Professor Waldmann's Publications

Listed with most recent first:

Waldmann H.
2015
Mechanisms of immunological tolerance.
Clin Biochem. 2015 May 30. doi: 10.1016/j.clinbiochem.2015.05.019.
Meister M, Papatriantafyllou M, Nordström V, Kumar V, Ludwig J, Lui KO, Boyd AS, Popovic ZV, Fleming TH, Moldenhauer G, Nawroth PP, Gröne HJ, Waldmann H, Oelert T, Arnold B.
2015
Dickkopf-3, a tissue-derived modulator of local T-cell responses.
Front Immunol. 2015 Feb 24;6:78. doi: 10.3389/fimmu.2015.00078.
Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H.
2014
Tolerance induction to human stem cell transplants with extension to their differentiated progeny.
Nat Commun. 2014 Dec 1;5:5629. doi: 10.1038/ncomms6629.
Han SO, Li S, Brooks ED, Masat E, Leborgne C, Banugaria S, Bird A, Mingozzi F, Waldmann H, Koeberl D.
2014
Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade.
Hum Gene Ther. 2015 Jan;26(1):26-35. doi:10.1089/hum.2014.115.
Howie D, Waldmann H, Cobbold S.
2014
Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment.
Front Immunol. 2014 Aug 28;5:409. doi:10.3389/fimmu.2014.00409.
Waldmann H,.
2014
Drug minimization in transplantation: an opinion.
Curr Opin Organ Transplant. 2014 Aug;19(4):331-3.
Piotti G, Ma J, Adams E, Cobbold S, Waldmann H,.
2014
Guiding postablative lymphocyte reconstitution as a route toward transplantation tolerance.
Am J Transplant. 2014 Jul;14(7):1678-89.
Waldmann H,, Hilbrands R, Howie D, Cobbold S.
2014
Harnessing FOXP3+ regulatory T cells for transplantation tolerance.
J Clin Invest. 2014 Apr 1;124(4):1439-45.
Tone Y, Kidani Y, Ogawa C, Yamamoto K, Tsuda M, Peter C, Waldmann H,, Tone M.
2014
Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.
J Immunol. 2014 Apr 15;192(8):3915-24.
Whibley N, Maccallum DM, Vickers MA, Zafreen S, Waldmann H,, Hori S, Gaffen SL, Gow NA, Barker RN, Hall AM.
2014
Expansion of Foxp3(+) T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge.
Eur J Immunol. 2014 Apr;44(4):1069-83.
Ogawa C, Tone Y, Tsuda M, Peter C, Waldmann H,, Tone M.
2014
TGF-β-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2.
J Immunol. 2014 Jan 1;192(1):475-83.
Worthington JJ, Klementowicz JE, Rahman S, Czajkowska BI, Smedley C, Waldmann H, Sparwasser T, Grencis RK, Travis MA.
2013
Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.
PLoS Pathog. 2013;9(10):e1003675.
Howie D, Garcia Rueda H, Brown MH, Waldmann H,.
2013
Secreted and transmembrane 1A is a novel co-stimulatory ligand.
PLoS One. 2013 Sep 10;8(9):e73610.
Waldmann H,.
2013
Human monoclonal antibodies: the residual challenge of antibody immunogenicity.
Methods Mol Biol. 2014;1060:1-8.
Hilbrands R, Howie D, Cobbold S, Waldmann H,.
2013
Regulatory T cells and transplantation tolerance.
Immunotherapy. 2013 Jul;5(7):717-31.
Cobbold SP, Waldmann H,.
2013
Regulatory cells and transplantation tolerance.
Cold Spring Harb Perspect Med. 2013 Jun 1;3(6). pii: a015545.
Sakaguchi S, Vignali DA, Rudensky AY, Niec RE, Waldmann H,.
2013
The plasticity and stability of regulatory T cells.
Nat Rev Immunol. 2013 Jun;13(6):461-7.
Regateiro FS, Cobbold SP, Waldmann H.
2013
CD73 and adenosine generation in the creation of regulatory microenvironments.
Clin Exp Immunol. 2013 Jan;171(1):1-7.
Regateiro FS, Chen Y, Kendal AR, Hilbrands R, Adams E, Cobbold SP, Ma J, Andersen KG, Betz AG, Zhang M, Madhiwalla S, Roberts B, Waldmann H, Nolan KF, Howie D.
2012
Foxp3 expression is required for the induction of therapeutic tissue tolerance.
J Immunol. 2012 Oct 15;189(8):3947-56.
Chen Y, Adams E, Regateiro FS, Vaux DJ, Betz AG, Andersen KG, Waldmann H, Howie D.
2012
Activation rather than Foxp3 expression determines that TGF-ß-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering.
Eur J Immunol. 42(6):1436-48. doi: 10.1002/eji.201142207.
Agorogiannis EI, Regateiro FS, Howie D, Waldmann H, Cobbold SP.
2012
Th17 cells induce a distinct graft rejection response that does not require IL-17A.
Am J Transplant. 12(4):835-45.
Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S.
2012
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.
Immunity. 36(2):262-75.
Alkemade GM, Hilbrands R, Vandemeulebroucke E, Pipeleers D, Waldmann H, Mathieu C, Keymeulen B, Roep BO.
2011
Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients.
Diabetes Metab Res Rev. 27(8):925-7.
Kendal AR, Chen Y, Regateiro FS, Ma J, Adams E, Cobbold SP, Hori S, Waldmann H.
2011
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.
J Exp Med. Aug 29. doi: 10.1084/jem.20110767
Regateiro FS, Howie D, Cobbold SP, Waldmann H.
2011
TGF-ß in transplantation tolerance.
Curr Opin Immunol. Aug 10. 21839624.
Regateiro FS, Howie D, Nolan KF, Agorogiannis EI, Greaves DR, Cobbold SP, Waldmann H.
2011
Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-ß.
Eur J Immunol. 2011 Jul 19. doi: 10.1002/eji.201141512.
McIntosh JH, Cochrane M, Cobbold S, Waldmann H, Nathwani SA, Davidoff AM, Nathwani AC.
2011
Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine.
Gene Ther. Jun 30. doi: 10.1038/gt.2011.64.
Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, Rudensky AY, Ichinose H, Metzger D, Chambon P, Yoshimura A.
2011
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.
Nat Commun. 2:269.
Cobbold SP, Adams A and Waldmann H.
2011
Biomarkers of transplantation tolerance: more hopeful than helpful?
Front. Immun. 2:9. doi: 10.3389/fimmu.2011.00009
Kuhn C, You S, Valette F, Hale G, van Endert P, Bach JF, Waldmann H, Chatenoud L.
2011
Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance.
Sci Transl Med. 2011 Feb 2;3(68):68ra10. PubMed PMID: 21289272.
Honda T, Otsuka A, Tanizaki H, Minegaki Y, Nagao K, Waldmann H, Tomura M, Hori S, Miyachi Y, Kabashima K.
2011
Enhanced murine contact hypersensitivity by depletion of endogenous regulatory T cells in the sensitization phase.
J Dermatol Sci. 2011 Feb;61(2):144-7. Epub 2010 Nov 11. PubMed PMID: 21129920.
Lui KO, Fairchild PJ, Waldmann H.
2010
Prospects for ensuring acceptance of ES cell-derived tissues. 2010 Sep 30.
StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
Available from here. PubMed PMID: 20963944.
Greene MI, Waldmann H.
2010
Regulation of the immune response.
Curr Opin Immunol. 2010 Oct;22(5):549-51. Epub 2010 Oct 16. PubMed PMID: 20956073.
Peter C, Waldmann H, Cobbold SP.
2010
mTOR signalling and metabolic regulation of T cell differentiation.
Curr Opin Immunol. 2010 Sep 10. [Epub ahead of print] PubMed PMID: 20833524.
Kendal AR, Waldmann H.
2010
Infectious tolerance: therapeutic potential.
Curr Opin Immunol. 2010 Sep 7. [Epub ahead of print] PMID: 20829013.
Lui KO, Boyd AS, Cobbold SP, Waldmann H, Fairchild PJ.
2010
A Role for Regulatory T Cells in Acceptance of Embryonic Stem Cell-Derived Tissues Transplanted Across an MHC Barrier.
Stem Cells. 2010 Aug 24. [Epub ahead of print] PubMed PMID: 20737577.
2010
Waldmann H.
Tolerance: an overview and perspectives.
Nat Rev Nephrol. 2010 Aug 17. [Epub ahead of print] PubMed PMID: 20717099.
Cobbold, SP., Adams, E., Nolan, KF., Regateiro, FS., and Waldmann, H.
2010
Connecting the mechanisms of T cell regulation: dendritic cells as the missing link.
Immunological Reviews 236:203-218.
Somerfield J, Hill-Cawthorne GA, Lin A, Zandi MS, McCarthy C, Jones JL, Willcox M, Shaw D, Thompson SA, Compston AS, Hale G, Waldmann H, Coles AJ.
2010
A novel strategy to reduce the immunogenicity of biological therapies.
J Immunol. 1;185(1):763-8. Epub 2010 Jun 2. PubMed PMID: 20519651.
Condamine T, Le Texier L, Howie D, Lavault A, Hill M, Halary F, Cobbold S, Waldmann H, Cuturi MC, Chiffoleau E.
2010
Tmem176B and Tmem176A are associated with the immature state of dendritic cells.
J Leukoc Biol. 2010 May 28. [Epub ahead of print] PubMed PMID: 20501748.
Farquhar CA, Paterson AM, Cobbold SP, Garcia Rueda H, Fairchild PJ, Yates SF, Adams E, Saunders NJ, Waldmann H, Nolan KF.
2010
Tolerogenicity is not an absolute property of a dendritic cell.
Eur J Immunol. 2010 Jun;40(6):1728-37. PubMed PMID: 20373289.
Ponte JF, Ponath P, Gulati R, Slavonic M, Paglia M, O'Shea A, Tone M, Waldmann H, Vaickus L, Rosenzweig M.
2010
Enhancement of humoral and cellular immunity with an anti-glucocorticoid-induced tumour necrosis factor receptor monoclonal antibody.
Immunology. 2010 Jun;130(2):231-42. Epub 2010 Feb 26. PubMed PMID: 20201988; PubMed Central PMCID: PMC2878467.
Tomura M, Honda T, Tanizaki H, Otsuka A, Egawa G, Tokura Y, Waldmann H, Hori S, Cyster JG, Watanabe T, Miyachi Y, Kanagawa O, Kabashima K.
2010
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice.
J Clin Invest. 2010 Feb 22. pii: 40926. doi:10.1172/JCI40926. [Epub ahead of print]
Hale G, Rebello P, Al-Bakir I, Bolam E, Wiczling P, Jusko WJ, Vandemeulebroucke E, Keymeulen B, Mathieu C, Ziegler AG, Chatenoud L, Waldmann H.
2010
Pharmacokinetics and Antibody Responses to the CD3 Antibody Otelixizumab Used in the Treatment of Type 1 Diabetes.
J Clin Pharmacol. 2010 Feb 10. [Epub ahead of print]
Keymeulen B, Walter M, Mathieu C, Kaufman L, Gorus F, Hilbrands R, Vandemeulebroucke E, Van de Velde U, Crenier L, De Block C, Candon S, Waldmann H, Ziegler AG, Chatenoud L, Pipeleers D.
