori S, Miyachi Y, Kabashima K.
Enhanced murine contact hypersensitivity by depletion of endogenous regulatory T cells in the sensitization phase.
J Dermatol Sci. 2011 Feb;61(2):144-7. Epub 2010 Nov 11. PubMed PMID: 21129920.
Lui KO, Fairchild PJ, Waldmann H.
Prospects for ensuring acceptance of ES cell-derived tissues. 2010 Sep 30.
StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
Available from here. PubMed PMID: 20963944.
Greene MI, Waldmann H.
Regulation of the immune response.
Curr Opin Immunol. 2010 Oct;22(5):549-51. Epub 2010 Oct 16. PubMed PMID: 20956073.
Peter C, Waldmann H, Cobbold SP.
mTOR signalling and metabolic regulation of T cell differentiation.
Curr Opin Immunol. 2010 Sep 10. [Epub ahead of print] PubMed PMID: 20833524.
Kendal AR, Waldmann H.
Infectious tolerance: therapeutic potential.
Curr Opin Immunol. 2010 Sep 7. [Epub ahead of print] PMID: 20829013.
Lui KO, Boyd AS, Cobbold SP, Waldmann H, Fairchild PJ.
A Role for Regulatory T Cells in Acceptance of Embryonic Stem Cell-Derived Tissues Transplanted Across an MHC Barrier.
Stem Cells. 2010 Aug 24. [Epub ahead of print] PubMed PMID: 20737577.
Waldmann H.
Tolerance: an overview and perspectives.
Nat Rev Nephrol. 2010 Aug 17. [Epub ahead of print] PubMed PMID: 20717099.
Cobbold, SP., Adams, E., Nolan, KF., Regateiro, FS., and Waldmann, H.
Connecting the mechanisms of T cell regulation: dendritic cells as the missing link.
Immunological Reviews 236:203-218.
Somerfield J, Hill-Cawthorne GA, Lin A, Zandi MS, McCarthy C, Jones JL, Willcox M, Shaw D, Thompson SA, Compston AS, Hale G, Waldmann H, Coles AJ.
A novel strategy to reduce the immunogenicity of biological therapies.
J Immunol. 1;185(1):763-8. Epub 2010 Jun 2. PubMed PMID: 20519651.
Condamine T, Le Texier L, Howie D, Lavault A, Hill M, Halary F, Cobbold S, Waldmann H, Cuturi MC, Chiffoleau E.
Tmem176B and Tmem176A are associated with the immature state of dendritic cells.
J Leukoc Biol. 2010 May 28. [Epub ahead of print] PubMed PMID: 20501748.
Farquhar CA, Paterson AM, Cobbold SP, Garcia Rueda H, Fairchild PJ, Yates SF, Adams E, Saunders NJ, Waldmann H, Nolan KF.
Tolerogenicity is not an absolute property of a dendritic cell.
Eur J Immunol. 2010 Jun;40(6):1728-37. PubMed PMID: 20373289.
Ponte JF, Ponath P, Gulati R, Slavonic M, Paglia M, O'Shea A, Tone M, Waldmann H, Vaickus L, Rosenzweig M.
Enhancement of humoral and cellular immunity with an anti-glucocorticoid-induced tumour necrosis factor receptor monoclonal antibody.
Immunology. 2010 Jun;130(2):231-42. Epub 2010 Feb 26. PubMed PMID: 20201988; PubMed Central PMCID: PMC2878467.
Tomura M, Honda T, Tanizaki H, Otsuka A, Egawa G, Tokura Y, Waldmann H, Hori S, Cyster JG, Watanabe T, Miyachi Y, Kanagawa O, Kabashima K.
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice.
J Clin Invest. 2010 Feb 22. pii: 40926. doi:10.1172/JCI40926. [Epub ahead of print]
Hale G, Rebello P, Al-Bakir I, Bolam E, Wiczling P, Jusko WJ, Vandemeulebroucke E, Keymeulen B, Mathieu C, Ziegler AG, Chatenoud L, Waldmann H.
Pharmacokinetics and Antibody Responses to the CD3 Antibody Otelixizumab Used in the Treatment of Type 1 Diabetes.
J Clin Pharmacol. 2010 Feb 10. [Epub ahead of print]
Keymeulen B, Walter M, Mathieu C, Kaufman L, Gorus F, Hilbrands R, Vandemeulebroucke E, Van de Velde U, Crenier L, De Block C, Candon S, Waldmann H, Ziegler AG, Chatenoud L, Pipeleers D.
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.
Diabetologia. 53(4):614-23. Epub 2010 Jan 14. PubMed PMID: 20225393.
Tong H, Miyazaki Y, Yamazaki M, Hara H, Waldmann H, Hori S, Yoshida H.
Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice.
Immunol Lett. 2010 Feb 16;128(2):108-15. Epub 2010 Jan 12.
Mehta DS, Christmas RA, Waldmann H, Rosenzweig M.
Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice.
Immunology. 2010 Jan 6. [Epub ahead of print]
Keymeulen B, Candon S, Fafi-Kremer S, Ziegler A, Leruez-Ville M, Mathieu C, Vandemeulebroucke E, Walter M, Crenier L, Thervet E, Legendre C, Pierard D, Hale G, Waldmann H, Bach JF, Seigneurin JM, Pipeleers D, Chatenoud L.
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients.
Blood. 2010 Feb 11;115(6):1145-55. Epub 2009 Dec 9.
You S, Poulton L, Cobbold S, Liu CP, Rosenzweig M, Ringler D, Lee WH, Segovia B, Bach JF, Waldmann H, Chatenoud L.
Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.
PLoS One. 2009 Nov 20;4(11):e7848.
Howie D, Nolan KF, Daley S, Butterfield E, Adams E, Garcia-Rueda H, Thompson C, Saunders NJ, Cobbold SP, Tone Y, Tone M, Waldmann H.
MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation.
J Immunol. 2009 Oct 1;183(7):4197-204. Epub 2009 Sep 14.
Poulton LD, Nolan KF, Anastasaki C, Waldmann H, Patton EE.
A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development.
Int J Dev Biol. 2009 Jul 1. [Epub ahead of print] PubMed PMID:19598108.
Tseng SY, Nishimoto KP, Silk KM, Majumdar AS, Dawes GN, Waldmann H, Fairchild PJ, Lebkowski JS, Reddy A.
Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells.
Regen Med. 2009 Jul;4(4):513-26. PubMed PMID: 19580370.
Cobbold, SP., Adams, E., Farquhar, CA., Nolan, KF., Howie, D., Lui, KO., Fairchild, PJ., Mellow, AL., Ron, D., Waldmann, H.
Infectious tolerance via the consumption of essential amino acids and mTOR signaling.
Proc Natl Acad Sci U S A. Epub 2009 June 30. doi:10.1073/pnas.0903919106.
Link to full version of the paper (Open Access).
Waldmann H, Cobbold S.
Regulatory T cells: context matters
Immunity 30, May22; 2009: 613-615.
Clatworthy MR, Friend PJ, Calne RY, Rebello PR, Hale G, Waldmann H, Watson CJ.
Alemtuzumab (CAMPATH-1H) for the treatment of acute rejection in kidney transplant recipients: long-term follow-up.
Transplantation. 2009 Apr15;87(7):1092-5.
Komatsu N, Mariotti-Ferrandiz ME, Wang Y, Malissen B, Waldmann H, Hori S.
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity.
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1903-8. Epub 2009 Jan 27.
Lui KO, Waldmann H, Fairchild PJ.
Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy.
Curr Stem Cell Res Ther. 2009 Jan;4(1):70-80.
CAMMS223 Trial Investigators, Coles AJ, Compston DA, Selmaj KW, Lake SL, Moran S, Margolin DH, Norris K, Tandon PK.
Alemtuzumab vs. Interferon beta-1a in early multiple sclerosis.
N Engl J Med. 2008 Oct 23;359(17):1786-801.
Li Z, Benghiat FS, Charbonnier LM, Kubjak C, Rivas MN, Cobbold SP, Waldmann H, De Wilde V, Petein M, Schuind F, Goldman M, Le Moine A.
CD8+ T-Cell Depletion and Rapamycin Synergize with Combined Coreceptor/Stimulation Blockade to Induce Robust Limb Allograft Tolerance in Mice.
Am J Transplant. 2008 Oct 6. [Epub ahead of print]
Daley SR, Cobbold SP, Waldmann H.
Fc-disabled anti-mouse CD40L antibodies retain efficacy in promoting transplantation tolerance.
Am J Transplant. 2008 Nov;8(11):2265-71. Epub 2008 Sep 8.
Waldmann H, Adams E, Fairchild P, Cobbold S.
Regulation and Privilege in Transplantation Tolerance.
J Clin Immunol. 2008 Sep 6. [Epub ahead of print]
Waldmann H.
Tolerance can be infectious.
Nat Immunol. 2008 Sep;9(9):1001-3.
Waldmann H, Adams E, Cobbold S.
Reprogramming the immune system: co-receptor blockade as a paradigm for harnessing tolerance mechanisms.
Immunol Rev. 2008 Jun;223:361-70.
Morgan AW, Hale G, Rebello PR, Richards SJ, Gooi HC, Waldmann H, Emery P, Isaacs JD.
A pilot study of combination anti-cytokine and anti-lymphocyte biological therapy in rheumatoid arthritis.
QJM. 2008 Feb 19; [Epub ahead of print]
Lorenzi AR, Clarke AM, Wooldridge T, Waldmann H, Hale G, Symmons D, Hazleman BL, Isaacs JD.
Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: twelve-year outcomes.
Arthritis Rheum. 2008 Feb;58(2):370-5.
Zhou Z, Tone Y, Song X, Furuuchi K, Lear JD, Waldmann H, Tone M, Greene MI, Murali R.
Structural basis for ligand-mediated mouse GITR activation.
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):641-5. Epub 2008 Jan 4.
Waldmann H.
Special regulatory T cell review: The suppression problem!
Immunology. 2008 Jan;123(1):11-2.
Robertson NJ, Brook FA, Gardner RL, Cobbold SP, Waldmann H, Fairchild PJ.
Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance.
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20920-5. Epub 2007 Dec 18.
Robertson NJ, Fairchild PJ, Waldmann H.
Ectopic transplantation of tissues under the kidney capsule.
Methods Mol Biol. 2007;380:347-53.
Nolan KF, Cobbold SP, Waldmann H.
SAGE analysis of cell types involved in tolerance induction.
Methods Mol Biol. 2007;380:225-51.
Fairchild PJ, Nolan KF, Waldmann H.
Genetic modification of dendritic cells through the directed differentiation of embryonic stem cells.
Methods Mol Biol. 2007;380:59-72.
Daley SR, Ma J, Adams E, Cobbold SP, Waldmann H.
A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts.
J Immunol. 2007 Sep 15;179(6):3648-54.
Fairchild PJ, Robertson NJ, Minger SL, Waldmann H.
Embryonic stem cells: protecting pluripotency from alloreactivity.
Curr Opin Immunol. 2007 Oct;19(5):596-602. Epub 2007 Aug 20. Review.
Fairchild PJ, Robertson NJ, Cartland S, Nolan KF, Waldmann H.
Cell replacement therapy and the evasion of destructive immunity.
Stem Cell Rev. 2005;1(2):159-67. Review.
Yates SF, Paterson AM, Nolan KF, Cobbold SP, Saunders NJ, Waldmann H, Fairchild PJ.
Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation.
J Immunol. 179(2):967-76.
Tuyaerts S, Van Meirvenne S, Bonehill A, Heirman C, Corthals J, Waldmann H, Breckpot K, Thielemans K, Aerts JL.
Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.
J Leukoc Biol. 82(1):93-105.
Cobbold SP, Adams E, Graca L, Daley S, Yates S, Paterson A, Robertson NJ, Nolan KF, Fairchild PJ, Waldmann H.
Immune privilege induced by regulatory T cells in transplantation tolerance.
Immunol Rev. 213:239-55.
Waldmann H.
Immunology: protection and privilege.
Nature. 442(7106):987-8.
Waldmann H, Adams E, Fairchild P, Cobbold S.
Infectious tolerance and the long-term acceptance of transplanted tissue.
Immunol Rev. 212:301-13.
Glatting G, Muller M, Koop B, Hohl K, Friesen C, Neumaier B, Berrie E, Bird P, Hale G, Blumstein NM, Waldmann H, Bunjes D, Reske SN.
Anti-CD45 monoclonal antibody YAML568: A promising radioimmunoconjugate for targeted therapy of acute leukemia.
J Nucl Med. 47(8):1335-41.
Graca L, Waldmann H.
Reprogramming the immune system using antibodies.
Methods Mol Biol. 333:247-68.
van de Linde P, Tysma OM, Medema JP, Hale G, Waldmann H, Roelen DL, Roep BO.
Mechanisms of antibody immunotherapy on clonal islet reactive T cells.
Hum Immunol. 67(4-5):264-73.
Graca L, Daley S, Fairchild PJ, Cobbold SP, Waldmann H.
Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning.
BMC Immunol. Apr 25;7:9.
Neujahr DC, Chen C, Huang X, Markmann JF, Cobbold S, Waldmann H, Sayegh MH, Hancock WW, Turka LA.
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it.
J Immunol. 176(8):4632-9.
Waldmann H, Chen TC, Graca L, Adams E, Daley S, Cobbold S, Fairchild PJ.
Regulatory T cells in transplantation.
Semin Immunol. 18(2):111-9.
Paterson AM, Yates SF, Nolan KF, Waldmann H.
The new immunosuppression: intervention at the dendritic cell-T-cell interface.
Curr Drug Targets Immune Endocr Metabol Disord. 5(4):397-411. Review.
Hisaeda H, Hamano S, Mitoma-Obata C, Tetsutani K, Imai T, Waldmann H, Himeno K, Yasutomo K.
Resistance of regulatory T cells to glucocorticoid-viduced TNFR family-related protein (GITR) during Plasmodium yoelii infection.
Eur J Immunol. 35(12):3516-24.
Cox AL, Thompson SA, Jones JL, Robertson VH, Hale G, Waldmann H, Compston DA, Coles AJ.
Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis.
Eur J Immunol.35(11):3332-42.
Stebbings R, Berry N, Waldmann H, Bird P, Hale G, Stott J, North D, Hull R, Hall J, Lines J, Brown S, D'Arcy N, Davis L, Elsley W, Edwards C, Ferguson D, Allen J, Almond N.
CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus.
J Virol. 79(19):12264-72.
Waldmann H, Hale G.
CAMPATH: from concept to clinic.
Philos Trans R Soc Lond B Biol Sci. 360(1461):1707-11.
Suvas S, Kim B, Sarangi PP, Tone M, Waldmann H, Rouse BT.
In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology.
J Virol. 2005 Sep;79(18):11935-42.
Novitzky N, Thomas V, Hale G, Waldmann H.
Myeloablative conditioning is well tolerated by older patients receiving T-cell-depleted grafts.
Bone Marrow Transplant. Aug 22; [Epub ahead of print]
Coles AJ, Cox A, Le Page E, Jones J, Trip SA, Deans J, Seaman S, Miller DH, Hale G, Waldmann H, Compston DA.
The window of therapeutic opportunity in multiple sclerosis Evidence from monoclonal antibody therapy.
J Neurol. 253:98-108.
Waldmann H, Graca L, Adams E, Fairchild P, Cobbold S.
Regulatory T cells in transplantation tolerance.
Curr Top Microbiol Immunol. 293:249-64.
Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S, Schandene L, Crenier L, De Block C, Seigneurin JM, De Pauw P, Pierard D, Weets I, Rebello P, Bird P, Berrie E, Frewin M, Waldmann H, Bach JF, Pipeleers D, Chatenoud L.
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
N Engl J Med. 352(25):2598-608.
Waldmann H.
Contact between good friends: what limiting dilution analysis taught us.
Scand J Immunol. 62 Suppl 1:30-2.
Peggs KS, Hunter A, Chopra R, Parker A, Mahendra P, Milligan D, Craddock C, Pettengell R, Dogan A, Thomson KJ, Morris EC, Hale G, Waldmann H, Goldstone AH, Linch DC, Mackinnon S.
Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation.
Lancet. 365(9475):1934-41.
Watson CJ, Bradley JA, Friend PJ, Firth J, Taylor CJ, Bradley JR, Smith KG, Thiru S, Jamieson NV, Hale G, Waldmann H, Calne R.
Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation--efficacy and safety at five years.
Am J Transplant. 5(6):1347-53.
You S, Belghith M, Cobbold S, Alyanakian MA, Gouarin C, Barriot S, Garcia C, Waldmann H, Bach JF, Chatenoud L.
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.
Diabetes. 54(5):1415-22.
Benghiat FS, Graca L, Braun MY, Detienne S, Moore F, Buonocore S, Flamand V, Waldmann H, Goldman M, Le Moine A.
Critical Influence of Natural Regulatory CD25+ T Cells on the Fate of Allografts in the Absence of Immunosuppression.
Transplantation. 79(6):648-654.
Waldmann H.
Thomas' hematopoietic cell transplantation.
Bone Marrow Transplant. 35(6):633.
Graca L, Chen TC, Moine AL, Cobbold SP, Howie D, Waldmann H.
Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells.
Trends Immunol. 26(3): 130-5.
Yee CS, Yao Y, Xu Q, McCarthy B, Sun-Lin D, Tone M, Waldmann H, Chang CH.
Enhanced Production of IL-10 by Dendritic Cells Deficient in CIITA.
J Immunol. 174(3):1222-9.
Fairchild PJ, Nolan KF, Cartland S, Waldmann H.
Embryonic stem cells: a novel source of dendritic cells for clinical applications.
Int Immunopharmacol. 5(1):13-21.
Gupta V, Ball SE, Yi QL, Sage D, McCann SR, Lawler M, Ortin M, Freires M, Hale G, Waldmann H, Gordon-Smith EC, Marsh JC.
Favorable effect on acute and chronic graft-versus-host disease with cyclophosphamide and in vivo anti-CD52 monoclonal antibodies for marrow transplantation from HLA-identical sibling donors for acquired aplastic anemia.
Biol Blood Marrow Transplant 10(12): 867-76.
Novitzky N, Thomas V, Stubbings H, Hale G, Waldmann H.
Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia.
Cytotherapy 6(5): 450-6.
Winsor-Hines D, Merrill C, O'Mahony M, Rao PE, Cobbold SP, Waldmann H, Ringler DJ, Ponath PD
Induction of Immunological Tolerance/Hyporesponsiveness in Baboons with a Nondepleting CD4 Antibody
J. Immunol. 173: 4715-4723. Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Mellor AL, Chandler P, Baban B, Hansen AM, Marshall B, Pihkala J, Waldmann H, Cobbold S, Adams E, Munn DH.
Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase.
Int Immunol. Sep 6 [Epub ahead of print]
Fairchild PJ, Cartland S, Nolan KF, Waldmann H.
Embryonic stem cells and the challenge of transplantation tolerance.
Trends Immunol. 25(9):465-70.
Chakrabarti S, Hale G, Waldmann H.
Alemtuzumab (Campath-1H) in allogeneic stem cell transplantation: where do we go from here?
Transplant Proc.36(5):1225-7.
Waldmann, H., Cobbold, S.
Viewpoint: Exploiting tolerance processes in transplantation
Science 305: 209-212.
Abstract Full Text
Graca L, Le Moine A, Lin CY, Fairchild PJ, Cobbold SP, Waldmann H.
Donor-specific transplantation tolerance: The paradoxical behavior of CD4+CD25+ T cells.
Proc Natl Acad Sci U S A. 101(27):10122-6.
Novitzky N, Thomas V, Hale G, Waldmann H.
Campath-1 Abs 'in the bag' for hematological malignancies: the Cape Town experience.
Cytotherapy. 6(2):172-81.
Chen, T-C., Waldmann, H., Fairchild, PJ.
Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen, Dby.
J. Clin. Invest. 113: 1734-1742.
Abstract | Article | PDF
Murphy CC, Greiner K, Plskova J, Duncan L, Frost A, Isaacs JD, Rebello P, Waldmann H, Hale G, Forrester JV, Dick AD.
Neutralizing tumor necrosis factor activity leads to remission in patients with refractory noninfectious posterior uveitis.
Arch Ophthalmol. Jun;122(6):845-51.
Hale G, Rebello P, Brettman L, Fegan C, Kennedy B, Kimby E, Leach M, Lundin J, Mellstedt H, Moreton P, Rawstron A, Waldmann H, Osterborg A, Hillmen P.
Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration.
Blood. 2004 Apr 15 [Epub ahead of print]
Cobbold, SP., Castejon, R., Adams, E., Zelenika, D., Graca, L., Humm, S., Waldmann, H.
Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.
J. Immunol. 172: 6003-6010.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Chen, T-C., Cobbold, SP., Fairchild, PJ., Waldmann, H.
Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen.
J. Immunol. 172: 5900-5907.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Waldmann, H., Graca, L., Cobbold, SP., Adams, E., Tone, M., Tone, Y.
Regulatory T cells and organ transplantation
Seminars in Immunology 16(2): 119-126.
Avivi I, Chakrabarti S, Milligan DW, Waldmann H, Hale G, Osman H, Ward KN, Fegan CD, Yong K, Goldstone AH, Linch DC, Mackinnon S.
Incidence and outcome of adenovirus disease in transplant recipients after reduced-intensity conditioning with alemtuzumab.
Biol Blood Marrow Transplant. 10(3):186-94.
Nolan KF, Strong V, Soler D, Fairchild PJ, Cobbold SP, Croxton R, Gonzalo JA, Rubio A, Wells M, Waldmann H.
IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals.
J Immunol. 172(4):2201-9.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Lockwood, C. M., G. Hale, et al.
Remission induction in Behcet's disease following lymphocyte depletion by the anti-CD52 antibody CAMPATH 1-H.
Rheumatology (Oxford) 42(12): 1539-44.
Tone, M., Tone, Y., Adams, E., Yates, SF., Frewin, M., Cobbold, SP., Waldmann, H.
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells
Proc. Natl. Acad. Sci. USA. 100 (25): 15059-15064.
published online before print.
Fairchild, PJ., Nolan, KF., Waldmann, H.
Probing dendritic cell function by guiding the differentiation of embryonic stem cells.
Methods Enzymol. 365: 169-186.
Graca, L., LeMoine, A., Cobbold, SP., Waldmann, H.
Antibody-induced transplantation tolerance: the role of dominant regulation.
Immunol. Research, 28(3): 181-191.
Cobbold, SP., Nolan, K., Graca, L., Castejon, R., LeMoine, A., Frewin, M., Humm, S., Adams, E., Thompson, S., Zelenika, D., Paterson, A., Yates, S., Fairchild, PJ., Waldmann, H.
Regulatory T cells and Dendritic cells in Transplantation Tolerance: molecular markers and mechanisms.
Immunol. Reviews 196: 109-124.
Chakrabarti S, Milligan DW, Pillay D, Mackinnon S, Holder K, Kaur N, McDonald D, Fegan CD, Waldmann H, Hale G, Rickinson A, Steven N.
Reconstitution of the Epstein-Barr virus-specific cytotoxic T-lymphocyte response following T-cell-depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation.
Blood 102(3): 839-42.
Waldmann, H.
The new immunosuppression: just kill the T cell
Nature Medicine 9: 1259-1260.
D'Sa, S., Peggs, K., Pizzey, A., Verfuerth, S., Thuraisundaram, D., Watts, M., Hale, G., Waldmann, H., Goldstone, A., McKinnon, S., Yong, K.
T- and B-cell immune reconstitution and clinical outcome in patients with multiple myeloma receiving T-cell-depleted, reduced-intensity allogeneic stem cell transplantation with alemtuzumab-containing conditioning regimen followed by escalated donor lymphocyte infusions.
Br. J. Haematol. 123(2): 309-322.
Waldmann, H.
Transplantation. Regulating the rejection process: the search for new targets to minimise immunosuppressive therapy.
Curr. Opin. Immunol. 15(5): 477-478.
Graca, L., LeMoine, A., Cobbold SP., Waldmann, H.
Dominant transplantation tolerance.
Curr. Opin. Immunol., 15(5): 499-506.
Waldmann, H.
The new immunosuppression
Current Opinion in Chemical Biology 7: 476-4809.
Cobbold, SP., Adams, E., Graca, L., Waldmann, H.
Serial analysis of gene expression provides new insights into regulatory T cells.
Seminars in Immunology 15(4): 209-214.
Peggs, KS., MacKinnon, S., Williams, CD., D'Sa, S., Thuraisundaram, D., Kyriakou, C., Morris, EC., Hale, G., Waldmann, H. Linch, DC., Goldstone, AH., Yong, K.
Reduced intensity transplantation with in vivo T-cell depletion and adjuvant dose-escalating donor lympjhocyte infusions for chemotherapy-sensitive myeloma: Limited efficacy of graft-versus-tumor activity.
Biol. Blood Marrow Transplant. 9(4): 257-265.
Fairchild, PJ., Nolan, KF., Cartland, S., Graca, L., Waldmann, H.
Stable lines of genetically modified dendritic cells from mouse embryonic stem cells.
Transplantation 76(3): 606-608.
Chakrabarti S, MacDonald D, Hale G, Holder K, Turner V, Czarnecka H, Thompson J, Fegan C, Waldmann H, Milligan DW.
T-cell depletion with Campath-1H 'in the bag' for matched related allogeneic peripheral blood stem cell transplantation is associated with reduced graft-versus-host disease, rapid immune constitution and improved survival.
Br J Haematol. 121(1):109-18.
Cobbold SP, Graca L, Lin C-Y, Adams E, Waldmann H.
Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance.
Transplant International 16:66-75.
Novitzky N, Davison GM, Hale G, Waldmann H.
Immune reconstitution at 6 months following T-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome.
Transplantation. 74(11): 1551-9.
Hale G, Slavin S, Goldman JM, Mackinnon S, Giralt S, Waldmann H.
Alemtuzumab (Campath-1H) for treatment of lymphoid malignancies in the age of nonmyeloablative conditioning?
Bone Marrow Transplant. 30(12): 797-804.
Chakrabarti S, Avivi I, Mackinnon S, Ward K, Kottaridis PD, Osman H, Waldmann H, Hale G, Fegan CD, Yong K, Goldstone AH, Linch DC, Milligan DW.
Respiratory virus infections in transplant recipients after reduced-intensity conditioning with Campath-1H: high incidence but low mortality.
Br J Haematol. 119(4): 1125-32.
Symons JA, Adams E, Tscharke DC, Reading PC, Waldmann H, Smith GL.
The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model.
J. Gen. Virol. 83: 2833-2844.
Lin, C-Y., Graca, L., Cobbold, SP., Waldmann, H.
Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.
Nature Immunology 3(12): 1208-1213.
Published online here.
Waldmann H.
Transplantation - caught in the crossfire! (News and Views)
Nature Immunology 3: 803-804.
Chakrabarti S, Mackinnon S, Chopra R, Kottaridis PD, Peggs K, O'Gorman P, Chakraverty R, Marshall T, Osman H, Mahendra P, Craddock C, Waldmann H, Hale G, Fegan CD, Yong K, Goldstone AH, Linch DC, Milligan DW.
High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution.
Blood. 99(12): 4357-63.
Waldmann H.
Reprogramming the immune system.
Immunol Rev. 185(1): 227-35.
Lundin J, Kimby E, Bjorkholm M, Broliden PA, Celsing F, Hjalmar V, Mollgard L, Rebello P, Hale G, Waldmann H, Mellstedt H, Osterborg A.
Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL).
Blood. 100(3): 768-73.
Waldmann H.
A personal history of the CAMPATH-1H antibody.
Med Oncol. 2002;19 Suppl:S3-9.
Graca, L., Cobbold, SP., and Waldmann, H.
Identification of regulatory T cells in tolerated allografts.
J. Exp. Med. 195(12): 1641-1646.
Graca, L., Thompson, S., Lin, C-Y., Adams, E., Cobbold, S., Waldmann H.
Both CD4+CD25+ and CD4+CD25- regulatory cells mediate dominant transplantation tolerance.
J. Immunol. 168(11): 5558-5565.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Tone M, Tone Y, Babik JM, Lin CY, Waldmann H.
The Role of Sp1 and NF-kB in Regulating CD40 Gene Expression.
J Biol Chem. 277(11): 8890-7.
Zelenika, D., Adams, E. Humm, S., Graca, L., Thompson, S., Cobbold, S*., Waldmann, H*.