2010
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.
Diabetologia. 53(4):614-23. Epub 2010 Jan 14. PubMed PMID: 20225393.
Tong H, Miyazaki Y, Yamazaki M, Hara H, Waldmann H, Hori S, Yoshida H.
2010
Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice.
Immunol Lett. 2010 Feb 16;128(2):108-15. Epub 2010 Jan 12.
Mehta DS, Christmas RA, Waldmann H, Rosenzweig M.
2010
Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice.
Immunology. 2010 Jan 6. [Epub ahead of print]
Keymeulen B, Candon S, Fafi-Kremer S, Ziegler A, Leruez-Ville M, Mathieu C, Vandemeulebroucke E, Walter M, Crenier L, Thervet E, Legendre C, Pierard D, Hale G, Waldmann H, Bach JF, Seigneurin JM, Pipeleers D, Chatenoud L.
2010
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients.
Blood. 2010 Feb 11;115(6):1145-55. Epub 2009 Dec 9.
You S, Poulton L, Cobbold S, Liu CP, Rosenzweig M, Ringler D, Lee WH, Segovia B, Bach JF, Waldmann H, Chatenoud L.
2009
Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.
PLoS One. 2009 Nov 20;4(11):e7848.
Howie D, Nolan KF, Daley S, Butterfield E, Adams E, Garcia-Rueda H, Thompson C, Saunders NJ, Cobbold SP, Tone Y, Tone M, Waldmann H.
2009
MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation.
J Immunol. 2009 Oct 1;183(7):4197-204. Epub 2009 Sep 14.
Poulton LD, Nolan KF, Anastasaki C, Waldmann H, Patton EE.
2009
A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development.
Int J Dev Biol. 2009 Jul 1. [Epub ahead of print] PubMed PMID:19598108.
Tseng SY, Nishimoto KP, Silk KM, Majumdar AS, Dawes GN, Waldmann H, Fairchild PJ, Lebkowski JS, Reddy A.
2009
Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells.
Regen Med. 2009 Jul;4(4):513-26. PubMed PMID: 19580370.
Cobbold, SP., Adams, E., Farquhar, CA., Nolan, KF., Howie, D., Lui, KO., Fairchild, PJ., Mellow, AL., Ron, D., Waldmann, H.
2009
Infectious tolerance via the consumption of essential amino acids and mTOR signaling.
Proc Natl Acad Sci U S A. Epub 2009 June 30. doi:10.1073/pnas.0903919106.
Link to full version of the paper (Open Access).
Waldmann H, Cobbold S.
2009
Regulatory T cells: context matters
Immunity 30, May22; 2009: 613-615.
Clatworthy MR, Friend PJ, Calne RY, Rebello PR, Hale G, Waldmann H, Watson CJ.
2009
Alemtuzumab (CAMPATH-1H) for the treatment of acute rejection in kidney transplant recipients: long-term follow-up.
Transplantation. 2009 Apr15;87(7):1092-5.
Komatsu N, Mariotti-Ferrandiz ME, Wang Y, Malissen B, Waldmann H, Hori S.
2009
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity.
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1903-8. Epub 2009 Jan 27.
Lui KO, Waldmann H, Fairchild PJ.
2009
Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy.
Curr Stem Cell Res Ther. 2009 Jan;4(1):70-80.
CAMMS223 Trial Investigators, Coles AJ, Compston DA, Selmaj KW, Lake SL, Moran S, Margolin DH, Norris K, Tandon PK.
2008
Alemtuzumab vs. Interferon beta-1a in early multiple sclerosis.
N Engl J Med. 2008 Oct 23;359(17):1786-801.
Li Z, Benghiat FS, Charbonnier LM, Kubjak C, Rivas MN, Cobbold SP, Waldmann H, De Wilde V, Petein M, Schuind F, Goldman M, Le Moine A.
2008
CD8+ T-Cell Depletion and Rapamycin Synergize with Combined Coreceptor/Stimulation Blockade to Induce Robust Limb Allograft Tolerance in Mice.
Am J Transplant. 2008 Oct 6. [Epub ahead of print]
Daley SR, Cobbold SP, Waldmann H.
2008
Fc-disabled anti-mouse CD40L antibodies retain efficacy in promoting transplantation tolerance.
Am J Transplant. 2008 Nov;8(11):2265-71. Epub 2008 Sep 8.
Waldmann H, Adams E, Fairchild P, Cobbold S.
2008
Regulation and Privilege in Transplantation Tolerance.
J Clin Immunol. 2008 Sep 6. [Epub ahead of print]
Waldmann H.
2008
Tolerance can be infectious.
Nat Immunol. 2008 Sep;9(9):1001-3.
Waldmann H, Adams E, Cobbold S.
2008
Reprogramming the immune system: co-receptor blockade as a paradigm for harnessing tolerance mechanisms.
Immunol Rev. 2008 Jun;223:361-70.
Morgan AW, Hale G, Rebello PR, Richards SJ, Gooi HC, Waldmann H, Emery P, Isaacs JD.
2008
A pilot study of combination anti-cytokine and anti-lymphocyte biological therapy in rheumatoid arthritis.
QJM. 2008 Feb 19; [Epub ahead of print]
Lorenzi AR, Clarke AM, Wooldridge T, Waldmann H, Hale G, Symmons D, Hazleman BL, Isaacs JD.
2008
Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: twelve-year outcomes.
Arthritis Rheum. 2008 Feb;58(2):370-5.
Zhou Z, Tone Y, Song X, Furuuchi K, Lear JD, Waldmann H, Tone M, Greene MI, Murali R.
2008
Structural basis for ligand-mediated mouse GITR activation.
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):641-5. Epub 2008 Jan 4.
Waldmann H.
2008
Special regulatory T cell review: The suppression problem!
Immunology. 2008 Jan;123(1):11-2.
Robertson NJ, Brook FA, Gardner RL, Cobbold SP, Waldmann H, Fairchild PJ.
2007
Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance.
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20920-5. Epub 2007 Dec 18.
Robertson NJ, Fairchild PJ, Waldmann H.
2007
Ectopic transplantation of tissues under the kidney capsule.
Methods Mol Biol. 2007;380:347-53.
Nolan KF, Cobbold SP, Waldmann H.
2007
SAGE analysis of cell types involved in tolerance induction.
Methods Mol Biol. 2007;380:225-51.
Fairchild PJ, Nolan KF, Waldmann H.
2007
Genetic modification of dendritic cells through the directed differentiation of embryonic stem cells.
Methods Mol Biol. 2007;380:59-72.
Daley SR, Ma J, Adams E, Cobbold SP, Waldmann H.
2007
A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts.
J Immunol. 2007 Sep 15;179(6):3648-54.
Fairchild PJ, Robertson NJ, Minger SL, Waldmann H.
2007
Embryonic stem cells: protecting pluripotency from alloreactivity.
Curr Opin Immunol. 2007 Oct;19(5):596-602. Epub 2007 Aug 20. Review.
Fairchild PJ, Robertson NJ, Cartland S, Nolan KF, Waldmann H.
2005
Cell replacement therapy and the evasion of destructive immunity.
Stem Cell Rev. 2005;1(2):159-67. Review.
Yates SF, Paterson AM, Nolan KF, Cobbold SP, Saunders NJ, Waldmann H, Fairchild PJ.
2007
Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation.
J Immunol. 179(2):967-76.
Tuyaerts S, Van Meirvenne S, Bonehill A, Heirman C, Corthals J, Waldmann H, Breckpot K, Thielemans K, Aerts JL.
2007
Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.
J Leukoc Biol. 82(1):93-105.
Cobbold SP, Adams E, Graca L, Daley S, Yates S, Paterson A, Robertson NJ, Nolan KF, Fairchild PJ, Waldmann H.
2006
Immune privilege induced by regulatory T cells in transplantation tolerance.
Immunol Rev. 213:239-55.
Waldmann H.
2006
Immunology: protection and privilege.
Nature. 442(7106):987-8.
Waldmann H, Adams E, Fairchild P, Cobbold S.
2006
Infectious tolerance and the long-term acceptance of transplanted tissue.
Immunol Rev. 212:301-13.
Glatting G, Muller M, Koop B, Hohl K, Friesen C, Neumaier B, Berrie E, Bird P, Hale G, Blumstein NM, Waldmann H, Bunjes D, Reske SN.
2006
Anti-CD45 monoclonal antibody YAML568: A promising radioimmunoconjugate for targeted therapy of acute leukemia.
J Nucl Med. 47(8):1335-41.
Graca L, Waldmann H.
2006
Reprogramming the immune system using antibodies.
Methods Mol Biol. 333:247-68.
van de Linde P, Tysma OM, Medema JP, Hale G, Waldmann H, Roelen DL, Roep BO.
2006
Mechanisms of antibody immunotherapy on clonal islet reactive T cells.
Hum Immunol. 67(4-5):264-73.
Graca L, Daley S, Fairchild PJ, Cobbold SP, Waldmann H.
2006
Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning.
BMC Immunol. Apr 25;7:9.
Neujahr DC, Chen C, Huang X, Markmann JF, Cobbold S, Waldmann H, Sayegh MH, Hancock WW, Turka LA.
2006
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it.
J Immunol. 176(8):4632-9.
Waldmann H, Chen TC, Graca L, Adams E, Daley S, Cobbold S, Fairchild PJ.
2006
Regulatory T cells in transplantation.
Semin Immunol. 18(2):111-9.
Paterson AM, Yates SF, Nolan KF, Waldmann H.
2005
The new immunosuppression: intervention at the dendritic cell-T-cell interface.
Curr Drug Targets Immune Endocr Metabol Disord. 5(4):397-411. Review.
Hisaeda H, Hamano S, Mitoma-Obata C, Tetsutani K, Imai T, Waldmann H, Himeno K, Yasutomo K.
2005
Resistance of regulatory T cells to glucocorticoid-viduced TNFR family-related protein (GITR) during Plasmodium yoelii infection.
Eur J Immunol. 35(12):3516-24.
Cox AL, Thompson SA, Jones JL, Robertson VH, Hale G, Waldmann H, Compston DA, Coles AJ.
2005
Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis.
Eur J Immunol.35(11):3332-42.
Stebbings R, Berry N, Waldmann H, Bird P, Hale G, Stott J, North D, Hull R, Hall J, Lines J, Brown S, D'Arcy N, Davis L, Elsley W, Edwards C, Ferguson D, Allen J, Almond N.
2005
CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus.
J Virol. 79(19):12264-72.
Waldmann H, Hale G.
2005
CAMPATH: from concept to clinic.
Philos Trans R Soc Lond B Biol Sci. 360(1461):1707-11.
Suvas S, Kim B, Sarangi PP, Tone M, Waldmann H, Rouse BT.
2005
In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology.
J Virol. 2005 Sep;79(18):11935-42.
Novitzky N, Thomas V, Hale G, Waldmann H.
2005
Myeloablative conditioning is well tolerated by older patients receiving T-cell-depleted grafts.
Bone Marrow Transplant. Aug 22; [Epub ahead of print]
Coles AJ, Cox A, Le Page E, Jones J, Trip SA, Deans J, Seaman S, Miller DH, Hale G, Waldmann H, Compston DA.
2005
The window of therapeutic opportunity in multiple sclerosis Evidence from monoclonal antibody therapy.
J Neurol. 253:98-108.
Waldmann H, Graca L, Adams E, Fairchild P, Cobbold S.
2005
Regulatory T cells in transplantation tolerance.
Curr Top Microbiol Immunol. 293:249-64.
Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S, Schandene L, Crenier L, De Block C, Seigneurin JM, De Pauw P, Pierard D, Weets I, Rebello P, Bird P, Berrie E, Frewin M, Waldmann H, Bach JF, Pipeleers D, Chatenoud L.
2005
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
N Engl J Med. 352(25):2598-608.
Waldmann H.
2005
Contact between good friends: what limiting dilution analysis taught us.
Scand J Immunol. 62 Suppl 1:30-2.
Peggs KS, Hunter A, Chopra R, Parker A, Mahendra P, Milligan D, Craddock C, Pettengell R, Dogan A, Thomson KJ, Morris EC, Hale G, Waldmann H, Goldstone AH, Linch DC, Mackinnon S.
2005
Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation.
Lancet. 365(9475):1934-41.
Watson CJ, Bradley JA, Friend PJ, Firth J, Taylor CJ, Bradley JR, Smith KG, Thiru S, Jamieson NV, Hale G, Waldmann H, Calne R.
2005
Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation--efficacy and safety at five years.
Am J Transplant. 5(6):1347-53.
You S, Belghith M, Cobbold S, Alyanakian MA, Gouarin C, Barriot S, Garcia C, Waldmann H, Bach JF, Chatenoud L.
2005
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.
Diabetes. 54(5):1415-22.
Benghiat FS, Graca L, Braun MY, Detienne S, Moore F, Buonocore S, Flamand V, Waldmann H, Goldman M, Le Moine A.
2005
Critical Influence of Natural Regulatory CD25+ T Cells on the Fate of Allografts in the Absence of Immunosuppression.
Transplantation. 79(6):648-654.
Waldmann H.
2005
Thomas' hematopoietic cell transplantation.
Bone Marrow Transplant. 35(6):633.
Graca L, Chen TC, Moine AL, Cobbold SP, Howie D, Waldmann H.
2005
Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells.
Trends Immunol. 26(3): 130-5.
Yee CS, Yao Y, Xu Q, McCarthy B, Sun-Lin D, Tone M, Waldmann H, Chang CH.
2005
Enhanced Production of IL-10 by Dendritic Cells Deficient in CIITA.
J Immunol. 174(3):1222-9.
Fairchild PJ, Nolan KF, Cartland S, Waldmann H.
2005
Embryonic stem cells: a novel source of dendritic cells for clinical applications.
Int Immunopharmacol. 5(1):13-21.
Gupta V, Ball SE, Yi QL, Sage D, McCann SR, Lawler M, Ortin M, Freires M, Hale G, Waldmann H, Gordon-Smith EC, Marsh JC.
2004
Favorable effect on acute and chronic graft-versus-host disease with cyclophosphamide and in vivo anti-CD52 monoclonal antibodies for marrow transplantation from HLA-identical sibling donors for acquired aplastic anemia.
Biol Blood Marrow Transplant 10(12): 867-76.
Novitzky N, Thomas V, Stubbings H, Hale G, Waldmann H.
2004
Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia.
Cytotherapy 6(5): 450-6.
Winsor-Hines D, Merrill C, O'Mahony M, Rao PE, Cobbold SP, Waldmann H, Ringler DJ, Ponath PD
2004
Induction of Immunological Tolerance/Hyporesponsiveness in Baboons with a Nondepleting CD4 Antibody
J. Immunol. 173: 4715-4723. Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Mellor AL, Chandler P, Baban B, Hansen AM, Marshall B, Pihkala J, Waldmann H, Cobbold S, Adams E, Munn DH.
2004
Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase.
Int Immunol. Sep 6 [Epub ahead of print]
Fairchild PJ, Cartland S, Nolan KF, Waldmann H.
2004
Embryonic stem cells and the challenge of transplantation tolerance.
Trends Immunol. 25(9):465-70.
Chakrabarti S, Hale G, Waldmann H.
2004
Alemtuzumab (Campath-1H) in allogeneic stem cell transplantation: where do we go from here?
Transplant Proc.36(5):1225-7.
Waldmann, H., Cobbold, S.
2004
Viewpoint: Exploiting tolerance processes in transplantation
Science 305: 209-212.
Abstract Full Text
Graca L, Le Moine A, Lin CY, Fairchild PJ, Cobbold SP, Waldmann H.
2004
Donor-specific transplantation tolerance: The paradoxical behavior of CD4+CD25+ T cells.
Proc Natl Acad Sci U S A. 101(27):10122-6.
Novitzky N, Thomas V, Hale G, Waldmann H.
2004
Campath-1 Abs 'in the bag' for hematological malignancies: the Cape Town experience.
Cytotherapy. 6(2):172-81.
Chen, T-C., Waldmann, H., Fairchild, PJ.
2004
Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen, Dby.
J. Clin. Invest. 113: 1734-1742.
Abstract | Article | PDF
Murphy CC, Greiner K, Plskova J, Duncan L, Frost A, Isaacs JD, Rebello P, Waldmann H, Hale G, Forrester JV, Dick AD.
2004
Neutralizing tumor necrosis factor activity leads to remission in patients with refractory noninfectious posterior uveitis.
Arch Ophthalmol. Jun;122(6):845-51.
Hale G, Rebello P, Brettman L, Fegan C, Kennedy B, Kimby E, Leach M, Lundin J, Mellstedt H, Moreton P, Rawstron A, Waldmann H, Osterborg A, Hillmen P.
2004
Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration.
Blood. 2004 Apr 15 [Epub ahead of print]
Cobbold, SP., Castejon, R., Adams, E., Zelenika, D., Graca, L., Humm, S., Waldmann, H.
2004
Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.
J. Immunol. 172: 6003-6010.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Chen, T-C., Cobbold, SP., Fairchild, PJ., Waldmann, H.
2004
Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen.
J. Immunol. 172: 5900-5907.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Waldmann, H., Graca, L., Cobbold, SP., Adams, E., Tone, M., Tone, Y.
2004
Regulatory T cells and organ transplantation
Seminars in Immunology 16(2): 119-126.
Avivi I, Chakrabarti S, Milligan DW, Waldmann H, Hale G, Osman H, Ward KN, Fegan CD, Yong K, Goldstone AH, Linch DC, Mackinnon S.
2004
Incidence and outcome of adenovirus disease in transplant recipients after reduced-intensity conditioning with alemtuzumab.
Biol Blood Marrow Transplant. 10(3):186-94.
Nolan KF, Strong V, Soler D, Fairchild PJ, Cobbold SP, Croxton R, Gonzalo JA, Rubio A, Wells M, Waldmann H.
2004
IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals.
J Immunol. 172(4):2201-9.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Lockwood, C. M., G. Hale, et al.
2003
Remission induction in Behcet's disease following lymphocyte depletion by the anti-CD52 antibody CAMPATH 1-H.
Rheumatology (Oxford) 42(12): 1539-44.
Tone, M., Tone, Y., Adams, E., Yates, SF., Frewin, M., Cobbold, SP., Waldmann, H.
2003
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells
Proc. Natl. Acad. Sci. USA. 100 (25): 15059-15064.
published online before print.
Fairchild, PJ., Nolan, KF., Waldmann, H.
2003
Probing dendritic cell function by guiding the differentiation of embryonic stem cells.
Methods Enzymol. 365: 169-186.
Graca, L., LeMoine, A., Cobbold, SP., Waldmann, H.
2003
Antibody-induced transplantation tolerance: the role of dominant regulation.
Immunol. Research, 28(3): 181-191.
Cobbold, SP., Nolan, K., Graca, L., Castejon, R., LeMoine, A., Frewin, M., Humm, S., Adams, E., Thompson, S., Zelenika, D., Paterson, A., Yates, S., Fairchild, PJ., Waldmann, H.
2003
Regulatory T cells and Dendritic cells in Transplantation Tolerance: molecular markers and mechanisms.
Immunol. Reviews 196: 109-124.
Chakrabarti S, Milligan DW, Pillay D, Mackinnon S, Holder K, Kaur N, McDonald D, Fegan CD, Waldmann H, Hale G, Rickinson A, Steven N.
2003
Reconstitution of the Epstein-Barr virus-specific cytotoxic T-lymphocyte response following T-cell-depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation.
Blood 102(3): 839-42.
Waldmann, H.
2003
The new immunosuppression: just kill the T cell
Nature Medicine 9: 1259-1260.
D'Sa, S., Peggs, K., Pizzey, A., Verfuerth, S., Thuraisundaram, D., Watts, M., Hale, G., Waldmann, H., Goldstone, A., McKinnon, S., Yong, K.
2003
T- and B-cell immune reconstitution and clinical outcome in patients with multiple myeloma receiving T-cell-depleted, reduced-intensity allogeneic stem cell transplantation with alemtuzumab-containing conditioning regimen followed by escalated donor lymphocyte infusions.
Br. J. Haematol. 123(2): 309-322.
Waldmann, H.
2003
Transplantation. Regulating the rejection process: the search for new targets to minimise immunosuppressive therapy.
Curr. Opin. Immunol. 15(5): 477-478.
Graca, L., LeMoine, A., Cobbold SP., Waldmann, H.
2003
Dominant transplantation tolerance.
Curr. Opin. Immunol., 15(5): 499-506.
Waldmann, H.
2003
The new immunosuppression
Current Opinion in Chemical Biology 7: 476-4809.
Cobbold, SP., Adams, E., Graca, L., Waldmann, H.
2003
Serial analysis of gene expression provides new insights into regulatory T cells.
Seminars in Immunology 15(4): 209-214.
Peggs, KS., MacKinnon, S., Williams, CD., D'Sa, S., Thuraisundaram, D., Kyriakou, C., Morris, EC., Hale, G., Waldmann, H. Linch, DC., Goldstone, AH., Yong, K.
2003
Reduced intensity transplantation with in vivo T-cell depletion and adjuvant dose-escalating donor lympjhocyte infusions for chemotherapy-sensitive myeloma: Limited efficacy of graft-versus-tumor activity.
Biol. Blood Marrow Transplant. 9(4): 257-265.
Fairchild, PJ., Nolan, KF., Cartland, S., Graca, L., Waldmann, H.
2003
Stable lines of genetically modified dendritic cells from mouse embryonic stem cells.
Transplantation 76(3): 606-608.
Chakrabarti S, MacDonald D, Hale G, Holder K, Turner V, Czarnecka H, Thompson J, Fegan C, Waldmann H, Milligan DW.
2003
T-cell depletion with Campath-1H 'in the bag' for matched related allogeneic peripheral blood stem cell transplantation is associated with reduced graft-versus-host disease, rapid immune constitution and improved survival.
Br J Haematol. 121(1):109-18.
Cobbold SP, Graca L, Lin C-Y, Adams E, Waldmann H.
2003
Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance.
Transplant International 16:66-75.
Novitzky N, Davison GM, Hale G, Waldmann H.
2002
Immune reconstitution at 6 months following T-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome.
Transplantation. 74(11): 1551-9.
Hale G, Slavin S, Goldman JM, Mackinnon S, Giralt S, Waldmann H.