*joint senior authors
Regulatory T cells over-express a subset of Th2 gene transcripts
J. Immunol. 168: 1069-1079.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Chakraverty R, Peggs K, Chopra R, Milligan DW, Kottaridis PD, Verfuerth S, Geary J, Thuraisundaram D, Branson K, Chakrabarti S, Mahendra P, Craddock C, Parker A, Hunter A, Hale G, Waldmann H, Williams CD, Yong K, Linch DC, Goldstone AH, Mackinnon S.
Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen.
Blood. 99(3): 1071-8.
Hale G, Cobbold S, Novitzky N, Bunjes D, Willemze R, Prentice HG, Milligan D, MacKinnon S, Waldmann H.
CAMPATH-1 antibodies in stem-cell transplantation.
Cytotherapy. 3(3): 145-64.
Waldmann, H.
Tolerance induction with CD4 monoclonal antibodies. in
Autoimmunity and Emerging Diseases.
Steinman L., (ed.)
Center for Study of Emerging Diseases CSED: Ch. 20: 240-246.
Kottaridis PD, Milligan DW, Chopra R, Chakraverty RK, Chakrabarti S, Robinson S, Peggs K, Verfuerth S, Pettengell R, Marsh JC, Schey S, Mahendra P, Morgan GJ, Hale G, Waldmann H, De Elvira MC, Williams CD, Devereux S, Linch DC, Goldstone AH, MacKinnon S.
In vivo CAMPATH-1H prevents GvHD following nonmyeloablative stem-cell transplantation.
Cytotherapy. 3(3): 197-201.
Chakraverty R, Robinson S, Peggs K, Kottaridis PD, Watts MJ, Ings SJ, Hale G, Waldmann H, Linch DC, Goldstone AH, Mackinnon S.
Excessive T cell depletion of peripheral blood stem cells has an adverse effect upon outcome following allogeneic stem cell transplantation.
Bone Marrow Transplant. 28(9): 827-34.
Willis F, Marsh JC, Bevan DH, Killick SB, Lucas G, Griffiths R, Ouwehand W, Hale G, Waldmann H, Gordon-Smith EC.
The effect of treatment with Campath-1H in patients with autoimmune cytopenias.
Br J Haematol. 114(4): 891-8.
Waldmann, H., Cobbold, SP.
Approaching tolerance in transplantation.
Int. Arch. Allergy Immunol. 126: 11-22.
Waldmann, H.
Therapeutic approaches for transplantation.
Current Opinion in Immunology 13: 606-610.
Isaacs, JD., Greer, S., Sharma, S., Symmons, D., Smith, M., Johnston, J., Waldmann, H., Hale, G., Hazleman, BL.
Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia.
Arthritis and Rheumatism 44: 1998-2008.
Zelenika, D., Adams, E., Humm, S., Lin, C-Y., Waldmann, H. and Cobbold, SP.
The role of CD4+ T cell subsets in determining transplantation rejection or tolerance.
Immunol. Rev. 182: 164-179.
Taylor PA., Lees CJ., Waldmann, H., Noelle, RJ., Blazar, BR.
Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions.
Blood 98: 467-74.
Barge, RMY., Brouwer, RE., Beersma, MFC., Starrenburg, CWJ., Zwinderman, AH., Hale, G., Waldmann, H., den Ottolander, GJ., Falkenburg, JHF., Willemze, R., Fibbe, WE.
Comparison of allogeneic T cell-depleted peripheral blood stem cell and bone marrow transplantation: effect of stem cell source on short- and long-term outcome.
Bone Marrow Transplantation 27: 1053-1058.
Waldmann, H., Cobbold, SP., Fairchild, P. and Adams, E.
Therapeutic aspects of tolerance.
Current Opinions in Pharmacology 1: 392-397.
Graca, L. and Waldmann, H.
Dominant transplantation tolerance.
Graft 4: 174-179.
Waldmann, H. and Cobbold, S.
Regulating the immune response to transplants: a role for CD4+ regulatory cells?
Immunity 14: 399-406.
Waldmann, H., Hale, G., Cobbold, S.
Appropriate targets for monoclonal antibodies in the induction of transplantation tolerance.
Phil. Trans. R. Soc. Lond. B, 356: 1-5.
Tone, M., Tone, Y., Fairchild, PJ., Wykes, M., Waldmann, H.
Regulation of CD40 function by its isoforms generated through alternative splicing.
Proc. Natl. Acad. Sci. (USA) 98(4): 1751-1756.
Thiru, S., Waldmann, H. (Editors)
Pathology and Immunology of Transplantation and Rejection
Pub: Blackwell Science, Oxford.
Waldmann, H., Cobbold, S., and Hale, G.
Graft versus host disease: its control and prospects for allogeneic bone marrow transplantation.
in Pathology and Immunology of Transplantation and Rejection
Thiru, S., Waldmann, H. (Editors)
Pub: Blackwell Science, Oxford.
pp 438-445.
Hale, G., Waldmann, H.
From laboratory to clinic: the story of CAMPATH-1
in Molecular Medicine Vol 40: Diagnostic and Therapeutic Antibodies
George, AJT., Urch, CE., Eds.
Pub: Humana Press Inc. Totowa, NJ.
pp 243-266.
Fairchild, PJ., Brook, FA., Gardner, RL., Graca, L., Strong, V., Tone, Y., Tone, M., Nolan, KF., Waldmann, H.
Directed differentiation of dendritic cells from mouse embryonic stem cells.
Current Biology 10(3): 1515-18.
Graca, L., Honey, K., Adams, E., Cobbold, SP., Waldmann, H.
Cutting Edge: Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.
J. Immunol. 165: 4783-4786.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Kottaridis PD, Milligan DW, Chopra R, Chakraverty RK, Chakrabarti S, Robinson S, Peggs K, Verfuerth S, Pettengell R, Marsh JC, Schey S, Mahendra P, Morgan GJ, Hale G, Waldmann H, de Elvira MC, Williams CD, Devereux S, Linch DC, Goldstone AH, Mackinnon S.
In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation.
Blood. 96(7):2419-25.
Hale G, Jacobs P, Wood L, Fibbe WE, Barge R, Novitzky N, Toit C, Abrahams L, Thomas V, Bunjes D, Duncker C, Wiesneth M, Selleslag D, Hidajat M, Starobinski M, Bird P, Waldmann H.
CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells.
Bone Marrow Transplant. 26(1):69-76.
Cull GM, Haynes AP, Byrne JL, Carter GI, Miflin G, Rebello P, Hale G, Waldmann H, Russell NH.
Preliminary experience of allogeneic stem cell transplantation for lymphoproliferative disorders using BEAM-CAMPATH conditioning: an effective regimen with low procedure-related toxicity.
Br J Haematol. 108(4):754-60.
Calne R, Moffatt SD, Friend PJ, Jamieson NV, Bradley JA, Hale G, Firth J, Bradley J, Smith KG, Waldmann H.
Prope tolerance with induction using Campath 1H and low-dose cyclosporin monotherapy in 31 cadaveric renal allograft recipients.
Nippon Geka Gakkai Zasshi. 101(3):301-6.
Davison, GM., Novitzky, N., Kline, A., Thomas, V., Abrahams, L., Hale, G., and Waldmann, H.
Immune reconstitution after allogeneic bone marrow transplantation depleted of T cells.
Transplantation 69: 1341-1347.
Waldmann, H.
Transplantation (Editorial Overview).
Current Opinion in Immunology 12: 509-510.
Fairchild PJ., and Waldmann, H.
Dendritic cells and prospects for transplantation tolerance.
Current Opinion in Immunology 12: 528-535.
Fairchild PJ., and Waldmann, H.
Extrathymic signals regulate the onset of T cell repertoire selection.
Eur. J. Immunol. 30(7): 1948-56.
Waldmann, H.
Prospects for the application of antibodies in medicine.
From Methods in Molecular Medicine Vol 40: Diagnostic and therapeutic antibodies.
pp 63-72.
George AJT., and Urch, CE. (Eds) Humana Press Inc., Totowa NJ.
Powell MJ, Thompson SA, Tone Y, Waldmann H, Tone M.
Posttranscriptional Regulation of IL-10 Gene Expression Through Sequences in the 3'-Untranslated Region.
J Immunol. 165(1):292-296.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Tone M, Powell MJ, Tone Y, Thompson SA, Waldmann H.
IL-10 Gene Expression Is Controlled by the Transcription Factors Sp1 and Sp3.
J Immunol. 165(1):286-291.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Williams, RJ., Clarke, E., Blair, A., Evely, R., Hale, G., Waldmann, H., Brookes, S., Pamphilon, DH.
Impact on T cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PBSC collections: comparison with CAMPATH-1M and CAMPATH-1G.
Cytotherapy 2(1): 5-14.
Waldmann, H., and Cobbold, S.
T-cell regulation and transplantation tolerance.
Current Opinions in Organ Transplantation 5: 83-89.
Honey, K., Bemelman, F., Cobbold, S.P., and Waldmann, H.
High dose bone marrow transplantation induces deletion of antigen-specific T cells in a Fas independent manner.
Transplantation, 69(8): 1676-1682.
Honey, K., Cobbold, S.P., and Waldmann, H.
Dominant tolerance and linked suppression induced by therapeutic antibodies do not depend on Fas-FasL interactions.
Transplantation, 69(8):1683-1689.
Byrne JL, Stainer C, Cull G, Haynes AP, Bessell EM, Hale G, Waldmann H, Russell NH.
The effect of the serotherapy regimen used and the marrow cell dose received on rejection, graft versus host disease and outcome following unrelated donor bone marrow transplantation for leukaemia.
Bone Marrow Transplant. 25(4): 411-7.
Dick AD, Meyer P, James T, Forrester JV, Hale G, Waldmann H, Isaacs JD.
Campath-1H therapy in refractory ocular inflammatory disease.
Br J Ophthalmol. 84:107-109
Wise, M., Cobbold, S. & Waldmann, H.
Tolerance induction with CD4 monoclonal antibodies: a role for minors in linked suppression.
In: Minor Histocopatibility Antigens (Eds Roopenian, D.C. & Simpson, E.) Landis BioScience, Austin, Texas, pp141-147.
James, LC., Hale, G., Waldmann, H., and Bloomer, AC.
1.9A structure of the therapeutic antibody CAMPATH-1H Fab in complex with a synthetic peptide antigen
J. Mol. Biol. 289: 293-301.
Friend PJ, Hale G, Chatenoud L, Rebello P, Bradley J, Thiru S, Phillips JM, Waldmann H.
Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection.
Transplantation. 68(11):1632-7
Calne R, Moffatt SD, Friend PJ, Jamieson NV, Bradley JA, Hale G, Firth J, Bradley J, Smith KG, Waldmann H
Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients.
Transplantation 68(10):1613-6
Rebello PR, Hale G, Friend PJ, Cobbold SP, Waldmann H.
Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection.
Transplantation 68(9):1417-20
Coles AJ, Wing M, Smith S, Coraddu F, Greer S, Taylor C, Weetman A, Hale G, Chatterjee VK, Waldmann H, Compston A
Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis.
Lancet 354(9191):1691-5
Waldmann H
Transplantation tolerance-where do we stand?
Nat Med 5(11):1245-8.
Honey K, Cobbold SP, Waldmann H
CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression.
J Immunol 163(9):4805-10.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Lockwood CM, Elliott JD, Brettman L, Hale G, Rebello P, Frewin M, Ringler D, Merrill C, Waldmann H
Anti-adhesion molecule therapy as an interventional strategy.
Clin Immunol 93(2):93-106.
Tone M, Nolan KF, Walsh LA, Tone Y, Thompson SA, Waldmann H
Structure and chromosomal location of mouse and human CD52 genes.
Biochim Biophys Acta 1446(3):334-40.
Conaghan PG, Sommer S, McGonagle D, Veale D, Waldmann H, Hale G, Goodfield M, Emery P, Isaacs J
The relationship between pityriasis rubra pilaris and inflammatory arthritis: case report and response of the arthritis to anti-tumor necrosis factor immunotherapy.
Arthritis Rheum 42(9):1998-2001.
Milstein C, Waldmann H
Optimism after much pessimism: what next?
Curr Opin Immunol 11(5):589-91
Green A, Clarke E, Hunt L, Canterbury A, Lankester A, Hale G, Waldmann H, Goodman S, Cornish JM, Marks DI, Steward CG, Oakhill A, Pamphilon DH
Children with acute lymphoblastic leukemia who receive T-cell-depleted HLA mismatched marrow allografts from unrelated donors have an increased incidence of primary graft failure but a similar overall transplant outcome.
Blood 94(7):2236-46
Coles AJ, Wing MG, Molyneux P, Paolillo A, Davie CM, Hale G, Miller D, Waldmann H, Compston A
Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis.
Ann Neurol 46(3):296-304
Honey K, Cobbold SP, Waldmann H
Dominant regulation: a common mechanism of monoclonal antibody induced tolerance?
Immunol Res 20(1):1-14
Naparstek E, Delukina M, Or R, Nagler A, Kapelushnik J, Varadi G, Strauss N, Cividalli G, Aker M, Brautbar C, Waldmann H, Hale G, Slavin S
Engraftment of marrow allografts treated with Campath-1 monoclonal antibodies.
Exp Hematol 27(7):1210-8
Parry-Jones N, Haque T, Ismail M, Jones L, Hale G, Waldmann H, Gordon-Smith EC, Crawford DH, Marsh JC
Epstein-Barr virus (EBV) associated B-cell lymphoproliferative disease following HLA identical sibling marrow transplantation for aplastic anaemia in a patient with an EBV seronegative donor.
Transplantation 67(10):1373-5
Novitzky N, Thomas V, Hale G, Waldmann H
Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect.
Transplantation 67(4):620-6
Hudde, T., Rayner, S.A., Weber, M.,Isaacs, J.D., Waldmann, H., Larkin, D.F.P., and George, A.J.T.
Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium.
Gene Therapy 6: 939-943.
Babik, J.M., Adams, E., Tone, Y., Fairchild, P.J., Tone, M., and Waldmann, H.
Expression of murine IL-12 is regulated by translational control of the p35 subunit
J. Immunol. 162: 4069-4078.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Gilliland, L.K., Walsh, L.A., Frewin, M.R., Wise, M.P., Tone, M., Hale, G., and Waldmann, H.
Elimination of the immunogenicity of therapeutic antibodies.