2002
Alemtuzumab (Campath-1H) for treatment of lymphoid malignancies in the age of nonmyeloablative conditioning?
Bone Marrow Transplant. 30(12): 797-804.
Chakrabarti S, Avivi I, Mackinnon S, Ward K, Kottaridis PD, Osman H, Waldmann H, Hale G, Fegan CD, Yong K, Goldstone AH, Linch DC, Milligan DW.
2002
Respiratory virus infections in transplant recipients after reduced-intensity conditioning with Campath-1H: high incidence but low mortality.
Br J Haematol. 119(4): 1125-32.
Symons JA, Adams E, Tscharke DC, Reading PC, Waldmann H, Smith GL.
2002
The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model.
J. Gen. Virol. 83: 2833-2844.
Lin, C-Y., Graca, L., Cobbold, SP., Waldmann, H.
2002
Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.
Nature Immunology 3(12): 1208-1213.
Published online here.
Waldmann H.
2002
Transplantation - caught in the crossfire! (News and Views)
Nature Immunology 3: 803-804.
Chakrabarti S, Mackinnon S, Chopra R, Kottaridis PD, Peggs K, O'Gorman P, Chakraverty R, Marshall T, Osman H, Mahendra P, Craddock C, Waldmann H, Hale G, Fegan CD, Yong K, Goldstone AH, Linch DC, Milligan DW.
2002
High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution.
Blood. 99(12): 4357-63.
Waldmann H.
2002
Reprogramming the immune system.
Immunol Rev. 185(1): 227-35.
Lundin J, Kimby E, Bjorkholm M, Broliden PA, Celsing F, Hjalmar V, Mollgard L, Rebello P, Hale G, Waldmann H, Mellstedt H, Osterborg A.
2002
Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL).
Blood. 100(3): 768-73.
Waldmann H.
2002
A personal history of the CAMPATH-1H antibody.
Med Oncol. 2002;19 Suppl:S3-9.
Graca, L., Cobbold, SP., and Waldmann, H.
2002
Identification of regulatory T cells in tolerated allografts.
J. Exp. Med. 195(12): 1641-1646.
Graca, L., Thompson, S., Lin, C-Y., Adams, E., Cobbold, S., Waldmann H.
2002
Both CD4+CD25+ and CD4+CD25- regulatory cells mediate dominant transplantation tolerance.
J. Immunol. 168(11): 5558-5565.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Tone M, Tone Y, Babik JM, Lin CY, Waldmann H.
2002
The Role of Sp1 and NF-kB in Regulating CD40 Gene Expression.
J Biol Chem. 277(11): 8890-7.
Zelenika, D., Adams, E. Humm, S., Graca, L., Thompson, S., Cobbold, S*., Waldmann, H*.
*joint senior authors
2002
Regulatory T cells over-express a subset of Th2 gene transcripts
J. Immunol. 168: 1069-1079.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Chakraverty R, Peggs K, Chopra R, Milligan DW, Kottaridis PD, Verfuerth S, Geary J, Thuraisundaram D, Branson K, Chakrabarti S, Mahendra P, Craddock C, Parker A, Hunter A, Hale G, Waldmann H, Williams CD, Yong K, Linch DC, Goldstone AH, Mackinnon S.
2002
Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen.
Blood. 99(3): 1071-8.
Hale G, Cobbold S, Novitzky N, Bunjes D, Willemze R, Prentice HG, Milligan D, MacKinnon S, Waldmann H.
2001
CAMPATH-1 antibodies in stem-cell transplantation.
Cytotherapy. 3(3): 145-64.
Waldmann, H.
2001
Tolerance induction with CD4 monoclonal antibodies. in
Autoimmunity and Emerging Diseases.
Steinman L., (ed.)
Center for Study of Emerging Diseases CSED: Ch. 20: 240-246.
Kottaridis PD, Milligan DW, Chopra R, Chakraverty RK, Chakrabarti S, Robinson S, Peggs K, Verfuerth S, Pettengell R, Marsh JC, Schey S, Mahendra P, Morgan GJ, Hale G, Waldmann H, De Elvira MC, Williams CD, Devereux S, Linch DC, Goldstone AH, MacKinnon S.
2001
In vivo CAMPATH-1H prevents GvHD following nonmyeloablative stem-cell transplantation.
Cytotherapy. 3(3): 197-201.
Chakraverty R, Robinson S, Peggs K, Kottaridis PD, Watts MJ, Ings SJ, Hale G, Waldmann H, Linch DC, Goldstone AH, Mackinnon S.
2001
Excessive T cell depletion of peripheral blood stem cells has an adverse effect upon outcome following allogeneic stem cell transplantation.
Bone Marrow Transplant. 28(9): 827-34.
Willis F, Marsh JC, Bevan DH, Killick SB, Lucas G, Griffiths R, Ouwehand W, Hale G, Waldmann H, Gordon-Smith EC.
2001
The effect of treatment with Campath-1H in patients with autoimmune cytopenias.
Br J Haematol. 114(4): 891-8.
Waldmann, H., Cobbold, SP.
2001
Approaching tolerance in transplantation.
Int. Arch. Allergy Immunol. 126: 11-22.
Waldmann, H.
2001
Therapeutic approaches for transplantation.
Current Opinion in Immunology 13: 606-610.
Isaacs, JD., Greer, S., Sharma, S., Symmons, D., Smith, M., Johnston, J., Waldmann, H., Hale, G., Hazleman, BL.
2001
Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia.
Arthritis and Rheumatism 44: 1998-2008.
Zelenika, D., Adams, E., Humm, S., Lin, C-Y., Waldmann, H. and Cobbold, SP.
2001
The role of CD4+ T cell subsets in determining transplantation rejection or tolerance.
Immunol. Rev. 182: 164-179.
Taylor PA., Lees CJ., Waldmann, H., Noelle, RJ., Blazar, BR.
2001
Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions.
Blood 98: 467-74.
Barge, RMY., Brouwer, RE., Beersma, MFC., Starrenburg, CWJ., Zwinderman, AH., Hale, G., Waldmann, H., den Ottolander, GJ., Falkenburg, JHF., Willemze, R., Fibbe, WE.
2001
Comparison of allogeneic T cell-depleted peripheral blood stem cell and bone marrow transplantation: effect of stem cell source on short- and long-term outcome.
Bone Marrow Transplantation 27: 1053-1058.
Waldmann, H., Cobbold, SP., Fairchild, P. and Adams, E.
2001
Therapeutic aspects of tolerance.
Current Opinions in Pharmacology 1: 392-397.
Graca, L. and Waldmann, H.
2001
Dominant transplantation tolerance.
Graft 4: 174-179.
Waldmann, H. and Cobbold, S.
2001
Regulating the immune response to transplants: a role for CD4+ regulatory cells?
Review
Immunity 14: 399-406.
Waldmann, H., Hale, G., Cobbold, S.
2001
Appropriate targets for monoclonal antibodies in the induction of transplantation tolerance.
Phil. Trans. R. Soc. Lond. B, 356: 1-5.
Tone, M., Tone, Y., Fairchild, PJ., Wykes, M., Waldmann, H.
2001
Regulation of CD40 function by its isoforms generated through alternative splicing.
Proc. Natl. Acad. Sci. (USA) 98(4): 1751-1756.
Thiru, S., Waldmann, H. (Editors)
2001
Pathology and Immunology of Transplantation and Rejection
Pub: Blackwell Science, Oxford.
Waldmann, H., Cobbold, S., and Hale, G.
2001
Graft versus host disease: its control and prospects for allogeneic bone marrow transplantation.
in Pathology and Immunology of Transplantation and Rejection
Thiru, S., Waldmann, H. (Editors)
Pub: Blackwell Science, Oxford.
pp 438-445.
Hale, G., Waldmann, H.
2000
From laboratory to clinic: the story of CAMPATH-1
in Molecular Medicine Vol 40: Diagnostic and Therapeutic Antibodies
George, AJT., Urch, CE., Eds.
Pub: Humana Press Inc. Totowa, NJ.
pp 243-266.
Fairchild, PJ., Brook, FA., Gardner, RL., Graca, L., Strong, V., Tone, Y., Tone, M., Nolan, KF., Waldmann, H.
2000
Directed differentiation of dendritic cells from mouse embryonic stem cells.
Current Biology 10(3): 1515-18.
Graca, L., Honey, K., Adams, E., Cobbold, SP., Waldmann, H.
2000
Cutting Edge: Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.
J. Immunol. 165: 4783-4786.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Kottaridis PD, Milligan DW, Chopra R, Chakraverty RK, Chakrabarti S, Robinson S, Peggs K, Verfuerth S, Pettengell R, Marsh JC, Schey S, Mahendra P, Morgan GJ, Hale G, Waldmann H, de Elvira MC, Williams CD, Devereux S, Linch DC, Goldstone AH, Mackinnon S.
2000
In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation.
Blood. 96(7):2419-25.
Hale G, Jacobs P, Wood L, Fibbe WE, Barge R, Novitzky N, Toit C, Abrahams L, Thomas V, Bunjes D, Duncker C, Wiesneth M, Selleslag D, Hidajat M, Starobinski M, Bird P, Waldmann H.
2000
CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells.
Bone Marrow Transplant. 26(1):69-76.
Cull GM, Haynes AP, Byrne JL, Carter GI, Miflin G, Rebello P, Hale G, Waldmann H, Russell NH.
2000
Preliminary experience of allogeneic stem cell transplantation for lymphoproliferative disorders using BEAM-CAMPATH conditioning: an effective regimen with low procedure-related toxicity.
Br J Haematol. 108(4):754-60.
Calne R, Moffatt SD, Friend PJ, Jamieson NV, Bradley JA, Hale G, Firth J, Bradley J, Smith KG, Waldmann H.
2000
Prope tolerance with induction using Campath 1H and low-dose cyclosporin monotherapy in 31 cadaveric renal allograft recipients.
Nippon Geka Gakkai Zasshi. 101(3):301-6.
Davison, GM., Novitzky, N., Kline, A., Thomas, V., Abrahams, L., Hale, G., and Waldmann, H.
2000
Immune reconstitution after allogeneic bone marrow transplantation depleted of T cells.
Transplantation 69: 1341-1347.
Waldmann, H.
2000
Transplantation (Editorial Overview).
Current Opinion in Immunology 12: 509-510.
Fairchild PJ., and Waldmann, H.
2000
Dendritic cells and prospects for transplantation tolerance.
Current Opinion in Immunology 12: 528-535.
Fairchild PJ., and Waldmann, H.
2000
Extrathymic signals regulate the onset of T cell repertoire selection.
Eur. J. Immunol. 30(7): 1948-56.
Waldmann, H.
2000
Prospects for the application of antibodies in medicine.
From Methods in Molecular Medicine Vol 40: Diagnostic and therapeutic antibodies.
pp 63-72.
George AJT., and Urch, CE. (Eds) Humana Press Inc., Totowa NJ.
Powell MJ, Thompson SA, Tone Y, Waldmann H, Tone M.
2000
Posttranscriptional Regulation of IL-10 Gene Expression Through Sequences in the 3'-Untranslated Region.
J Immunol. 165(1):292-296.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Tone M, Powell MJ, Tone Y, Thompson SA, Waldmann H.
2000
IL-10 Gene Expression Is Controlled by the Transcription Factors Sp1 and Sp3.
J Immunol. 165(1):286-291.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Williams, RJ., Clarke, E., Blair, A., Evely, R., Hale, G., Waldmann, H., Brookes, S., Pamphilon, DH.
2000
Impact on T cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PBSC collections: comparison with CAMPATH-1M and CAMPATH-1G.
Cytotherapy 2(1): 5-14.
Waldmann, H., and Cobbold, S.
2000
T-cell regulation and transplantation tolerance.
Current Opinions in Organ Transplantation 5: 83-89.
Honey, K., Bemelman, F., Cobbold, S.P., and Waldmann, H.
2000
High dose bone marrow transplantation induces deletion of antigen-specific T cells in a Fas independent manner.
Transplantation, 69(8): 1676-1682.
Honey, K., Cobbold, S.P., and Waldmann, H.
2000
Dominant tolerance and linked suppression induced by therapeutic antibodies do not depend on Fas-FasL interactions.
Transplantation, 69(8):1683-1689.
Byrne JL, Stainer C, Cull G, Haynes AP, Bessell EM, Hale G, Waldmann H, Russell NH.
2000
The effect of the serotherapy regimen used and the marrow cell dose received on rejection, graft versus host disease and outcome following unrelated donor bone marrow transplantation for leukaemia.
Bone Marrow Transplant. 25(4): 411-7.
Dick AD, Meyer P, James T, Forrester JV, Hale G, Waldmann H, Isaacs JD.
2000
Campath-1H therapy in refractory ocular inflammatory disease.
Br J Ophthalmol. 84:107-109
Wise, M., Cobbold, S. & Waldmann, H.
2000
Tolerance induction with CD4 monoclonal antibodies: a role for minors in linked suppression.
In: Minor Histocopatibility Antigens (Eds Roopenian, D.C. & Simpson, E.) Landis BioScience, Austin, Texas, pp141-147.
James, LC., Hale, G., Waldmann, H., and Bloomer, AC.
1999
1.9A structure of the therapeutic antibody CAMPATH-1H Fab in complex with a synthetic peptide antigen
J. Mol. Biol. 289: 293-301.
Friend PJ, Hale G, Chatenoud L, Rebello P, Bradley J, Thiru S, Phillips JM, Waldmann H.
1999
Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection.
Transplantation. 68(11):1632-7
Calne R, Moffatt SD, Friend PJ, Jamieson NV, Bradley JA, Hale G, Firth J, Bradley J, Smith KG, Waldmann H
1999
Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients.
Transplantation 68(10):1613-6
Rebello PR, Hale G, Friend PJ, Cobbold SP, Waldmann H.
1999
Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection.
Transplantation 68(9):1417-20
Coles AJ, Wing M, Smith S, Coraddu F, Greer S, Taylor C, Weetman A, Hale G, Chatterjee VK, Waldmann H, Compston A
1999
Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis.
Lancet 354(9191):1691-5
Waldmann H
1999
Transplantation tolerance-where do we stand?
Nat Med 5(11):1245-8.
Honey K, Cobbold SP, Waldmann H
1999
CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression.
J Immunol 163(9):4805-10.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Lockwood CM, Elliott JD, Brettman L, Hale G, Rebello P, Frewin M, Ringler D, Merrill C, Waldmann H
1999
Anti-adhesion molecule therapy as an interventional strategy.
Clin Immunol 93(2):93-106.
Tone M, Nolan KF, Walsh LA, Tone Y, Thompson SA, Waldmann H
1999
Structure and chromosomal location of mouse and human CD52 genes.
Biochim Biophys Acta 1446(3):334-40.
Conaghan PG, Sommer S, McGonagle D, Veale D, Waldmann H, Hale G, Goodfield M, Emery P, Isaacs J
1999
The relationship between pityriasis rubra pilaris and inflammatory arthritis: case report and response of the arthritis to anti-tumor necrosis factor immunotherapy.
Arthritis Rheum 42(9):1998-2001.
Milstein C, Waldmann H
1999
Optimism after much pessimism: what next?
Curr Opin Immunol 11(5):589-91
Green A, Clarke E, Hunt L, Canterbury A, Lankester A, Hale G, Waldmann H, Goodman S, Cornish JM, Marks DI, Steward CG, Oakhill A, Pamphilon DH
1999
Children with acute lymphoblastic leukemia who receive T-cell-depleted HLA mismatched marrow allografts from unrelated donors have an increased incidence of primary graft failure but a similar overall transplant outcome.
Blood 94(7):2236-46
Coles AJ, Wing MG, Molyneux P, Paolillo A, Davie CM, Hale G, Miller D, Waldmann H, Compston A
1999
Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis.
Ann Neurol 46(3):296-304
Honey K, Cobbold SP, Waldmann H
1999
Dominant regulation: a common mechanism of monoclonal antibody induced tolerance?
Immunol Res 20(1):1-14
Naparstek E, Delukina M, Or R, Nagler A, Kapelushnik J, Varadi G, Strauss N, Cividalli G, Aker M, Brautbar C, Waldmann H, Hale G, Slavin S
1999
Engraftment of marrow allografts treated with Campath-1 monoclonal antibodies.
Exp Hematol 27(7):1210-8
Parry-Jones N, Haque T, Ismail M, Jones L, Hale G, Waldmann H, Gordon-Smith EC, Crawford DH, Marsh JC
1999
Epstein-Barr virus (EBV) associated B-cell lymphoproliferative disease following HLA identical sibling marrow transplantation for aplastic anaemia in a patient with an EBV seronegative donor.
Transplantation 67(10):1373-5
Novitzky N, Thomas V, Hale G, Waldmann H
1999
Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect.
Transplantation 67(4):620-6
Hudde, T., Rayner, S.A., Weber, M.,Isaacs, J.D., Waldmann, H., Larkin, D.F.P., and George, A.J.T.
(1999)
Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium.
Gene Therapy 6: 939-943.
Babik, J.M., Adams, E., Tone, Y., Fairchild, P.J., Tone, M., and Waldmann, H.
(1999)
Expression of murine IL-12 is regulated by translational control of the p35 subunit
J. Immunol. 162: 4069-4078.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Gilliland, L.K., Walsh, L.A., Frewin, M.R., Wise, M.P., Tone, M., Hale, G., and Waldmann, H.
(1999)
Elimination of the immunogenicity of therapeutic antibodies.
J. Immunol. 162: 3663-3671.
Abstract | Article | PDF
(Article and PDF formats only available to JI subscribers)
Lefkovits, I., and Waldmann, H.
1999
Limiting dilution analysis of cells of the imune system.
Oxford University Press, Oxford.
Tone, M., Diamond. L.E., Wlash, L.A., Thompson, S.A.J., Shanahan, E.M., Logan, J.S., and Waldmann, H.
(1999)
High level transcription of the complement regulatory protein CD59 requires an enhancer located in intron 1.
J. Biol. Chem. 274: 710-716.
Abstract | Article | PDF
(Article and PDF formats only available to JBC subscribers)
Waldmann, H., Gilliland, L.K., Cobbold, S.P., and Hale, G.
1999
Immunotherapy
in Fundamental Immunology, Fourth Edition., Ed. Paul, W.E.,
Lipincott-Raven Publishers, Philadelphia, Chapter 45: 1511-1533.
Wise, M., Zelenika, D., Bemelman, F., Latinne, D., Bazin, H., Cobbold, S., and Waldmann, H.
1999
CD4 T cells can reject major histocompatibility complex class I incompatible skin grafts.
Eur. J. Immunol. 29: 156-167.
Elliott JD, Lockwood CM, Hale G, Waldmann H
1998
Semi-specific immuno-absorption and monoclonal antibody therapy in ANCA positive vasculitis: experience in four cases.
Autoimmunity 28(3):163-71.
Lockwood, C.M., Thiru, S., Stewart, S., Drummond, C., Elliott, J., Hale, G., Flower, C.D., Wraight, E.P., and Waldmann, H.
(1998)
Refractory Wegener's granulomatosis: a model for shorter term therapy of autoimmune diseases.
Journal of the Royal College of Physicians 32: 473.
Cheetham, G.M.T., Hale, G., Waldmann, H. and Bloomer, A.C.
(1998)
Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart.
J. Mol. Biol. 284: 85-99.
Hale, G., Zhang, M-J., Bunjes, D., Prentice, HG., Spence, D., Horowitz, M., Barrett, J., and Waldmann, H.
(1998)
Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection.
Blood, 92(12): 4581-4590.
Nolan, K., Greaves, D.R. & Waldmann, H.
(1998)
The human interleukin 18 gene IL 18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.
Genomics, 51, 161-163.
Waldmann, H.
(1998)
The applications of antibodies in medicine.
In: Diagnostic and Therapeutic Antibodies (Ed. George A.J.T.) Molecular Medicine Series, Humana Press.
Isaacs, J. D., Greenwood, J. & Waldmann, H.
(1998)
Therapy with monoclonal antibodies. II. The contribution of Fc-gamma receptor binding and the influence of ChI and CH3 domains on in vivo effector function.
J. Immunol. 161, 3862-3869
Isaacs, J.D. & Waldmann, H.
(1998)
Regaining self-control. (editorial letter)
British Journal of Rheumatology 37, 926-929
Wise, M.P., Bemelman, F., Cobbold, S.P., and Waldmann, H.
1998
Linked suppression can operate through indirect recognition.
J. Immunol. 161: 5813-5816.
Clarke, E., Potter, M.N., Hale, G., Waldmann, H., Lankester, A., Cornish, J.M., Steward, C.G., Marks, D.I., Oakhill, A. and Pamphilon, D.H.
1998
Double T cell depletion of bone marrow using sequential positive and negative cell immunoaffinity or CD34+ cell selection followed by CAMPATH-1M: effect on CD34+ cells and progenitor cell recoveries.
Bone Marrow Transplant. 22: 117-124.
Dick, A.D., Duncan, L., Hale, G., Waldmann, H., and Isaacs, J.
1998
Neutralizing TNF-alpha activity modulates T-cell phenotype and function in experimental autoimmune uveoretinitis.
Cell. Immunol. 185: 101-113.
Zelenika,D., Adams, E., Mellor, A., Simpson, E., Chandler, P., Stockinger, B., Waldmann, H., & Cobbold, S. P.
1998
Rejection of H-Y disparate skin grafts by monospecific CD4+ T helper 1 (Th1) and T helper 2 (Th2) cells: no requirement for CD8+ T cells or B cells.
J. Immunol. 161: 1868-1874.
Cobbold, S. & Waldmann, H.
1998
Infectious tolerance.
Curr. Opinion Immunol., 10 (5): 518-524.
Waldmann, H.
1998
Limiting Dilution Analysis
in Encyclopedia of Immunology 2nd Ed.
Academic Press.
In the press.
Woods, M., Guy, R., Waldmann, H., Glennie, M., and Alexander, D.R.
1998
A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2, IL-4, and IL-10 secretion and expression of CD25, CD40L, and CD69.
Cell. Immunol. 185:101-113.
Calne, R., Friend, P., Moffatt, S., Bradley, A., Hale, G., Firth, J., Bradley, J., Smith, K. and Waldmann, H.
1998
Prope tolerance, perioperative Campath 1H, and low-dose cyclosporin monotherapy in renal allograft patients.
The Lancet 351:1701-1702.