J. Immunol. 162: 3663-3671.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Lefkovits, I., and Waldmann, H.
Limiting dilution analysis of cells of the imune system.
Oxford University Press, Oxford.
Tone, M., Diamond. L.E., Wlash, L.A., Thompson, S.A.J., Shanahan, E.M., Logan, J.S., and Waldmann, H.
High level transcription of the complement regulatory protein CD59 requires an enhancer located in intron 1.
J. Biol. Chem. 274: 710-716.
Abstract | Article | PDF
(Article and PDF formats only available to JBC subscribers)
Waldmann, H., Gilliland, L.K., Cobbold, S.P., and Hale, G.
in Fundamental Immunology, Fourth Edition., Ed. Paul, W.E.,
Lipincott-Raven Publishers, Philadelphia, Chapter 45: 1511-1533.
Wise, M., Zelenika, D., Bemelman, F., Latinne, D., Bazin, H., Cobbold, S., and Waldmann, H.
CD4 T cells can reject major histocompatibility complex class I incompatible skin grafts.
Eur. J. Immunol. 29: 156-167.
Elliott JD, Lockwood CM, Hale G, Waldmann H
Semi-specific immuno-absorption and monoclonal antibody therapy in ANCA positive vasculitis: experience in four cases.
Autoimmunity 28(3):163-71.
Lockwood, C.M., Thiru, S., Stewart, S., Drummond, C., Elliott, J., Hale, G., Flower, C.D., Wraight, E.P., and Waldmann, H.
Refractory Wegener's granulomatosis: a model for shorter term therapy of autoimmune diseases.
Journal of the Royal College of Physicians 32: 473.
Cheetham, G.M.T., Hale, G., Waldmann, H. and Bloomer, A.C.
Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart.
J. Mol. Biol. 284: 85-99.
Hale, G., Zhang, M-J., Bunjes, D., Prentice, HG., Spence, D., Horowitz, M., Barrett, J., and Waldmann, H.
Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection.
Blood, 92(12): 4581-4590.
Nolan, K., Greaves, D.R. & Waldmann, H.
The human interleukin 18 gene IL 18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.
Genomics, 51, 161-163.
Waldmann, H.
The applications of antibodies in medicine.
In: Diagnostic and Therapeutic Antibodies (Ed. George A.J.T.) Molecular Medicine Series, Humana Press.
Isaacs, J. D., Greenwood, J. & Waldmann, H.
Therapy with monoclonal antibodies. II. The contribution of Fc-gamma receptor binding and the influence of ChI and CH3 domains on in vivo effector function.
J. Immunol. 161, 3862-3869
Isaacs, J.D. & Waldmann, H.
Regaining self-control. (editorial letter)
British Journal of Rheumatology 37, 926-929
Wise, M.P., Bemelman, F., Cobbold, S.P., and Waldmann, H.
Linked suppression can operate through indirect recognition.
J. Immunol. 161: 5813-5816.
Clarke, E., Potter, M.N., Hale, G., Waldmann, H., Lankester, A., Cornish, J.M., Steward, C.G., Marks, D.I., Oakhill, A. and Pamphilon, D.H.
Double T cell depletion of bone marrow using sequential positive and negative cell immunoaffinity or CD34+ cell selection followed by CAMPATH-1M: effect on CD34+ cells and progenitor cell recoveries.
Bone Marrow Transplant. 22: 117-124.
Dick, A.D., Duncan, L., Hale, G., Waldmann, H., and Isaacs, J.
Neutralizing TNF-alpha activity modulates T-cell phenotype and function in experimental autoimmune uveoretinitis.
Cell. Immunol. 185: 101-113.
Zelenika,D., Adams, E., Mellor, A., Simpson, E., Chandler, P., Stockinger, B., Waldmann, H., & Cobbold, S. P.
Rejection of H-Y disparate skin grafts by monospecific CD4+ T helper 1 (Th1) and T helper 2 (Th2) cells: no requirement for CD8+ T cells or B cells.
J. Immunol. 161: 1868-1874.
Cobbold, S. & Waldmann, H.
Infectious tolerance.
Curr. Opinion Immunol., 10 (5): 518-524.
Waldmann, H.
Limiting Dilution Analysis
in Encyclopedia of Immunology 2nd Ed.
Academic Press.
In the press.
Woods, M., Guy, R., Waldmann, H., Glennie, M., and Alexander, D.R.
A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2, IL-4, and IL-10 secretion and expression of CD25, CD40L, and CD69.
Cell. Immunol. 185:101-113.
Calne, R., Friend, P., Moffatt, S., Bradley, A., Hale, G., Firth, J., Bradley, J., Smith, K. and Waldmann, H.
Prope tolerance, perioperative Campath 1H, and low-dose cyclosporin monotherapy in renal allograft patients.
The Lancet 351:1701-1702.
Waldmann, H., Bemelman, F., and Cobbold, S.
Tolerance induction with CD4 monoclonal antibodies.
in Immunological Tolerance
Novartis Foundation Symposium 215, 146-158.
pub. Wiley, Chichester.
Revillard, J-P., Adorini, L., Goldman, M., Kabelitz, D., and Waldmann, H.
Apoptosis: potential for disease therapies.
Immunology Today 19: 291.
Adorini, L., Goldman, M., Kabelitz, D., Revillard, J-P., and Waldmann, H.
Apoptosis, tolerance and immunoregulation - integrated pathways for immune system homeostasis.
The Immunologist 6/2: 92-94.
Waldmann, H., & Cobbold, S.
How do monoclonal antibodies induce tolerance? A role for Infectious Tolerance?
Ann. Rev. immunol. 16: 619-44.
[Abstract] [Full Text] [PDF]
Hale, G. & Waldmann, H.
Risks of developing Epstein-Barr virus-related lymphoproliferative disorders after T-cell-depleted marrow transplants. CAMPATH Users.
Blood 91(8): 3079-83.
Fournel, S., Robinet, E., Bonnefoy-Berard, N., Assossou, O., Flacher, M., Waldmann, H., Bismuth, G., & Revillard, J.P.
A noncomitogenic CD2R monoclonal antibody induces apoptosis of activated T cells by a CD95/CD95-L-dependent pathway.
J. Immunol. 160(9): 4313-21.
Bemelman, F., Honey, K., Adams, E., Cobbold, S., & Waldmann, H.
Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.
J. Immunol. 160: 2645-2648.
Mehta, J., Powles, R., Treleaven, J., Horton, C., Shepherd, V., Hale, G., Waldmann, H., and Singhal, S.
Autologous transplantation with CD52 monoclonal antibody-purged marrow for acute lymphoblastic leukaemia: long-term follow-up.
Leuk. Lymphoma 25: 479-86.
Isaacs, JD., Burrows, N., Wing, M., Keogan, M.T., Rebello, PRUB., Watts, RA.,Pye, RJ., Norris, P., Hazelman, BL., Hale, G. & Waldmann H.
Humanized anti-CD4 monoclonal antibody therapy of autoimmune and inflammatory disease.
Clin. Exp. Immunol. 110: 158-166.
Hale, G. & Waldmann, H.
Use of Ceprate CD34-positive selection system for depletion of T cells in allogeneic transplantation [letter; comment]
Bone Marrow transplant. 20(8):709-10.
Genestier, L., Paillot, R., Bonnefoy-Berard, N., Meffre, G., Flacher, M., Fevre, D., Liu, YL., Le Bouteiller, P., Waldmann, H., Englehard, V.H., Banchereau, J., & Revillard, JP.
Fas-independent apoptosis of activated T cells induced by antibodies to the HLA Class I alpha1 domain.
Blood 90(9): 3629-3639.
Davies, J.D., Cobbold, S.P. & Waldmann, H.
Strain variation in susceptibility to monoclonal antibody-induced transplantation tolerance.
Transplantation 63, 1570-1573
Dyer, M.J.S., Kelsey, S.M., Mackay, H.J., Emmett, E., Thornton, P., Hale, G. & Waldmann, H.
In vivo 'purging' of residual disease in CLL with Campath-1H.
British Journal of Haematology 97, 669-672.
Genestier-L ; Paillot-R ; Bonnefoy-Berard-N ; Waldmann-H ; Revillard-JP -L
T cell sensitivity to HLA class I-mediated apoptosis is dependent on interleukin-2 and interleukin-4.
Eur-J-Immunol .1997 Feb; 27(2): 495-9.
Hale, G. & Waldmann, H.
Use of monoclonal antibodies for preventing graft rejection and inducing graft-host tolerance. In: Clinical Bone Marrow and Blood Stem Cell Transplantation, 2nd ed. Ed. K. Atkinson
Cambridge University Press
Killick, S., Marsh, J.C.W., Hale, G., Waldmann, H., Kelly, S.J., & Gordon-Smith, E.C.
Sustained remission of severe resistant auto-immune neutropenia with Campath-1H.
Br. J. Haematol. 97(2): 306-8.
Scully, R., Cobbold, S.P., Mellor, A.L., Wissing, M., Arnold, B. & Waldmann, H.
A role for Th2 cytokines in the suppression of CD8+ T-cell mediated graft rejection.
Eur.J.Imm. 27, 1663-1670.
Tone, M., Thompson, S.A.J., Tone, Y., Fairchild, P.J. & Waldmann, H.
Regulation of interleukin-18 (interferon- - inducing factor) gene expression.
J. Immunol. 159(12): 6156-63.
Waldmann, H., Cobbold, S.P. & Hale, G.
Grant versus Host Disease. Its control and prospects for allogeneic bone marrow transplantation
in: Immunology and Pathology of Transplantation. Ed. S. Thiru & H. Waldmann. pub. Blackwell Science
Chen, Z.K., Cobbold, S.P., Waldmann, H.& Metcalfe, S.
Amplification of natural regulatory immune mechanisms for transplantation tolerance.
Transplantation 62, 1200-1206.
Cornish-JM ; Pamphilon-DH ; Potter-MN ; Steward-CG ; Goodman-S ; Green-A ; Goulden-P ; Goulden-N ; Knechtli-C ; Hale-G ; Waldmann-H ; Oakhill-A
Unrelated donor bone marrow transplant in childhood ALL. The role of T-cell depletion.
Bone-Marrow-Transplant .1996 Nov; 18 Suppl 2: 31-5.
Davies, J.D., Leong, L.Y.W., Mellor, A., Cobbold, S.P. & Waldmann, H.
T-cell suppression in transplantation tolerance through linked recognition.
J. Immunol. 156, 3602-3607.
Davies, J.D., Martin, G., Phillips, J., Marshall, S.E, Cobbold, S.P. & Waldmann, H.
T cell regulation in adult transplantation tolerance.
J. Immunol., 157, 529-533
Fournel, S., Vincent, C., Assossou, O., Gorman, S.D., Robinet, E., Phillips, J. M., Flacher, M., Cordier, G., Waldmann, H. & Revillard, J.P.
CD4 mAbs prevent progression of alloactivated CD4+ T cells into the S phase of the cell cycle without interfering with early activation signals.
Transplantation .1996 Oct 27; 62(8): 1136-43.
Hale, G. & Waldmann, H.
Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection.
Bone Marrow Transplantation 17, 305-308.
Hamblin, M., Marsh, J.C.W., Lawler, M., McCann, S.R., Wickham, N., Dunlop, L., Ball, S., Davies, E.G., Hale, G., Waldmann, H. & Gordon-Smith, E.C.
Campath-1G in vivo confers a low incidence of graft-versus-host disease associated with a high incidence of mixed chimaerism after bone marrow transplantation for severe aplastic anaemia using HLA-identical sibling donors.
Bone Marrow Transplantation 17, 819-824.
Isaacs-JD ; Hazleman-BL ; Chakravarty-K ; Grant-JW ; Hale-G ; Waldmann-H
Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.
J-Rheumatol .1996 Jun; 23(6): 1103-6.
Isaacs-JD ; Wing-MG ; Greenwood-JD ; Hazleman-BL ; Hale-G ; Waldmann-H
A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans.
Clin-Exp-Immunol .1996 Dec; 106(3): 427-33.
Lockwood, C.M., Thiru, S., Steard, S., Hale, G., Isaacs, J., Wraight, P., Elliott, J. & Waldmann, H.
Treatment of refractory Wegener's granulomatosis with humanized monoclonal antibodies.
Q. J. Med. 89, 903-912.
Marshall, S.E., Cobbold, S.P., Davies, J.D., Martin, G.M., Phillips, J.M. & Waldmann, H.
Tolerance and suppression in a primed immune system.
Transplantation 62, 1614-1621.
Moreau-T ; Coles-A ; Wing-M ; Isaacs-J ; Hale-G ; Waldmann-H ; Compston-A
Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis.
Brain .1996 Feb; 119 ( Pt 1): 225-37.
Oakhill, A., Pamphilon, D.H., Potter, M.N., Steward, C.G., Goodman, S., Green, A., Goulden, P., Goulden, N.J., Hale, G., Waldmann, H. and Cornish, J.M.M.
Unrelated donor bone marrow transplantation for children with relapsed acute lymphoblastic leukaemia in second complete remission.
British Journal of Haematology 94 574-578.
Moreau, T., Coles, A., Wing, M., Thorpe, J., Miller, D., Moseley, I., Isaacs, J., Hale, G., Clayton, D., Scolding, N., Waldmann, H., Compston, A.
CAMPATH-1H in multiple sclerosis.
Mult. Scler. 1(6): 357-65.
Tone, Y., Thompson, S.A.J., Babik, J.M., Nolan, K.F., Tone, M., Raven, C. & Waldmann, H.
Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes.
Eur.J.Immunol., 26, 1222-1227.
Waldmann, H. & Cobbold, S.
How may immunosuppression lead to tolerance? The war analogy.
In Immune Tolerance (ed Banchereau, J., Dodet, B., Schwartz, R., Trannoy E.) Elsevier, Paris, pp 221-227.
Wing, M., Moreau, T., Greenwood, J., Smith, R., Hale, G., Isaacs, J., Waldmann, H., Lachmann, P. & Compston, A.
The mechanism of first-dose cytokine relase syndrome by CAMPATH 1-H: involvement of CD16 (Fc-gamma RIII) and CD11a/CD18 (LFA-1) on NK cells.
J. Clin. Invest.98: 2819-2826
Wing, M.G., Waldmann, H., Isaacs, J., Compston, D.A.S. & Hale, G.
Ex-vivo whole blood cultures for predicting cytokine release syndrome: dependence on target antigen and antibody isotype.
J. Therapeutic Immunology 98: 2819-2826.
Brons-IG ; Davies-HF ; Rasmussen-A ; Watson-CJ ; Thiru-S ; Cobbold-SP ; Waldmann-H ; Calne-RY
Islet allografting in the dog model: potential therapies for tolerance induction.
Transplant-Proc .1995 Feb; 27(1): 609-10.
Brons-IG ; Davies-HS ; Watson-CJ ; Cobbold-SP ; Waldmann-H ; Calne-RY
Substantial peripheral T-cell depletion before grafting is beneficial in islet transplantation.
Transplant-Proc .1995 Dec; 27(6): 3181.
Chatenoud-L ; Waldmann-H ; Emmrich-F
Tolerance induction in the adult: 'danger' at Le Bischenberg [published erratum appears in Immunol Today 1995 Apr;16(4):172]
Immunol-Today .1995 Mar; 16(3): 121-3.
Cobbold, S.P., Adams, E., Marshall, S.E., Davies, J.D. & Waldmann, H.
Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8.
Immunol. Revs. 148, 1-29.
Diamond, L.E., McCurry, K.R., Oldham, E.R., Tone, M., Waldmann, H. Platt, J.L. & Logan, J.S.
Human CD59 expressed in transgenic mouse hearts inhibits the activation of complement.
Transplant. Immunology 3, 305-312.
Hale-G ; Waldmann-H
Availability of Campath-1 antibodies for bone marrow transplantation [letter; comment]
Bone-Marrow-Transplant .1995 Feb; 15(2): 327.
Isaacs, JD., Hale, G., Waldmann, H., Dick, AD., Haynes, R., Forrester, JV., Watson, P., Meyer, PA.
Monoclonal antibody therapy of chronic intraocular inflammation using CAMPATH-1H [letter]
Br. J. Opthamol. 79(11): 1054-5.
Kooyman, D.L., Byrne, G.W., Maclellan, S., Nielsen, D., Tone, M., Waldmann, H., Coffman, T.M., McCurry K.R., Platt, J.L. & Logan, J.S.
In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium.
Science 269, 89.
Newman, DK., Isaacs, JD., Watson, PG., Meyer, PA., Waldmann, H.
Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H.
Eye 9: 564-9.
Routledge, E. & Waldmann, H.
The effect of aglycosylation on the immunogenicity of a humanised therapeutic CD3 antibody.
Transplantation 60, 847.
Spencer-A ; Szydlo-RM ; Brookes-PA ; Kaminski-E ; Rule-S ; van-Rhee-F ; Ward-KN ; Hale-G ; Waldmann-H ; Hows-JM ; et-al
Bone marrow transplantation for chronic myeloid leukemia with volunteer unrelated donors using ex vivo or in vivo T-cell depletion: major prognostic impact of HLA class I identity between donor and recipient.
Blood .1995 Nov 1; 86(9): 3590-7.
Watson-CJ ; Davies-HF ; Cobbold-SP ; Rasmussen-A ; Rebello-PR ; Thiru-S ; Waldmann-H ; Calne-RY ; Metcalfe-SM
CD4 and CD8 monoclonal antibody therapy in the dog: strategies to induce tolerance to renal allografts.
Transplant-Proc .1995 Feb; 27(1): 123-4.
Abbs, I.C., Clark, M., Waldmann, H., Chatenoud, L., Koffman, C.G. & Sacks, S.H.
Sparing of first dose effect of monovalent anti-CD3 antibody used in allograft rejection is associated with a diminished release of pro-inflammatory cytokines
J. Therapeutic Immunology 6: 325-332
Brons-IG ; Davies-HS ; Makisalo-H ; Rasmussen-A ; Cobbold-SP ; Waldmann-H ; Calne-RY
Transplantation of immunomodulated dog islets.
Transplant-Proc .1994 Apr; 26(2): 754.
Chen-Z ; Cobbold-S ; Waldmann-H ; Metcalfe-S
Combined use of RS61443 with CD4 and CD8 MAbs to generate tolerance to skin xenografts from rat
Transplant-Proc .1994 Aug; 26(4): 2433-4.
Chen-Z ; Cobbold-SP ; Waldmann-H ; Metcalfe-SM
Tolerance induction in concordant heart-xenografted mice by CD4 and CD8 monoclonal antibodies.
Transplant-Proc .1994 Jun; 26(3): 1199-200.
Davies-HS ; Cobbold-SP ; Watson-CJ ; Metcalfe-SM ; Rebello-PR ; Thiru-S ; McNair-R ; Rasmussen-A ; Waldmann-H ; Calne-RY
Production, selection, and testing of monoclonal antibodies to canine leukocytes in the dog kidney allograft model.
Transplant-Proc .1994 Aug; 26(4): 1941-2.
Fuller, B.E., Girald, A.A., Waldmann, H., Cobbold, S.P. & Kong, Y-C.M.
Depletion of CD4+ and CD8+ cells eliminates immunologic memory of thyroiditogenicity in murine experimental autoimmune thyroiditis.
Autoimmunity 19, 161-168.
Gorman, S.D., Frewin, M.R., Cobbold, S.P. & Waldmann, H.
Isolation and expression of cDNA encoding the canine CD4 and CD8 alpha antigens.
Tissue Antigens. 43(3): 184-8
Greenwood,J., Gorman, S.D., Routledge,E.G., Lloyd, I.S. and Waldmann H.
Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H. Effects on complement lysis..
J. Therapeutic Immunology 1:247-256
Hale, G & Waldmann,H.
CAMPATH-1 monoclonal antibodies in bone marrow transplantation.
J. Hematother. 3(1): 15-31
Hale, G. & Waldmann, H.
Control of graft-versus-host disease and graft rejection by T cell depletion of donor and recipient with Campath-1 antibodies. Results of matched sibling transplants for malignant diseases.
Bone Marrow Transplant. 13(5): 597-611
Isaacs,J. & Waldmann, H.
Helplessness as a strategy for avoiding antiglobulin responses to therapeutic monoclonal antibodies.
J. Therapeutic Immunology 1. 303-312
Jacobs, P., Wood, L., Fullard, L., Waldmann, H. & Hale, G.
T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease.
Bone Marrow Transplant. 13(6): 763-9
Marshall, S.E. & Waldmann, H.
Monoclonal antibodies in therapeutic transplantation.
In Kupciek Weginski ed. New Immunosuppressive modalities in anti-rejection approaches in organ transplantation. Reed Intelligence Unit. USA Therapeutic Transplantation.
Moreau, T., Thorpe, J., Miller, D., Moseley, I., Hale, G., Waldmann, H., Clayton, D., Wing, M., Scolding, N. & Compston, A.
Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis.
Lancet. 344: 298-301
Scully, R., Qin, S., Cobbold, S.P. & Waldmann, H.
Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells.
Europ. J. Immunol 24: 2383-2392
Waldmann, H., Cobbold, S.P. and Hale, G.
What can be done to prevent Graft versus Host Disease?
Current Opinions in Immunology 6:777-784
Watson, C.J., Cobbold, S.P., Davies, H.S., Rebello, P.R., Thiru, S., McNair, R., Rasmussen, A., Waldmann, H., Calne, R.Y., & Metcalfe, S.M.
Immunosuppression of canine renal allograft recipients by CD4 and CD8 monoclonal antibodies.
Tissue Antigens. 43(3): 155-62
Greenwood, J., Clark, M. & Waldmann, H.
Structural motifs involved in IgG effector functions.
Eur.J.Immunol. 23: 1098-1104
Lockwood, C.M., Thiru S., Isaacs J.D., Hale G. & Waldmann H.
Humanised monoclonal antibody therapy for intractable systemic vasculitis.
Lancet. 341: 1620-2
Bolt S., Routledge E., Lloyd I., Chatenoud L., Pope H., Gorman S., Clark, M. and Waldmann, H.
The generation of humanised, non-mitogenic CD3 monoclonal antibody which retains in-vitro immunosuppressive properties.
Europ. J. Immunol. 23: 403-11
Chen, Z., Cobbold, S., Waldmann, H. & Metcalfe, S.
Stability of tolerance in mice generated by CD4 and CD8 monoclonal antibody treatment: cell transfer experiments.
Transplantation Proceedings 25, 790-791.
Cullis, J.G., Szydlo, R,M., Cross, N.C.P., Marks, D.I., Schwarer, A.P., Hughes, T.P., MacKinnon, S., Hale, G., Waldmann, H., Hows ,J.M., Barrett, A.J. & Goldmann, J.M.
Matched unrelated donor bone marrow transplantation for chronic myeloid leukaemia in chronic phase: comparison of ex vivo and in vivo T-cell depletion .
Bone Marrow Transplant. 11 Suppl 1: 107-11
Davies, J.D. & Waldmann, H.
Monoclonal Antibodies in Transplantation.
In Rose, M. & Yacoub, M. Eds. Immunology of Heart and Lung Transplantation. Edward Arnold, 93-116.
Greenwood, J., Clark, M. & Waldmann, H.
Structural motifs involved in human IgG antibody effector functions.
Eur.J.Immunol. 23(5), 1098.
Hale, G. & Waldmann, H. for the CAMPATH users
Monoclonal antibodies for preventing graft rejection and inducing tolerance.
In ""Clinical Bone Marrow Transplantation: A Textbook"" (ed. K. Atkinson) Cambridge University Press.
Hayward, A.R., Shriber, M., Cooke, A. & Waldmann, H.
Prevention of diabetes but not insulitis in NOD mice injected with antibody to CD4:
J. Autoimmun. 6: 301-10
Hutchings, P.R., Cooke, A., Dawe, K., Waldmann, H. & Roitt, I.M.
Active suppression induced by anti-CD4.
Eur.J.Immunol. 23(4) 965-8.
Lim, S.H., Hale, G., Marcus, R.E., Waldmann, H. & Baglin, T.P.
CAMPATH-1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura.
Br.J.Haematol. 84(3): 542-4
O'Neill, J.K., Baker, D., Davison, A.N., Allen, S.J., Butter, C., Waldmann, H. & Turk, J.L.
Control of immune-mediated disease of the central nervous system with monoclonal (CD4-specific) antibodies.
J-Neuroimmunol. 45(1-2): 1-14
Parish NM; Hutchings PR; Waldmann H; Cooke A.
Tolerance to IDDM induced by CD4 antibodies in nonobese diabetic mice is reversed by cyclophosphamide.
Diabetes. 1993 42(11): 1601-5
Qin, S., Cobbold, S.P. Pope, H., Elliott, J., Kioussis, D. & Waldmann, H.
Infectious Transplantation Tolerance.
Science. 12; 259: 974-7
Sims, M.J., Hassal, D.G., Brett, S., Rowan, W., Lockyer, M.J., Angel, A., Hale, G., Waldmann, H. & Crowe, S.
Selection and functional characterisation of humanised CD18 antibody. A humaized CD18 antibody can block function without cell destruction.
J. Immunol. 151(4), 2296-2308.
Waldmann H. & Cobbold, S.
Monoclonal antibodies for the induction of transplantation tolerance.
Curr.Opin.Immunol. 5(5): 753-8.
Waldmann H., Qin Shixin and Cobbold SP.
Monoclonal antibodies for the therapeutic induction of tolerance.
in Bach JF ed. ""Monoclonal Antibodies and peptide therapy in Autoimmune Diseases. Marcel Dekker. Immunol. Ser. 59, 85-99. Chapter 5 pp 85-99.
Waldmann, H. & Cobbold,S.
The use of monoclonal antibodies to achieve immunological tolerance.
Trends Pharmacol. Sci. 14(5): 143-8
Waldmann, H., Qin, S., Leong, Y.W.L. & Cobbold, S.P.
Reprogamming the immune system
in Thomas Donnell ed. Application of Basic Science to Hematopoiesis and Treatment of Disease. Raven Press.
Watson, C.J., Cobbold, S.P., Davies, H.S,, Rebello, P.R., Waldmann, H., Calne, R.Y. & Metcalfe, S.M.
CD4 and CD8 monoclonal antibody therapy: strategies to prolong renal allograft survival in the dog.
Br.J.Surg. 80(11): 1389-92.
Xia, M.Q., Hale, G. & Waldmann, H.
Efficient complement-mediated lysis of cells containing the CAMPATH-1 (Cdw52) antigen.
Mol. Immunol. 30(12), 1089-96.
Xia, M.Q., Hale, G., Lifely, M.R., Ferguson, M.A., Campbell, D., Packman, L. & Waldmann, H.
Structure of the CAMPATH-1 antigen, glycosylphosphatidylinositol anchored glycoprotein which is an exceptionally good target for complement lysis
Biochem.J. ; 293 : 633-40.
Chen, Z., Cobbold, S.P., Metcalfe, S. & Waldmann, H.
Tolerance in the mouse to MHC mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8.
Eur. J. Immunol. 22, 805-810.
Cobbold S.P., Qin Shixin., Leong, L.Y.W ., Martin, G. & Waldmann, H.
Reprogramming the Immune System for peripheral tolerance with CD4 and CD8 monoclonal antibodies.
Immunol. Rev 129: 165-201.
Hutchings, P., O'Reilly, L., Parish, N.M., Waldmann, H. & Cooke, A.
The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to b cells in NOD mice.
Eur. J. Imunol. 22, 1913-1918.
Isaacs, J.D., Clark, M.R., Greenwood, J. & Waldmann, H.
Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential.
Journal of Immunology, 148, 3062-3071.
Isaacs, J.D., Watts, R.A., Hazleman, B.L., Hale, G., Keogan, M.T., Cobbold, S.P. & Waldmann, H.
Humanised monoclonal antibody therapy for rheumatoid arthritis.
Lancet .340; 748-752
Leong LYW., Qin Shixin., Cobbold SP., and Waldmann H.
Classical Transplantation Tolerance in the Adult. The interaction between myeloablation and immunosuppression.
Europ. J. Immunol. : 22: 2825-30
Lockwood, C.M., Thru, S., Isaacs, J.D., Hale, G. & Waldmann, H.
Humanised monoclonal antibody therapy for intractable systemic vasculitis.
Lancet 341, 1620-1622.
Nabozny, G.H., Cobbold, S.P., Waldmann, H. & Kong, Yi-chi.
Suppression in Murine Experimental Autoimmune Thyroiditis: In Vivo Inhibition of CD4+ T Cell-Mediated Resistance by a Nondepleting Rat CD4 Monoclonal Antibody.