Waldmann, H., Bemelman, F., and Cobbold, S.
1998
Tolerance induction with CD4 monoclonal antibodies.
in Immunological Tolerance
Novartis Foundation Symposium 215, 146-158.
pub. Wiley, Chichester.
Revillard, J-P., Adorini, L., Goldman, M., Kabelitz, D., and Waldmann, H.
1998
Apoptosis: potential for disease therapies.
Immunology Today 19: 291.
Adorini, L., Goldman, M., Kabelitz, D., Revillard, J-P., and Waldmann, H.
1998
Apoptosis, tolerance and immunoregulation - integrated pathways for immune system homeostasis.
The Immunologist 6/2: 92-94.
Waldmann, H., & Cobbold, S.
1998
How do monoclonal antibodies induce tolerance? A role for Infectious Tolerance?
Ann. Rev. immunol. 16: 619-44.
[Abstract] [Full Text] [PDF]
Hale, G. & Waldmann, H.
1998
Risks of developing Epstein-Barr virus-related lymphoproliferative disorders after T-cell-depleted marrow transplants. CAMPATH Users.
Blood 91(8): 3079-83.
Fournel, S., Robinet, E., Bonnefoy-Berard, N., Assossou, O., Flacher, M., Waldmann, H., Bismuth, G., & Revillard, J.P.
1998
A noncomitogenic CD2R monoclonal antibody induces apoptosis of activated T cells by a CD95/CD95-L-dependent pathway.
J. Immunol. 160(9): 4313-21.
Bemelman, F., Honey, K., Adams, E., Cobbold, S., & Waldmann, H.
1998
Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.
J. Immunol. 160: 2645-2648.
Mehta, J., Powles, R., Treleaven, J., Horton, C., Shepherd, V., Hale, G., Waldmann, H., and Singhal, S.
1997
Autologous transplantation with CD52 monoclonal antibody-purged marrow for acute lymphoblastic leukaemia: long-term follow-up.
Leuk. Lymphoma 25: 479-86.
Isaacs, JD., Burrows, N., Wing, M., Keogan, M.T., Rebello, PRUB., Watts, RA.,Pye, RJ., Norris, P., Hazelman, BL., Hale, G. & Waldmann H.
1997
Humanized anti-CD4 monoclonal antibody therapy of autoimmune and inflammatory disease.
Clin. Exp. Immunol. 110: 158-166.
Hale, G. & Waldmann, H.
1997
Use of Ceprate CD34-positive selection system for depletion of T cells in allogeneic transplantation [letter; comment]
Bone Marrow transplant. 20(8):709-10.
Genestier, L., Paillot, R., Bonnefoy-Berard, N., Meffre, G., Flacher, M., Fevre, D., Liu, YL., Le Bouteiller, P., Waldmann, H., Englehard, V.H., Banchereau, J., & Revillard, JP.
1997
Fas-independent apoptosis of activated T cells induced by antibodies to the HLA Class I alpha1 domain.
Blood 90(9): 3629-3639.
Davies, J.D., Cobbold, S.P. & Waldmann, H.
1997
Strain variation in susceptibility to monoclonal antibody-induced transplantation tolerance.
Transplantation 63, 1570-1573
Dyer, M.J.S., Kelsey, S.M., Mackay, H.J., Emmett, E., Thornton, P., Hale, G. & Waldmann, H.
1997
In vivo 'purging' of residual disease in CLL with Campath-1H.
British Journal of Haematology 97, 669-672.
Genestier-L ; Paillot-R ; Bonnefoy-Berard-N ; Waldmann-H ; Revillard-JP -L
1997
T cell sensitivity to HLA class I-mediated apoptosis is dependent on interleukin-2 and interleukin-4.
Eur-J-Immunol .1997 Feb; 27(2): 495-9.
Hale, G. & Waldmann, H.
1997
Use of monoclonal antibodies for preventing graft rejection and inducing graft-host tolerance. In: Clinical Bone Marrow and Blood Stem Cell Transplantation, 2nd ed. Ed. K. Atkinson
Cambridge University Press
Killick, S., Marsh, J.C.W., Hale, G., Waldmann, H., Kelly, S.J., & Gordon-Smith, E.C.
1997
Sustained remission of severe resistant auto-immune neutropenia with Campath-1H.
Br. J. Haematol. 97(2): 306-8.
Scully, R., Cobbold, S.P., Mellor, A.L., Wissing, M., Arnold, B. & Waldmann, H.
1997
A role for Th2 cytokines in the suppression of CD8+ T-cell mediated graft rejection.
Eur.J.Imm. 27, 1663-1670.
Tone, M., Thompson, S.A.J., Tone, Y., Fairchild, P.J. & Waldmann, H.
1997
Regulation of interleukin-18 (interferon- - inducing factor) gene expression.
J. Immunol. 159(12): 6156-63.
Waldmann, H., Cobbold, S.P. & Hale, G.
1997
Grant versus Host Disease. Its control and prospects for allogeneic bone marrow transplantation
in: Immunology and Pathology of Transplantation. Ed. S. Thiru & H. Waldmann. pub. Blackwell Science
Chen, Z.K., Cobbold, S.P., Waldmann, H.& Metcalfe, S.
1996
Amplification of natural regulatory immune mechanisms for transplantation tolerance.
Transplantation 62, 1200-1206.
Cornish-JM ; Pamphilon-DH ; Potter-MN ; Steward-CG ; Goodman-S ; Green-A ; Goulden-P ; Goulden-N ; Knechtli-C ; Hale-G ; Waldmann-H ; Oakhill-A
1996
Unrelated donor bone marrow transplant in childhood ALL. The role of T-cell depletion.
Bone-Marrow-Transplant .1996 Nov; 18 Suppl 2: 31-5.
Davies, J.D., Leong, L.Y.W., Mellor, A., Cobbold, S.P. & Waldmann, H.
1996
T-cell suppression in transplantation tolerance through linked recognition.
J. Immunol. 156, 3602-3607.
Davies, J.D., Martin, G., Phillips, J., Marshall, S.E, Cobbold, S.P. & Waldmann, H.
1996
T cell regulation in adult transplantation tolerance.
J. Immunol., 157, 529-533
Fournel, S., Vincent, C., Assossou, O., Gorman, S.D., Robinet, E., Phillips, J. M., Flacher, M., Cordier, G., Waldmann, H. & Revillard, J.P.
1996
CD4 mAbs prevent progression of alloactivated CD4+ T cells into the S phase of the cell cycle without interfering with early activation signals.
Transplantation .1996 Oct 27; 62(8): 1136-43.
Hale, G. & Waldmann, H.
1996
Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection.
Bone Marrow Transplantation 17, 305-308.
Hamblin, M., Marsh, J.C.W., Lawler, M., McCann, S.R., Wickham, N., Dunlop, L., Ball, S., Davies, E.G., Hale, G., Waldmann, H. & Gordon-Smith, E.C.
1996
Campath-1G in vivo confers a low incidence of graft-versus-host disease associated with a high incidence of mixed chimaerism after bone marrow transplantation for severe aplastic anaemia using HLA-identical sibling donors.
Bone Marrow Transplantation 17, 819-824.
Isaacs-JD ; Hazleman-BL ; Chakravarty-K ; Grant-JW ; Hale-G ; Waldmann-H
1996
Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.
J-Rheumatol .1996 Jun; 23(6): 1103-6.
Isaacs-JD ; Wing-MG ; Greenwood-JD ; Hazleman-BL ; Hale-G ; Waldmann-H
1996
A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans.
Clin-Exp-Immunol .1996 Dec; 106(3): 427-33.
Lockwood, C.M., Thiru, S., Steard, S., Hale, G., Isaacs, J., Wraight, P., Elliott, J. & Waldmann, H.
1996
Treatment of refractory Wegener's granulomatosis with humanized monoclonal antibodies.
Q. J. Med. 89, 903-912.
Marshall, S.E., Cobbold, S.P., Davies, J.D., Martin, G.M., Phillips, J.M. & Waldmann, H.
1996
Tolerance and suppression in a primed immune system.
Transplantation 62, 1614-1621.
Moreau-T ; Coles-A ; Wing-M ; Isaacs-J ; Hale-G ; Waldmann-H ; Compston-A
1996
Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis.
Brain .1996 Feb; 119 ( Pt 1): 225-37.
Oakhill, A., Pamphilon, D.H., Potter, M.N., Steward, C.G., Goodman, S., Green, A., Goulden, P., Goulden, N.J., Hale, G., Waldmann, H. and Cornish, J.M.M.
1996
Unrelated donor bone marrow transplantation for children with relapsed acute lymphoblastic leukaemia in second complete remission.
British Journal of Haematology 94 574-578.
Moreau, T., Coles, A., Wing, M., Thorpe, J., Miller, D., Moseley, I., Isaacs, J., Hale, G., Clayton, D., Scolding, N., Waldmann, H., Compston, A.
1996
CAMPATH-1H in multiple sclerosis.
Mult. Scler. 1(6): 357-65.
Tone, Y., Thompson, S.A.J., Babik, J.M., Nolan, K.F., Tone, M., Raven, C. & Waldmann, H.
1996
Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes.
Eur.J.Immunol., 26, 1222-1227.
Waldmann, H. & Cobbold, S.
1996
How may immunosuppression lead to tolerance? The war analogy.
In Immune Tolerance (ed Banchereau, J., Dodet, B., Schwartz, R., Trannoy E.) Elsevier, Paris, pp 221-227.
Wing, M., Moreau, T., Greenwood, J., Smith, R., Hale, G., Isaacs, J., Waldmann, H., Lachmann, P. & Compston, A.
1996
The mechanism of first-dose cytokine relase syndrome by CAMPATH 1-H: involvement of CD16 (Fc-gamma RIII) and CD11a/CD18 (LFA-1) on NK cells.
J. Clin. Invest.98: 2819-2826
Wing, M.G., Waldmann, H., Isaacs, J., Compston, D.A.S. & Hale, G.
1996
Ex-vivo whole blood cultures for predicting cytokine release syndrome: dependence on target antigen and antibody isotype.
J. Therapeutic Immunology 98: 2819-2826.
Brons-IG ; Davies-HF ; Rasmussen-A ; Watson-CJ ; Thiru-S ; Cobbold-SP ; Waldmann-H ; Calne-RY
1995
Islet allografting in the dog model: potential therapies for tolerance induction.
Transplant-Proc .1995 Feb; 27(1): 609-10.
Brons-IG ; Davies-HS ; Watson-CJ ; Cobbold-SP ; Waldmann-H ; Calne-RY
1995
Substantial peripheral T-cell depletion before grafting is beneficial in islet transplantation.
Transplant-Proc .1995 Dec; 27(6): 3181.
Chatenoud-L ; Waldmann-H ; Emmrich-F
1995
Tolerance induction in the adult: 'danger' at Le Bischenberg [published erratum appears in Immunol Today 1995 Apr;16(4):172]
Immunol-Today .1995 Mar; 16(3): 121-3.
Cobbold, S.P., Adams, E., Marshall, S.E., Davies, J.D. & Waldmann, H.
1996
Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8.
Immunol. Revs. 148, 1-29.
Diamond, L.E., McCurry, K.R., Oldham, E.R., Tone, M., Waldmann, H. Platt, J.L. & Logan, J.S.