Cellular Immunology 138. .
Tone, M., Walsh, L.A. & Waldmann, H.
Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation.
J. Mol. Biol. 227: 971-976
Waldmann, H.
Selective depletion of alloreactive cells in transplantation.
In Solheim et al. eds. The HLA system in clinical transplantation. Chapter 22. Springer Verlag.
Waldmann, H., Qin Shixin, Leong, L.Y.W. & Cobbold, S.P.
In vivo use of monoclonal antibodies for modulation of the immune response.
Forum trends in experimental and clinical medicine 2: 250- 261
Waldmann, H., Qin, S. & Cobbold, S.
Monoclonal antibodies as agents to reinduce tolerance in immunity.
Journal of Autoimmunity , 5, 93-102.
Walsh, L.A., Tone, M., Thiru, S. & Waldmann, H.
The CD59 antigen - a multifunctional molecule.
Tissue Antigens. 40: 213-20
Willemze, R., Richel, D.J., Falkenburg, J.H.F., Hale, G., Waldmann, H., Zwaan, F.E. & Fibbe, W.E.
In vivo use of Campath-1-G to prevent graft-versus-host disease and graft rejection after bone marrow transplantation.
Bone Marrow Transplantation. 9: 255-61
Wise, M. Benjamin, R., Qin, S., Cobbold, S. & Waldmann, H.
Tolerance induction in the peripheral immune system.
Molecular Mechanisms of Immunological Self-Recognition. Vogel H and Alt F eds. Acad. Press Inc.p 149-155.
Friend, P.J., Waldmann, H., Cobbold, S., Tighe, H., Rebello, P., Wight, D., Gore, S., Pollard, S., Lim, S. & Johnston, P.
The anti-IL-2 receptor monoclonal antibody YTH-906 in liver transplantation.
Transplant. Proc. 23, 1390-1392.
Friend, P.J., Waldmann, H., Hale, G., Cobbold, S., Rebello, P., Thiru, S., Jamieson, N.V., Johnston, P.S. & Calne, R.Y.
Reversal of allograft rejection using the monoclonal antibody, CAMPATH-1G.
Transplant Proc. 23, 2253-2254.
Gorman, S.D., Clark, M.R., Routledge, E.G., Cobbold, S.P. & Waldmann, H.
Reshaping a therapeutic CD4 antibody.
Proc. Natl. Acad. Sci. 88, 4181-4185.
Meng-Qi, X., Tone, M., Packman, L., Hale, G. & Waldmann, H.
Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone.
Eur. J. Immunol. 21, 1677-1684.
Meri, S., Waldmann, H. & Lachmann, P.
Distribution of Protection (CD59), a Complement Membrane Attack Inhibitor, in Normal Human Tissues.
Laboratory Investigation. 65, 532-537.
Routledge, E.G., Lloyd, I., Gorman, S., Clark, M. & Waldmann, H.
A Humanized Monovalent CD3 Antibody which can Activate Homologous Complement.
Eur. J. Immunol. 21, 2717-2725
Waldmann, H.
Limiting Dilution Analysis.
Encyclopedia of Immunology. 979-981.
Waldmann, H., Cobbold, S., Qin, S. & Leong, L.
Transplantation Tolerance with Monoclonal Antibodies.
in Burlingham W. Ed. Monoclonal Antibody Therapy. CRC Press. (in Press).
Walsh, L. A., Tone, M. & Waldmann, H.
Transfection of human CD59 complementary DNA into rat cells confers resistance to human complement.
Eur. J. Immunol. 21, 847-850.
Watt, S.M., Sala-Newly, G., Hoang, T., Gilmore, D.J., Grunert, F., Nagel, G., Murdoch, S.J., Tchilian, E., Lennox, E.S. & Waldmann, H.
CD66 identifies a neutrophil - specific epitope within the hematopoietic system that is expressed by members of the carcinoembryonic antigen family of adhesion molecules.
Blood, 78, 63-74.
Bindon, C.I., Hale, G. & Waldmann, H.
Complement activation by immunoglobulin does not depend solely on Clq binding.
Eur. J. Immunol. 20, 277-281.
Clark, M., Bolt, S., Tunnacliffe, A. & Waldmann, H.
Use of bispecific monoclonal antibodies to treat hematological malignancies: a model system using CD3 transgenic mice.
In: Bispecific antibodies and targeted cellular cytotoxicity: Second international conference, J.L. Romet-Lemonne, M.W. Fanger & D.M. Segal (Eds), pp. 243-247.
Cobbold, S.P., Hale, G., Clark, M.R. & Waldmann, H.
Purging in auto- and allografts: monoclonal antibodies which use human complement and other natural effector mechanisms.
Prog. Clin. Biol. Res. 333. 139-151.
Cobbold, S.P., Martin, G. & Waldmann, H.
The Induction of Skingraft Tolerance in MHC-Mismatched or Primed Recipients: primed T-cells can be tolerized in the periphery with CD4 and CD8 antibodies.
Eur. J. of Immunol. 20, 2747-2755.
Cobbold, S.P., Qin, S. & Waldmann, H.
Reprogramming the immune system for tolerance with monoclonal antibodies.
Seminars in Immunology 2, 377-387.
Dyer, M.J., Hale, G., Marcus, R. & Waldmann, H.
Remission Induction in Patients with Lymphoid Malignancies Using Unconjugated CAMPATH-1 Monoclonal Antibodies.
Leukemia and Lymphoma 2, 179-193.
Hale, G., Xia, M-Q., Tighe, H.P., Dyer, M.J.S. & Waldmann, H.
The CAMPATH-1 Antigen (CDw52).
Tissue Antigens 35, 118-127.
Hutchings, P.R., Simpson, E., O'Reilly, L.A., Waldmann, H., Lund, T. & Cooke, A.
The Involvement of Ly2+ T Cells in Beta Cell Destruction.
J. of Autoimmunity 3, 101-109.
Mackinnon, S., Hows, J.M., Goldman, J.M., Arthur, C.K., Hughes, T., Apperley, J.F., Jones, L., Batchelor, J.R., Brookes, P., Catovsky, D., Galton, D.A.G., Bidwell, J., Bradley, B., Cleaver, S., Hale, G. & Waldmann, H.
Bone Marrow Transplantation for Chronic Myeloid Leukemia: The Use of Histocompatible Unrelated Volunteer Donors.
Exp. Hematol. 18, 421-425.
Mathieson, P.W., Cobbold, S.P., Hale, G., Clark, M.R., Oliveira, D.B.G., Lockwood, C.M. & Waldmann, H.
Monoclonal Antibody Therapy in Systemic Vasculitis.
New Eng J. Med. 323, 250-254.
Meri, S., Morgan, B.P., Davies, A., Daniels, R.H., Olavesen, M.G., Waldmann, H. & Lachmann, P.J.
Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.
Immunology 71, 1-9.
Qin, S., Wise, M., Cobbold, S., Leong, L., Kong, Yi-Chi, Parnes, J.R. & Waldmann, H.
Induction of tolerance in peripheral T cells with monoclona antibodies.
Eur. J. of Immunol. 20, 2737-2745.
Routledge, E., Lloyd, I., Gorman, S. & Waldmann, H.
A monovalent humanized antibody bispecific for the human CD3 antigen complex.
In: Bispecific antibodies and targetted cellular cytotoxicity. Second international conference, J.L. Romet-Lemonne, M.W. Fanger & D.M. Segal (Eds), pp. 157-164.
Waldmann, H.
(Editor). Introduction: Therapeutic approaches to the induction of specific unresponsiveness.
Seminars in Immunology 2., 375. Saunders Scientific Publications.
Waldmann, H., Cobbold, S., Clark, M., Hale, G., Qin, S. & Wise, M.
The Generation of Immunological Tolerance as a Therapeutic Procedure.
Horizons in Medicine, Ed. L.K. Borysiewicz.
Waldmann, H., Hale, G., Cobbold, S., Clark, M., Qin, S., Benjamin, R. & Dyer, M.J.S.
Monoclonal Antibody Therapy for the Prevention of Graft-vs.-Host Disease. (Ed. S J Burakoff., H.J. Deeg, J. Ferrara and K. Atkinson, Publ. Marcel Dekker Inc. N.Y. & Basel.
Hematology, 12, 277-293.
Brewer, Y., Palmer, A., Taube, D., Welsh, K., Bewick, M., Bindon, C., Hale, G., Waldmann, H., Dische, F., Parsons, V. & Snowden, S.
Effect of Graft Perfusion with Two CD45 Monoclonal Antibodies on Incidence of Kidney Allograft Rejection.
The Lancet, II, 935-937.
Bruggemann, M., Caskey, H.M., Teale, C., Waldmann, H., Williams, G.T., Surani, M.A. & Neuberger, M.S.
A repertoire of monoclonal antibodies with human heavy-chains from transgenic mice.
Proc. Natl. Acad. Sci. 86, 6709-6713.
Bruggemann, M., Teale, C., Bindon, C., Clark, M. & Waldmann, H.
A Matched Set of Rat/Mouse Chimeric Antibodies: Identification and Biological Properties of Rat H Chain Constant Regions m. g1, g2a, g2b, g2c, e, and a1
J. of Immunol. 142, 3145-3150.
Bruggemann, M., Winter G., Waldmann, H. & Neuberger, M.S.
The Immunogenicity of chimeric antibodies.
J. Exp. Med. 170, 2153-2157.
Clark, M., Bindon, C., Dyer, M., Friend, P., Hale, G., Cobbold, S., Calne, R. & Waldmann, H.
The improved lytic function and in vivo efficacy of monovalent monoclonal CD3 antibodies.
Eur. J. Immunol. 19, 381-388.
Cobbold, S., Barel, D. & Waldmann, H.
Manipulating the immune system with monoclonal antibodies: mouse models for immunotherapy.
In T Cells Ed. M. Feldman. Pub. John Wiley.
Davies, A., Simmons, D.L., Hale, G., Harrison, R.A., Tighe, H., Lachmann, P.J. & Waldmann, H.
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.
J. Exp. Med. 170, 637-654.
Day, M.J., Elson, C.J., Cobbold, S.P. & Waldmann, H.
Adoptive Suppression of Erythrocyte Autoantibodies in Lyt-2+ Depleted Recipients.
Autoimmunity 3, 39-45.
Dyer, M.J.S., Hale, G., Hayhoe, F.G.J. & Waldmann, H.
Effects of CAMPATH-1 Antibodies in vivo in Patients with Lymphoid Malignancies: Influence of Antibody Isotype.
Blood 73, 1431-1439.
Flynn, J.C., Conaway, D.H., Cobbold, S., Waldmann, H. & Kong, Y.M.
Depletion of L3T4+ and Lyt-2+ Cells by Rat Monoclonal Antibodies Alters the Development of Adoptively Transferred Experimental Autoimmune Thyroiditis.
Cell. Immunol. 122, 377-390.
Frame, J.N., Collins, N.H., Cartagena, T., Waldmann, H., O.Reilly, R.J., Dupont, B. & Kernan, N.A.
T cell depletion of human bone marrow. Comparison of Campath-1 plus complement, anti T cell ricin A chain immunotoxin, and soybean agglutinin alone or in combination with sheep erythrocytes or immunomagnetic beads.
Transplantation 47, 984-988.
Friend, P.J., Hale, G., Waldmann, H., Gore, S., Thiru, S., Joysey, V., Evans, D.B. & Calne, R.Y.
Campath -1M prophylactic use after kidney transplantation. A randomized controlled clinical trial.
Transplantation. 48, 248-253.
Hale G., Xia. M. & Waldmann, H.
Purification and preliminary characterisation of the CAMPATH-1 antigen.
Tissue Antigens 33, 290.
Hale, G., Cobbold, S. & Waldmann, H.
Cluster analysis using percentage or mean fluorescence: comparison indicates that future workshop analysis could be improved and simplified.
Tissue Antigens 33, 363.
Kong, Y.M., Giraldo, A.A., Waldmann, H., Cobbold, S.P. & Fuller, B.
Resistance to experimental autoimmune thyroiditis: L3T4+ cells as mediators of both thyroglobulin-activated and TSH-induced suppression.
Clin. Immunol. Immunopathol. 51, 38-54.
Kong, Y.M., Waldmann, H., Cobbold, S., Giraldo, A.A., Fuller, B.E. and Simon, L.L.
Pathogenic mechanisms in murine autoimmune thyroiditis: short- and long-term effects of in vivo depletion of CD4+ cells and CD8+ cells.
Clin. Exp. Immunol. 77, 428-433.
Kyle, V., Coughlan, R.J., Tighe, H., Waldmann, H. & Hazleman, B.L.
Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis.
Ann. Rheum. Dis. 48, 428-429.
Qin, S., Cobbold, S., Benjamin, R. & Waldmann, H.
Induction of classical transplantation tolerance in the adult.
J. Exp. Med. 169, 779-794.
Liew, F.Y., Millot, S., Lelchuk, R.,Cobbold, S. & Waldmann, H.
Clin. Exp. Immunol. 75, 438-443 (1989)
Effect of CD4 monoclonal antibody in vivo on lesion development, delayed-type hypersensitivity and interleukin 3 production in experimental murine cutaneous leishmaniasis.
Waldmann, H.
Manipulation of T-cell responses with monoclonal antibodies.
Ann. Revs. Immunol. 7, 407-444.
Waldmann, H., Cobbold, S.P. & S. Qin,
Tolerance Induction Using CD4 and CD8 Monoclonal Antibodies.
Progress in Immunology VII, 147-155.
Waldmann, H., Cobbold, S.P., Qin, S., Benjamin, R.J. & Wise, M.
Tolerance Induction in the Adult Using Monoclonal Antibodies to CD4, CD8 and CD11a (LFA-1).
54th Symposium on Quantitative Biology : Immunological Recognition : Cold Spring Harbour Lab. Press. LIV, 885-892.
Williams, R.O., Whyte, A. & Waldmann, H.
Resistance to collagen-induced arthritis in DBA/1 mice by intraperitoneal administration of soluble type II collagen involves both CD4+ and CD8+ T lymphocytes.
Autoimmunity. 4, 237-245.
Zamoyska, R., Waldmann, H. & Matzinger, P.
Peripheral tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses.
Eur. J. Immunol. 19, 111-117
Benjamin, R.J., Shixin, Q., Wise, M.P., Cobbold, S.P. & Waldmann, H.
Mechanisms of monoclonal antibody-facilitated tolerance induction: a possible role for the CD4 (L3T4) and CD11a (LFA-1) molecules in self-non-self discrimination.
Europ. J. Immunol. 18, 1079-1088.
Bindon, C.I., Hale, G. & Waldmann, H.
Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies.
Eur. J. Immunol. 18, 1507-1514.
Bruggemann, M., Delmastro-Galfre, P., Waldmann, H. & Calabi, F.
Sequence of a rat immunoglobulin g2c heavy chain constant region cDNA: extensive homology to mouse g3.
Eur. J. Immunol. 18, 317-319.
Friend PJ., Tighe H., Waldmann H., Lim S., D St. J Collier., Cambell D., Thiru S. & Calne RY.
Monoclonal antibodies that recognise activated human lymphocytes-experimental and clinical studies.
Trans. proc. XX No1 Supp1 pp 265-266
Gilliland, L.K., Clark, M.R. & Waldmann, H.
Universal bispecific antibody for targeting tumour cells for destruction by cytotoxic T cells.
Proc. Natl. Acad. Sci. 85, 7719-7723.
Hale, G. Clark, M.R., Marcus, R., Winter, G., Dyer, M.J.S., Phillips, J.M., Riechmann, L. & Waldmann, H.
Remission Induction in Non-hodgkin Lymphoma with Reshaped Human Monoclonal Antibody CAMPATH-1H
Lancet II, 1394-1399.
Hale, G., Bindon, C., Clark, M., Dyer, M. & Waldmann, H.
Complement activation by monoclonal antibodies.
Sandoz 14, 30-41.
Hale, G., Cobbold, S.P. & Waldmann, H.
T Cell Depletion with Campath-1 in Allogeneic Bone Marrow Transplantation.
Transplantation 45, 753-759.
Riechmann, L. Clark, M., Waldmann, H., & Winter, G.
Reshaping human antibodies for therapy.
Nature 332, 323-327.
Waldmann, H., Cobbold, S., Benjamin, R. & Qin, S.
A Theoretical Framework for Self-tolerance and its Relevance to Therapy of Auto-immune Disease.
J. Autoimmunity 1, 623-629
Waldmann, H., Hale, G., Clark, M. et al
Monoclonal antibodies for Immunosuppression.
Progress in Allergy, 45, 16-30. Pub. S. Karger AG, Basel.
Aqel, N.M. Clark, M.R., Jones, D.B., Arno, J. & Waldmann, H.
Identification of Cells of the Human Mononuclear Phagocyte System with Rat Monoclonal Antibodies.
J. Pathology. 152, 265-273.
Bindon, C., Hale, G., Bruggemann, M. & Waldmann, H.
Human monoclonal IgG isotypes differ in complement activating function at the level of C4 binding as well as C1q.
J. Exp. Med. 168, 127-142.
Bindon, C.I., Hale, G., Hughes-Jones, N., Gorick, B. & Waldmann, H.
Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways.
Mol. Immunol. 24, 587-594.
Bruggemann, M., Williams, G.T., Bindon C.I., Clark, M.R., Walker, M.R., Jefferies, R., Waldmann, H. & Neuberger, M.S.
Comparison of the Effector Functions of Human Immunoglobulins Using a Matched Set of Chimeric Antibodies.
J. Exp. Med. 166, 1351-1361.
Clark, M., Gilliland, L. & Waldmann, H.
The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy.
Br. J. Cancer 56, 509.
Clark, M.R. & Waldmann, H.
T Cell Killing of Target Cells Induced by Hybrid Antibodies: A Comparison of Two Bispecific Monoclonal Antibodies.
J. Natl. Canc. Inst. 79, 1393-1401.
Cobbold, S.P., Hale, G. & Waldmann, H.
Non-lineage, LFA-1 family, and leucocyte common antigens: new and previously defined clusters.
Leucocyte Typing III Oxford University Press P. 780. McMichael A. ed.
Friend PJ., Tighe H., Lim S., ST J Collier, M., DeCurtins LK., Gilliland LK., Thiru S., Calne R., & Waldmann H.
The use of monoclonal antibodies against activated human T-cells following renal allografting in the baboon.
Transplant. Proc. XIX pp4317-4318
Friend, P.J., Calne, R.Y., Hale, G., Waldmann, H., Evans, D.B., Rolles, K., Thiru, S. & Gore, S.
Prophylactic Use of an Antilymphocyte Monoclonal Antibody Following Renal Transplantation: A Randomized Controlled Trial.
Transpl. Proc. XIX, 1898-1900.
Hale, G., Buckie, C., Lovat, P., Prospero, T. & Waldmann, H.
Epitope mapping of the human leucocyte common antigen by competitive binding and synergistic lysis.
. Oxford University Press, p. 811. McMichael A. ed.
Hale, G., Cobbold, S.P., Waldmann, H., Easter, G., Matejtschuk, P. & Coombs, R.R.A.
Isolation of low-frequency class-switch variants from rat hybrid myelomas.
J. Immunol. Methods 103, 59-67.
Kantwerk, G., Cobbold, S., Waldmann, H. & Kolb, H.
L3T4 and Lyt2 T cells are both involved in the generation of low dose streptozotocin-induced diabetes in mice.
Clin Exp. Immunol. 70, 585-592.
Leist, T.P., Cobbold, S.P., Waldmann, H., Aguet, M. & Zinkernagel, R.M.
Functional analysis of T lymphocyte subsets in antiviral host defence.
J. Immunol. 138, 2278-2281.
Lightman, S., Cobbold, S., Waldmann, H., et. al.
Do L3T4+ T cells act as effector cells in protection against influenza virus infection.
Immunology, 62, 139-144.
Moskophidis, D., Cobbold, S.P. Waldmann, H. & Lehmann-Grube, F.
Mechanism of Recovery from Acute Virus Infection: Treatment of Lymphocytic Choriomeningitis Virus-Infected Mice with Monoclonal Antibodies Reveals that Lyt-2+ T Lymphocytes Mediate Clearance of Virus and Regulate the Antiviral Antibody Response.
J. of Virol. 61, 1867-1874
Muller, I., Cobbold, S.P., Waldmann, H. & Kauffmann, S.H.E.
Impaired Resistance to Mycobacterium tuberculosis Infection after Selective in vivo Depletion of L3T4+ and Lyt-2+ T Cells.
Infection & Immunity 55, 2037-2041.
Nash, A.A., Jayasuriya, A., Phelan, J., Cobbold, S.P., Waldmann, H. & Prospero, T.
Different Roles for L3T4+ and Lyt2+ T Cell Subsets in the Control of an Acute Herpes Simplex Virus Infection of the Skin and Nervous System.
J. Gen. Virol. 68, 825-833.
Qin, Shixin, Cobbold, S.P., Tighe, H., Benjamin, R. & Waldmann, H.
CD4 monoclonal antibody pairs for immunosuppression and tolerance induction.
Europ. J. Immunol. 17, 1159-1165.
Tighe, H., Clark, M. & Waldmann, H.
Blocking of Cytotoxic T Cell Function by Monoclonal Antibodies Against the CD45 Antigen (T200/leukocyte-common antigen).
Transplantation 44, 818-823.
Tighe, H., Friend, P.J., Collier, St. J., Decurtins, M., Lim S., Cobbold, S.P., Thiru, S., Calne, R.Y. & Waldmann, H.
Delayed allograft rejection in primates treated with anti-IL2 receptor monoclonal antibody CAMPATH-6.
Transplantation 45, 226-228.
Waldmann, H., Cobbold, S.P. & Lefkovits, I.
Limiting dilution analysis.
GGB Klaus ed. IRL Press.
Waldmann, H., Cobbold, S.P., Qin, Shixin, et al
Peters D.K. ed. Monoclonal antibodies for depletion of specific subpopulations of lymphocytes.
Ciba Symposia Autoimmunity. p.194.
Waldmann, H., Hale, G. & Cobbold, S.P.
The immunobiology of bone marrow transplantation.
Leucocyte Typing III. Oxford University Press, p.932. McMichael A. ed.
Watt, S.M., Gilmore, D.J., Davis, J.M., Clark, M.R. & Waldmann, H.
Cell surface markers on haemopoietic precursors. Reagents for the isolation and analysis of progenitor cell subpopulations.
Mol. Cell. Probes 1, 297-326.
Apperley, J.F., Jones, L., Hale, G., Waldmann., H., Hows, J., Rombos, Y., Tsatalas, C., Marcus, R.E., Goolden, A.W.G., Gordon-Smith, E.C., Catovsky, D., Galton, D.A.G. & Goldman, J.M.
Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with CAMPATH-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse.
Bone Marrow Transplantation 1, 53-66.
Benjamin, R.J. & Waldmann, H.
Induction of tolerance by monoclonal antibody therapy.
Nature 320, 449-451.
Benjamin, R.J. Cobbold, S.P., Clark, M.R. & Waldmann, H.
Tolerance of Rat Monoclonal Antibodies: Implications for Serotherapy.
J. Exp. Med. 163, 1539-1552.
Bruggemann, M., Free, J., Diamond, A., Howard, J., Cobbold, S.P. & Waldmann, H.
Immunoglobulin heavy chain locus of the rat: Striking homology to mouse antibody genes.
Proc. Natl. Acad. Sci. 83, 6075-6079.
Clark, M. & Waldmann, H.
1986",,"in Methods in Hematology (ed Beverly, P.) pub. Churchill Livingstone 13, 1-20.
Cobbold, S.P., Martin, G. & Waldmann, H.
Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection: The depletion of T-cell subsets in vitro and in vivo1.
Transplantation 42, 239-247.
Cobbold, S.P., Martin, G., Qin, S., & Waldmann, H.
Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance.
Nature 323, 164-166.
Goldman, J.M., Waldmann, H. et al
Bone marrow transplantation for patients with chronic myeloid leukemia.
New Eng. J. Med. 314, 202-207.
Hale, G. & Waldmann, H.
Depletion of T Cells with CAMPATH-1 and Human Complement. Analysis of GVHD and Graft Failure in a Multi-centre Study.
Bone Marrow Transplantation 1 Suppl. 1, 93.
Hale, G., Edwards, J.C. & Waldmann, H.
Prevention of graft-versus-host disease by T cell depletion with CAMPATH-1. Overview of results using antibody produced in Cambridge.
Bone Marrow Transplantation in Malignant Disease (Ed. Edwards, C. & Nethersall, A. Pub Wellcome, 37-46.
Hale, G., Waldmann, H., Friend, P. & Calne, R.
Pilot study of CAMPATH-1, a rat monoclonal antibody that fixes human complement, as an immunosuppressant in organ transplantation.
Transplantation 42, 308-310.
Heit, W., Bunjes, D., Wiesneth, M., Schmeiser, T., Arnold, R., Hale, G., Waldmann, H. & Heimpel, H.
Ex vivo T-cell depletion with the monoclonal antibody CAMPATH-1 plus human complement effectively prevents acute graft-versus-host-disease in allogeneic bone marrow transplantation.
Brit. J. Haematol. 64, 479-486.
Muller, S., Cobbold, S., Waldmann, H. & Kauffman, S.H.E.
Role of T lymphocytes in protection against mycobacterium tuberculosis.
Immunobiology 173, 415.
Or, R., Cividalli, G., Brautbar, C., Weiss, L., Weschler, Z., Samuel, S., Hale, G., Waldmann, H., Rachmilewitz, E.A. & Slavin, S.
Bone Marrow Transplantation in beta-thalassemia major (TM) using T-cell depleted HLA-identical bone marrow allografts.
Bone Marrow Transplantation 1, Suppl. 337.
Slavin, S., Hale, G., Waldmann, H. et al
New approaches for the prevention of rejection and graft-versus-host disease in clinical bone marrow transplantation.
Israel J. Medical Sciences 22, 264-267.
Slavin, S., Naparstek, E., Cividalli, G., Weshler, Z., Weiss, L., Mumchoglu, M., Brautbar, C., Schlesinger, M., Hale, G., Waldmann, H. & Or, R.
The use of CAMPATH-1 for prevention of graft-vs-host disease (GVHD) and total lymphoid irradiation (TLI) for abrogation of host resistance to T-cell depleted allografts.
UCLA Symposia.
Slavin, S., Or, R., Weshler, Z., Hale, G. & Waldmann, H.
The use of total lymphoid irradiation for abrogation of host resistance to T-cell depleted marrow allografts .
Bone Marrow Transplantation 1, Suppl. 1, 98.
Waldmann H., Cobbold, S.
Bone Marrow Transplantation in Malignant Disease (Ed. Edwards, C. & Nethersall, A.).
Monoclonal antibodies and bone marrow transplantation. Pub. Wellcome, 29-36.
Wilson, A.B., Harris, J., Waldmann, H. & Coombs, R.R.A.
Direct antibody rosette forming reactions using monoclonal markers of lymphocyte subpopulations: methodology and applications illustrated by investigations with rat pan-T antibodies of the CAMPATH series.
J. Immunol. Methods. 92, 241-249.
Aqel, N.M., Ball, R.Y., Waldmann, H. & Mitchinson, M.J.
Identification of macrophages and smooth muscle cells in human atherosclerosis using monoclonal antibodies.
J. Path.. 146, 197-204.
Bindon, C.I., Hale, G., Clark, M.R. & Waldmann, H.
Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen: synergy and interference in complement-mediated lysis1.
Transplantation 40, 538-544.
Cobbold, S.P. & Waldmann, H.
Skin Allograft Rejection by L3/T4+ and Lyt-2+ T Cell subsets.
Transplantation 41, 634-639.
Hale, G. & Waldmann, H.
Human Complement Fixing Antibodies in Transplantation.
In: Hybridoma technology in the biosciences and medicine. Ed. Springer, T. Plenum Press.
Hale, G. Clark, M.R. & Waldmann, H.
Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.
J. Immunol. 134, 3056-3061.
Hale, G., Swirsky, D., Waldmann, H. & Chan, L.C.
Reactivity of rat monoclonal antibody CAMPATH-1 with human leukaemia cells and its possible application for autologous bone marrow transplantation.
Brit. J. Haematol. 60, 41-48.
Morgan, G., Linch, D.C., Knott, L.T., Davies, E.G., Sieff, C., Chessells, J.M., Hale, G., Waldmann, H. & Levinsky, R.J.