1995
Human CD59 expressed in transgenic mouse hearts inhibits the activation of complement.
Transplant. Immunology 3, 305-312.
Hale-G ; Waldmann-H
1995
Availability of Campath-1 antibodies for bone marrow transplantation [letter; comment]
Bone-Marrow-Transplant .1995 Feb; 15(2): 327.
Isaacs, JD., Hale, G., Waldmann, H., Dick, AD., Haynes, R., Forrester, JV., Watson, P., Meyer, PA.
1995
Monoclonal antibody therapy of chronic intraocular inflammation using CAMPATH-1H [letter]
Br. J. Opthamol. 79(11): 1054-5.
Kooyman, D.L., Byrne, G.W., Maclellan, S., Nielsen, D., Tone, M., Waldmann, H., Coffman, T.M., McCurry K.R., Platt, J.L. & Logan, J.S.
1995
In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium.
Science 269, 89.
Newman, DK., Isaacs, JD., Watson, PG., Meyer, PA., Waldmann, H.
1995
Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H.
Eye 9: 564-9.
Routledge, E. & Waldmann, H.
1995
The effect of aglycosylation on the immunogenicity of a humanised therapeutic CD3 antibody.
Transplantation 60, 847.
Spencer-A ; Szydlo-RM ; Brookes-PA ; Kaminski-E ; Rule-S ; van-Rhee-F ; Ward-KN ; Hale-G ; Waldmann-H ; Hows-JM ; et-al
1995
Bone marrow transplantation for chronic myeloid leukemia with volunteer unrelated donors using ex vivo or in vivo T-cell depletion: major prognostic impact of HLA class I identity between donor and recipient.
Blood .1995 Nov 1; 86(9): 3590-7.
Watson-CJ ; Davies-HF ; Cobbold-SP ; Rasmussen-A ; Rebello-PR ; Thiru-S ; Waldmann-H ; Calne-RY ; Metcalfe-SM
1995
CD4 and CD8 monoclonal antibody therapy in the dog: strategies to induce tolerance to renal allografts.
Transplant-Proc .1995 Feb; 27(1): 123-4.
Abbs, I.C., Clark, M., Waldmann, H., Chatenoud, L., Koffman, C.G. & Sacks, S.H.
1994
Sparing of first dose effect of monovalent anti-CD3 antibody used in allograft rejection is associated with a diminished release of pro-inflammatory cytokines
J. Therapeutic Immunology 6: 325-332
Brons-IG ; Davies-HS ; Makisalo-H ; Rasmussen-A ; Cobbold-SP ; Waldmann-H ; Calne-RY
1994
Transplantation of immunomodulated dog islets.
Transplant-Proc .1994 Apr; 26(2): 754.
Chen-Z ; Cobbold-S ; Waldmann-H ; Metcalfe-S
1994
Combined use of RS61443 with CD4 and CD8 MAbs to generate tolerance to skin xenografts from rat
Transplant-Proc .1994 Aug; 26(4): 2433-4.
Chen-Z ; Cobbold-SP ; Waldmann-H ; Metcalfe-SM
1994
Tolerance induction in concordant heart-xenografted mice by CD4 and CD8 monoclonal antibodies.
Transplant-Proc .1994 Jun; 26(3): 1199-200.
Davies-HS ; Cobbold-SP ; Watson-CJ ; Metcalfe-SM ; Rebello-PR ; Thiru-S ; McNair-R ; Rasmussen-A ; Waldmann-H ; Calne-RY
1994
Production, selection, and testing of monoclonal antibodies to canine leukocytes in the dog kidney allograft model.
Transplant-Proc .1994 Aug; 26(4): 1941-2.
Fuller, B.E., Girald, A.A., Waldmann, H., Cobbold, S.P. & Kong, Y-C.M.
1994
Depletion of CD4+ and CD8+ cells eliminates immunologic memory of thyroiditogenicity in murine experimental autoimmune thyroiditis.
Autoimmunity 19, 161-168.
Gorman, S.D., Frewin, M.R., Cobbold, S.P. & Waldmann, H.
1994
Isolation and expression of cDNA encoding the canine CD4 and CD8 alpha antigens.
Tissue Antigens. 43(3): 184-8
Greenwood,J., Gorman, S.D., Routledge,E.G., Lloyd, I.S. and Waldmann H.
1994
Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H. Effects on complement lysis..
J. Therapeutic Immunology 1:247-256
Hale, G & Waldmann,H.
1994
CAMPATH-1 monoclonal antibodies in bone marrow transplantation.
J. Hematother. 3(1): 15-31
Hale, G. & Waldmann, H.
1994
Control of graft-versus-host disease and graft rejection by T cell depletion of donor and recipient with Campath-1 antibodies. Results of matched sibling transplants for malignant diseases.
Bone Marrow Transplant. 13(5): 597-611
Isaacs,J. & Waldmann, H.
1994
Helplessness as a strategy for avoiding antiglobulin responses to therapeutic monoclonal antibodies.
J. Therapeutic Immunology 1. 303-312
Jacobs, P., Wood, L., Fullard, L., Waldmann, H. & Hale, G.
1994
T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease.
Bone Marrow Transplant. 13(6): 763-9
Marshall, S.E. & Waldmann, H.
1994
Monoclonal antibodies in therapeutic transplantation.
In Kupciek Weginski ed. New Immunosuppressive modalities in anti-rejection approaches in organ transplantation. Reed Intelligence Unit. USA Therapeutic Transplantation.
Moreau, T., Thorpe, J., Miller, D., Moseley, I., Hale, G., Waldmann, H., Clayton, D., Wing, M., Scolding, N. & Compston, A.
1994
Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis.
Lancet. 344: 298-301
Scully, R., Qin, S., Cobbold, S.P. & Waldmann, H.
1994
Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells.
Europ. J. Immunol 24: 2383-2392
Waldmann, H., Cobbold, S.P. and Hale, G.
1994
What can be done to prevent Graft versus Host Disease?
Current Opinions in Immunology 6:777-784
Watson, C.J., Cobbold, S.P., Davies, H.S., Rebello, P.R., Thiru, S., McNair, R., Rasmussen, A., Waldmann, H., Calne, R.Y., & Metcalfe, S.M.
1994
Immunosuppression of canine renal allograft recipients by CD4 and CD8 monoclonal antibodies.
Tissue Antigens. 43(3): 155-62
Greenwood, J., Clark, M. & Waldmann, H.
1993
Structural motifs involved in IgG effector functions.
Eur.J.Immunol. 23: 1098-1104
Lockwood, C.M., Thiru S., Isaacs J.D., Hale G. & Waldmann H.
1993
Humanised monoclonal antibody therapy for intractable systemic vasculitis.
Lancet. 341: 1620-2
Bolt S., Routledge E., Lloyd I., Chatenoud L., Pope H., Gorman S., Clark, M. and Waldmann, H.
1993
The generation of humanised, non-mitogenic CD3 monoclonal antibody which retains in-vitro immunosuppressive properties.
Europ. J. Immunol. 23: 403-11
Chen, Z., Cobbold, S., Waldmann, H. & Metcalfe, S.
1993
Stability of tolerance in mice generated by CD4 and CD8 monoclonal antibody treatment: cell transfer experiments.
Transplantation Proceedings 25, 790-791.
Cullis, J.G., Szydlo, R,M., Cross, N.C.P., Marks, D.I., Schwarer, A.P., Hughes, T.P., MacKinnon, S., Hale, G., Waldmann, H., Hows ,J.M., Barrett, A.J. & Goldmann, J.M.
1993
Matched unrelated donor bone marrow transplantation for chronic myeloid leukaemia in chronic phase: comparison of ex vivo and in vivo T-cell depletion .
Bone Marrow Transplant. 11 Suppl 1: 107-11
Davies, J.D. & Waldmann, H.
1993
Monoclonal Antibodies in Transplantation.
In Rose, M. & Yacoub, M. Eds. Immunology of Heart and Lung Transplantation. Edward Arnold, 93-116.
Greenwood, J., Clark, M. & Waldmann, H.
1993
Structural motifs involved in human IgG antibody effector functions.
Eur.J.Immunol. 23(5), 1098.
Hale, G. & Waldmann, H. for the CAMPATH users
1993
Monoclonal antibodies for preventing graft rejection and inducing tolerance.
In ""Clinical Bone Marrow Transplantation: A Textbook"" (ed. K. Atkinson) Cambridge University Press.
Hayward, A.R., Shriber, M., Cooke, A. & Waldmann, H.
1993
Prevention of diabetes but not insulitis in NOD mice injected with antibody to CD4:
J. Autoimmun. 6: 301-10
Hutchings, P.R., Cooke, A., Dawe, K., Waldmann, H. & Roitt, I.M.
1993
Active suppression induced by anti-CD4.
Eur.J.Immunol. 23(4) 965-8.
Lim, S.H., Hale, G., Marcus, R.E., Waldmann, H. & Baglin, T.P.
1993
CAMPATH-1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura.
Br.J.Haematol. 84(3): 542-4
O'Neill, J.K., Baker, D., Davison, A.N., Allen, S.J., Butter, C., Waldmann, H. & Turk, J.L.
1993
Control of immune-mediated disease of the central nervous system with monoclonal (CD4-specific) antibodies.
J-Neuroimmunol. 45(1-2): 1-14
Parish NM; Hutchings PR; Waldmann H; Cooke A.
1993
Tolerance to IDDM induced by CD4 antibodies in nonobese diabetic mice is reversed by cyclophosphamide.
Diabetes. 1993 42(11): 1601-5
Qin, S., Cobbold, S.P. Pope, H., Elliott, J., Kioussis, D. & Waldmann, H.
1993
Infectious Transplantation Tolerance.
Science. 12; 259: 974-7
Sims, M.J., Hassal, D.G., Brett, S., Rowan, W., Lockyer, M.J., Angel, A., Hale, G., Waldmann, H. & Crowe, S.
1993
Selection and functional characterisation of humanised CD18 antibody. A humaized CD18 antibody can block function without cell destruction.
J. Immunol. 151(4), 2296-2308.
Waldmann H. & Cobbold, S.
1993
Monoclonal antibodies for the induction of transplantation tolerance.
Curr.Opin.Immunol. 5(5): 753-8.
Waldmann H., Qin Shixin and Cobbold SP.
1993
Monoclonal antibodies for the therapeutic induction of tolerance.
in Bach JF ed. ""Monoclonal Antibodies and peptide therapy in Autoimmune Diseases. Marcel Dekker. Immunol. Ser. 59, 85-99. Chapter 5 pp 85-99.
Waldmann, H. & Cobbold,S.
1993
The use of monoclonal antibodies to achieve immunological tolerance.
Trends Pharmacol. Sci. 14(5): 143-8
Waldmann, H., Qin, S., Leong, Y.W.L. & Cobbold, S.P.
1993
Reprogamming the immune system
in Thomas Donnell ed. Application of Basic Science to Hematopoiesis and Treatment of Disease. Raven Press.
Watson, C.J., Cobbold, S.P., Davies, H.S,, Rebello, P.R., Waldmann, H., Calne, R.Y. & Metcalfe, S.M.
1993
CD4 and CD8 monoclonal antibody therapy: strategies to prolong renal allograft survival in the dog.
Br.J.Surg. 80(11): 1389-92.