Successful haploidentical mismathced bone marrow transplantation in severe combined immunodeficiency: T-cell removal using CAMPATH-1 monoclonal antibody and E-rosetting.
Brit. J. Haematol.. 62, 421-430.
Slavin, S., Waldmann, H., Or, R. et al
Prevention of Graft-versus-Host disease in Allogeneic Bone Marrow Transplantation for Leukaemia by T Cell Depletion in vitro Prior to Transplantation.
Transpl. Proc. 17, 465-467.
Thierfelder, S., Cobbold, S.P., Kummer, U., Waldmann, H. & Schuh, R.
Antilymphocyte Antibodies and Marrow Transplantation. VII. Two out of Nine Monoclonal Anti-Thy 1 Antibodies Used for Pretreatment of Donor Marrow Suppressed Graft-versus-Host Reactions Without Added Complement.
Exper. Haematol. 13, 948-955.
Watt, S.M., Gilmore, D.J., Clark, M.R., Davis, J.M., Swirsky, D.M. & Waldmann, H.
Haemopoietic Progenitor Cell Heterogeneity Revealed by a Single Monoclonal Antibody, YW 13.1.1.
Mol. Biol. Med. 2, 351-368.
Aqel, N.M., Ball, R.Y., Waldmann, H. & Mitchinson, M.J.
Monocytic Origin of Foam Cells in Human Atherosclerotic Plaques.
Atherosclerosis 53, 265-271.
Aqel, N.M., Clark, M.R., Cobbold, S.P. & Waldmann, H.
Immunohistological Screening in the Selection of Monoclonal Antibodies: the Use of Isotype-Specific Antiglobulins.
J. Immunol. Methods 69, 207-214.
Bindon, C., Hale, G. & Waldmann, H.
Therapeutic potential of monoclonal antibodies to the leucocyte common antigen.
8th International Conference on Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Plenum.
Clark, M.R., Cobbold, S.P., Waldmann, H. & Coombs, R.R.A.
Detection of Monoclonal Antibodies Against Cell Surface Antigens: the Use of Antiglobulins Coupled to Red Blood Cells.
J. Immunol. Methods 66, 81-87.
Clark, M.R., Hale, G. & Waldmann, H.
Interaction of rat monoclonal antibodies with human killer cells.
8th International Conference on Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Planum.
Cobbold, S.P. & Waldmann, H.
Therapeutic potential of monovalent monoclonal antibodies.
Nature 308, 460-462.
Cobbold, S.P., Jayasuriya, A., Nash, A., Prospero, T.D. & Waldmann, H.
Therapy with monoclonal antibodies. Elimination of T-cell subsets in vivo.
Nature 312, 548-551.
Cobbold, S.P., Martin, G., Lovat, P.E. & Waldmann, H.
Immunosuppression with monoclonal antibodies - rules for effective serotherapy.
8th International Conference on Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Plenum.
Hale, G., Hoang, T., Prospero, T., Watt, S.M. & Waldmann, H.
Removal of T-cells from bone marrow for transplantation.
Mol. Biol. Med. 1, 305-319.
Lefkovits, I. & Waldmann, H.
Limiting dilution analysis of the cells of immune system. I. The clonal basis of the immune response.
Immunology Today 5, 265-268.
Levinsky, R.J., Morgan, D., Davies E.G., Waldmann, H. et al
Mismatched bone marrow transplantation for severe combined immunodeficiency - The Great Ormond Street Experience. Ed. Griscelli, C. & Vossen,
J. Excerpta Medica 393-399.
Matzinger, P., Zamoyska, R. & Waldmann, H.
Self tolerance is H-2 restricted.
Nature 308, 738-741.
Slavin, S., Or, R., Waldmann, H. et al
Elimination of graft versus host disease in matched allogeneic leukaemic transplant recipients using CAMPATH-1.
8th International Conference on Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Plenum.
Sullivan, C., Kenny, G. & Waldmann, H.
The role of the major histocompatibility complex in in vitro antibody responses; MHC restriction in responses involving linked recognition of antigenic determinants is not solely consequent to T-cell accessory cell restrictions.
Immunology 51, 351-360.
Sullivan, C.P. & Waldmann, H.
T-cell help mechanisms in the in vitro antibody response: the role of linked and non-linked recognition interactions.
Immunology 51, 343-350.
Waldmann, H. & Lefkovits, I.
Limiting dilution analysis of cells of the immune system II: What can be learnt?
Immunology Today 5, 295-298.
Waldmann, H., Cobbold, S.P., Wilson, A.B. Clark, M.R., Watt, S., Hale, G. & Tighe H.
Rat monoclonal antibodies for bone marrow transplantation -the CAMPATH series.
8th International Conference of Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Plenum.
Waldmann, H., Or R., Hale, G., Weiss, L. et al
Elimination of graft-versus-host disease by in vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1).
Lancet II, 483-486.
Zamoyska, R. & Waldmann H.
Allosuppression: evidence for the involvement of both 'noncytotoxic' and cytotoxic T cells.
Europ. J. Immunol. 14, 645-651.
Cobbold, S.P., Thierfelder, S. & Waldmann, H.
Immunosuppression with Monoclonal Antibodies: A Model to Determine the Rules for Effective Serotherapy.
Mol. Biol. Med. 1, 285-304.
Downie, D.M., Voak, D., Jarvis, J., Waldmann, H. & Spitz, M.
The Use of Monoclonal Antibodies in Human IgG in Blood Transfusion Serology.
Bio. Bull.. 4, 348-352.
Hale, G., Bright, S., Chumbley, G., Hoang, T.K. Metcalf, D., Munro, A.J. & Waldmann, H.
Removal of T Cells from Bone Marrow for Transplantation: A Monoclonal Antilymphocyte Antibody that Fixes Human Complement.
Blood 62, 873-882.
Hale, G., Swirsky, D.M., Hayhoe, F.G.J. & Waldmann, H.
Effects of Monoclonal Anti-lymphocyte Antibodies in in vivo Monkeys and Humans.
Mol. Biol. Med. 1, 321-334.
Hoang, T., Gilmore, D., Metcalf, D., Cobbold, S.P., Watt, S., Clark, M., Furth, M. & Waldmann, H.
Separation of Haemopoietic Cells from Adult Mouse Marrow by use of Monoclonal Antibodies.
Blood 61, 580-588.
Swirsky, D.M., Watt, S.M., Gilmore, D.J., Hayhoe, F.G.J. & Waldmann, H.
The Characterisation of Monoclonal Antibodies Against Haemopoietic cells: Comparison of an Immunoperoxidase Method with Fluorescence Activated Cell Sorting.
J. Immunol. Methods 61, 171-182.
Watt, S.M., Metcalf, D., Gilmore, D.J., Stenning, G.M., Clark, M.R. & Waldmann, H.
Selective Isolation of Murine Erythropoietin-responsive Progenitor Cells (CFU-E) with Monoclonal Antibodies.
Mol. Biol. Med. 1, 95-115.
Zamoyska, R., Waldmann, H. Prospero, T. & Lennox, E.
Identification of Phenotypically Distinct Subpopulations of Cytotoxic T Lymphocytes.
Mol. Biol. Med. 1, 137-150.
Waldmann, H. & Milstein, C.
Monoclonal antibodies I
in Clinical Aspects of Immunology. Eds. Lachmann, P.S. & Peters, K. Blackwell.
Waldmann, H., Munro, A.J. & Maurer, P.
The Thymus and its Influence on the Expression of Immune Response Genes.
Behring Institute Mitteilungen No. 70, 167-172.
Watt, S.M., Gilmore, D.J., Metcalf, D., Cobbold, S.P., Hoang, T.K. & Waldmann, H.
Segregation of Mouse Hemopoietic Progenitor Cells Using the Monoclonal Antibody, YBM/42.
J. Cell Physiol 115, 37-45.
Cobbold, S.P. & Waldmann, H.
A rapid solid-phase enzyme-linked binding assay for screening monoclonal antibodies to cell surface antigens.
J. Immunol. Methods 44, 125-133.
McConnell, I., Munro, A.J. & Waldmann, H.
The Immune System (A textbook of immunology).
Desaymard, C., Shinton, R.A. & Waldmann, H.
Differences in calcium requirements for B-cell tolerance and immunity.
Immunology 39, 61-65.
Takei, F., Waldmann, H. Lennox, E.S. & Milstein, C.S.
Monoclonal antibody H9/25 reacts with functional subsets of T and B cells: killer, killer precursor and plaque-forming cells.
Europ. J. Immunol. 10, 503-509.
Waldmann, H. & Phillips, J.
How Many T Cells Help One B Cell?
Springer Seminars in Immunopathology 3, 129-144.
Waldmann, H.
Interactions between T and B cells: a review.
Journal of Roy. Soc. Med. 72, 198-202.
Waldmann, H. & Lefkovits, I.
Limiting dilution analysis of cells in the immune system.
(monograph) Cambridge University Press,
Waldmann, H., Kenny, G., Brown, D. & Feinstein, A.
Restrictions in the helper activity of T-cells.
Proc. of the 12th Leukocyte Culture Conference 'Biochemistry and cell biology of leukocyte functions'. Ed. Mr. Quastel. Acad. Press, 403.
Waldmann, H., Munro, A.J. & Maurer, P.H.
The Role of MHC Gene Products in the Development of the T-cell Repertoire.
In Immunobiology of the Bone Marrow Transplantation, Vol. 25. Eds. Thierfelder, S., Rodt, H. & Kolb, H.J. Suppl. Haematology and Blood Transfusion. BLIT.
Waldmann, H., Pope, H., Bettles, C. & Davies, A.J.S.
The influence of thymus on development of MHC restrictions exhibited by T-helper cells.
Nature 277, 137-138.
Munro, A.J. & Waldmann, H.
The Major Histocompatibility System and the Immune Response.
Brit. Med. Bull. 34, 253-258.
Waldmann, H.
The Influence of the Major Histocompatibility Complex on the Function of T-helper Cells in Antibody Formation.
Immunological Rev. 42, 202-223.
Waldmann, H. & Howard, J.C.
Ed. Lennox, E.
In: Defence and Recognition, chapter entitled Cellular Basis of the Immune Response.
Waldmann, H., Pope, H., Brent, L. & Bighouse, K.
The influence of the major histocompatibility complex on lymphocyte interactions in antibody formation.
Nature 274, 166-168.
Lefkovits, I. & Waldmann, H.
B Cell Subsets in Nude Mice.
Immunology 32, 915.
Phillips, J. & Waldmann, H.
The monogamous T-helper cell.
Nature 268, 641-642.
Waldmann, H.
Conditions Determining the Generation and Expression of T Helper Cells.
Immunological Rev. 35, 121-145.
Waldmann, H. & Pope, H.
The influence of antigen presentation on the generation of T-helper cells with different functions.
Immunology 33, 721-725.
Waldmann, H. & Pope, H.
Can B-cell tolerance be induced by oligovalent thymus dependent antigens?
Immunology 32, 657-667
Waldmann, H., Pope, H. & Kenny, G.
Co-operation across histocompatibility differences: The role of inhibitory T cells in preventing successful T-B interaction.
Immunology 33, 129-139.
Desaymard, C. & Waldmann, H.
Evidence for the inactivation of precursor B-cells in high dose unresponsiveness.
Nature 264, 780-782.
Waldmann, H.
Breaking tolerance to self molecules' in
physiological effects of immunity against reproductive hormones. Eds. Edwards, R.G. & Johnson, M.H., Cambridge University Press, P.5-22.
Waldmann, H. Pope, H. & Lefkovits, I.
Limiting dilution analysis of helper T-cell function: II. An approach to the study of the function of single helper T-cells.
Immunology 31, 343-352.
Waldmann, H., Lefkovits, I. & Feinstein, A.
Restriction in the functions of single helper T cells.
Immunology 31, 353-362.
Waldmann, H., Pope, H. & Munro, A.J.
Cooperation across the histocompatibility barrier, H-2d T-cells primed to antigen in an H-2d environment can cooperate with H-2k B cells.
J. Exp. Med. 144, 1707-1711.
Waldmann, H., Poulton, P. & Desaymard, C.
Antigen-non-specific T-cell factor in B-cell activation: Origin, biological properties and failure to show a relationship to H-2.
Immunology 30, 723-733.
Lefkovits, I., Quintans, J., Munro, A. & Waldmann,, H.
T Cell-dependent Mediator and B-cell Clones.
Immunology 28, 1149-1154.
Slowe, A. & Waldmann, H.
The 'Intrinsic Adjuvanticity' and Immunogenicity of Trinitrophenylated Lipopolysaccharide.
Immunology 29, 825-834.
Waldmann, H.
T Cell-dependent Mediator in the Immune Response: III. The role of non-specific factor (NSF) in the in vitro immune response.
Immunology 28, 497-507.
Waldmann, H. & Lachmann, P.J.
The failure to show a necessary role for C3 in the in vitro antibody response.
Europ. J. Immunol. 5, 185-193.
Waldmann, H. & Munro, A.J.
B Cell Activation.
Transplant.Rev. 23, 213-222.
Waldmann, H. & Munro, A.J.
The Inter-relationship of Antigenic Structure, Thymus-Independence and Adjuvanticity: IV. A 'general model for B-cell induction'.
Immunology 28, 509--522.
Waldmann, H., & Pope, H.
Low dose unresponsiveness with a thymus independent antigen.
Nature 258, 730-731.
Waldmann, H., Lefkovits, I. & Quintans, J.
Limiting Dilution Analyses of Helper T-cell Function.
Immunology 28, 1135-1147.
Waldmann, H., Pope, H. & Munro, A.J.
Cooperation across the histocompatibility barrier.
Nature 258, 728-730.
Waldmann, H. & Munro, A.J.
T-cell dependent mediator in the immune response. II. Physical and biological properties.
Immunology 27, 53-64.
Waldmann, H. & Munro, A.J.
T-cell dependence of B-cell unresponsiveness in vitro.
Europ. J. Immunol. 4, 410-416.
Waldmann, H. & Munro, A.J.
T-cell Dependent Mediator in the Immune Response.
Nature 243, 356-357.
Waldmann, H., Munro, A.J. & Hunter, P.
Properties of educated T-cells. The ability of educated T-cells to facilitate the immune response to non-cross reacting antigens in vitro.
Europ. J. Immunol. 3, 167-172.

Last updated 17th November 2015