Xia, M.Q., Hale, G. & Waldmann, H.
1993
Efficient complement-mediated lysis of cells containing the CAMPATH-1 (Cdw52) antigen.
Mol. Immunol. 30(12), 1089-96.
Xia, M.Q., Hale, G., Lifely, M.R., Ferguson, M.A., Campbell, D., Packman, L. & Waldmann, H.
1993
Structure of the CAMPATH-1 antigen, glycosylphosphatidylinositol anchored glycoprotein which is an exceptionally good target for complement lysis
Biochem.J. ; 293 : 633-40.
Chen, Z., Cobbold, S.P., Metcalfe, S. & Waldmann, H.
1992
Tolerance in the mouse to MHC mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8.
Eur. J. Immunol. 22, 805-810.
Cobbold S.P., Qin Shixin., Leong, L.Y.W ., Martin, G. & Waldmann, H.
1992
Reprogramming the Immune System for peripheral tolerance with CD4 and CD8 monoclonal antibodies.
Immunol. Rev 129: 165-201.
Hutchings, P., O'Reilly, L., Parish, N.M., Waldmann, H. & Cooke, A.
1992
The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to b cells in NOD mice.
Eur. J. Imunol. 22, 1913-1918.
Isaacs, J.D., Clark, M.R., Greenwood, J. & Waldmann, H.
1992
Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential.
Journal of Immunology, 148, 3062-3071.
Isaacs, J.D., Watts, R.A., Hazleman, B.L., Hale, G., Keogan, M.T., Cobbold, S.P. & Waldmann, H.
1992
Humanised monoclonal antibody therapy for rheumatoid arthritis.
Lancet .340; 748-752
Leong LYW., Qin Shixin., Cobbold SP., and Waldmann H.
1992
Classical Transplantation Tolerance in the Adult. The interaction between myeloablation and immunosuppression.
Europ. J. Immunol. : 22: 2825-30
Lockwood, C.M., Thru, S., Isaacs, J.D., Hale, G. & Waldmann, H.
1992
Humanised monoclonal antibody therapy for intractable systemic vasculitis.
Lancet 341, 1620-1622.
Nabozny, G.H., Cobbold, S.P., Waldmann, H. & Kong, Yi-chi.
1992
Suppression in Murine Experimental Autoimmune Thyroiditis: In Vivo Inhibition of CD4+ T Cell-Mediated Resistance by a Nondepleting Rat CD4 Monoclonal Antibody.
Cellular Immunology 138. .
Tone, M., Walsh, L.A. & Waldmann, H.
1992
Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation.
J. Mol. Biol. 227: 971-976
Waldmann, H.
1992
Selective depletion of alloreactive cells in transplantation.
In Solheim et al. eds. The HLA system in clinical transplantation. Chapter 22. Springer Verlag.
Waldmann, H., Qin Shixin, Leong, L.Y.W. & Cobbold, S.P.
1992
In vivo use of monoclonal antibodies for modulation of the immune response.
Forum trends in experimental and clinical medicine 2: 250- 261
Waldmann, H., Qin, S. & Cobbold, S.
1992
Monoclonal antibodies as agents to reinduce tolerance in immunity.
Journal of Autoimmunity , 5, 93-102.
Walsh, L.A., Tone, M., Thiru, S. & Waldmann, H.
1992
The CD59 antigen - a multifunctional molecule.
Tissue Antigens. 40: 213-20
Willemze, R., Richel, D.J., Falkenburg, J.H.F., Hale, G., Waldmann, H., Zwaan, F.E. & Fibbe, W.E.
1992
In vivo use of Campath-1-G to prevent graft-versus-host disease and graft rejection after bone marrow transplantation.
Bone Marrow Transplantation. 9: 255-61
Wise, M. Benjamin, R., Qin, S., Cobbold, S. & Waldmann, H.
1992
Tolerance induction in the peripheral immune system.
Molecular Mechanisms of Immunological Self-Recognition. Vogel H and Alt F eds. Acad. Press Inc.p 149-155.
Friend, P.J., Waldmann, H., Cobbold, S., Tighe, H., Rebello, P., Wight, D., Gore, S., Pollard, S., Lim, S. & Johnston, P.
1991
The anti-IL-2 receptor monoclonal antibody YTH-906 in liver transplantation.
Transplant. Proc. 23, 1390-1392.
Friend, P.J., Waldmann, H., Hale, G., Cobbold, S., Rebello, P., Thiru, S., Jamieson, N.V., Johnston, P.S. & Calne, R.Y.
1991
Reversal of allograft rejection using the monoclonal antibody, CAMPATH-1G.
Transplant Proc. 23, 2253-2254.
Gorman, S.D., Clark, M.R., Routledge, E.G., Cobbold, S.P. & Waldmann, H.
1991
Reshaping a therapeutic CD4 antibody.
Proc. Natl. Acad. Sci. 88, 4181-4185.
Meng-Qi, X., Tone, M., Packman, L., Hale, G. & Waldmann, H.
1991
Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone.
Eur. J. Immunol. 21, 1677-1684.
Meri, S., Waldmann, H. & Lachmann, P.
1991
Distribution of Protection (CD59), a Complement Membrane Attack Inhibitor, in Normal Human Tissues.
Laboratory Investigation. 65, 532-537.
Routledge, E.G., Lloyd, I., Gorman, S., Clark, M. & Waldmann, H.
1991
A Humanized Monovalent CD3 Antibody which can Activate Homologous Complement.
Eur. J. Immunol. 21, 2717-2725
Waldmann, H.
1991
Limiting Dilution Analysis.
Encyclopedia of Immunology. 979-981.
Waldmann, H., Cobbold, S., Qin, S. & Leong, L.
1991
Transplantation Tolerance with Monoclonal Antibodies.
in Burlingham W. Ed. Monoclonal Antibody Therapy. CRC Press. (in Press).
Walsh, L. A., Tone, M. & Waldmann, H.
1991
Transfection of human CD59 complementary DNA into rat cells confers resistance to human complement.
Eur. J. Immunol. 21, 847-850.
Watt, S.M., Sala-Newly, G., Hoang, T., Gilmore, D.J., Grunert, F., Nagel, G., Murdoch, S.J., Tchilian, E., Lennox, E.S. & Waldmann, H.
1991
CD66 identifies a neutrophil - specific epitope within the hematopoietic system that is expressed by members of the carcinoembryonic antigen family of adhesion molecules.
Blood, 78, 63-74.
Bindon, C.I., Hale, G. & Waldmann, H.
1990
Complement activation by immunoglobulin does not depend solely on Clq binding.
Eur. J. Immunol. 20, 277-281.
Clark, M., Bolt, S., Tunnacliffe, A. & Waldmann, H.
1990
Use of bispecific monoclonal antibodies to treat hematological malignancies: a model system using CD3 transgenic mice.
In: Bispecific antibodies and targeted cellular cytotoxicity: Second international conference, J.L. Romet-Lemonne, M.W. Fanger & D.M. Segal (Eds), pp. 243-247.
Cobbold, S.P., Hale, G., Clark, M.R. & Waldmann, H.
1990
Purging in auto- and allografts: monoclonal antibodies which use human complement and other natural effector mechanisms.
Prog. Clin. Biol. Res. 333. 139-151.
Cobbold, S.P., Martin, G. & Waldmann, H.
1990
The Induction of Skingraft Tolerance in MHC-Mismatched or Primed Recipients: primed T-cells can be tolerized in the periphery with CD4 and CD8 antibodies.
Eur. J. of Immunol. 20, 2747-2755.
Cobbold, S.P., Qin, S. & Waldmann, H.
1990
Reprogramming the immune system for tolerance with monoclonal antibodies.
Seminars in Immunology 2, 377-387.
Dyer, M.J., Hale, G., Marcus, R. & Waldmann, H.
1990
Remission Induction in Patients with Lymphoid Malignancies Using Unconjugated CAMPATH-1 Monoclonal Antibodies.
Leukemia and Lymphoma 2, 179-193.
Hale, G., Xia, M-Q., Tighe, H.P., Dyer, M.J.S. & Waldmann, H.
1990
The CAMPATH-1 Antigen (CDw52).
Tissue Antigens 35, 118-127.
Hutchings, P.R., Simpson, E., O'Reilly, L.A., Waldmann, H., Lund, T. & Cooke, A.
1990
The Involvement of Ly2+ T Cells in Beta Cell Destruction.
J. of Autoimmunity 3, 101-109.
Mackinnon, S., Hows, J.M., Goldman, J.M., Arthur, C.K., Hughes, T., Apperley, J.F., Jones, L., Batchelor, J.R., Brookes, P., Catovsky, D., Galton, D.A.G., Bidwell, J., Bradley, B., Cleaver, S., Hale, G. & Waldmann, H.
1990
Bone Marrow Transplantation for Chronic Myeloid Leukemia: The Use of Histocompatible Unrelated Volunteer Donors.
Exp. Hematol. 18, 421-425.
Mathieson, P.W., Cobbold, S.P., Hale, G., Clark, M.R., Oliveira, D.B.G., Lockwood, C.M. & Waldmann, H.
1990
Monoclonal Antibody Therapy in Systemic Vasculitis.
New Eng J. Med. 323, 250-254.
Meri, S., Morgan, B.P., Davies, A., Daniels, R.H., Olavesen, M.G., Waldmann, H. & Lachmann, P.J.
1990
Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.
Immunology 71, 1-9.
Qin, S., Wise, M., Cobbold, S., Leong, L., Kong, Yi-Chi, Parnes, J.R. & Waldmann, H.
1990
Induction of tolerance in peripheral T cells with monoclona antibodies.
Eur. J. of Immunol. 20, 2737-2745.
Routledge, E., Lloyd, I., Gorman, S. & Waldmann, H.
1990
A monovalent humanized antibody bispecific for the human CD3 antigen complex.
In: Bispecific antibodies and targetted cellular cytotoxicity. Second international conference, J.L. Romet-Lemonne, M.W. Fanger & D.M. Segal (Eds), pp. 157-164.
Waldmann, H.
1990
(Editor). Introduction: Therapeutic approaches to the induction of specific unresponsiveness.
Seminars in Immunology 2., 375. Saunders Scientific Publications.
Waldmann, H., Cobbold, S., Clark, M., Hale, G., Qin, S. & Wise, M.
1990
The Generation of Immunological Tolerance as a Therapeutic Procedure.
Horizons in Medicine, Ed. L.K. Borysiewicz.
Waldmann, H., Hale, G., Cobbold, S., Clark, M., Qin, S., Benjamin, R. & Dyer, M.J.S.
1990
Monoclonal Antibody Therapy for the Prevention of Graft-vs.-Host Disease. (Ed. S J Burakoff., H.J. Deeg, J. Ferrara and K. Atkinson, Publ. Marcel Dekker Inc. N.Y. & Basel.
Hematology, 12, 277-293.
Brewer, Y., Palmer, A., Taube, D., Welsh, K., Bewick, M., Bindon, C., Hale, G., Waldmann, H., Dische, F., Parsons, V. & Snowden, S.
1989
Effect of Graft Perfusion with Two CD45 Monoclonal Antibodies on Incidence of Kidney Allograft Rejection.
The Lancet, II, 935-937.
Bruggemann, M., Caskey, H.M., Teale, C., Waldmann, H., Williams, G.T., Surani, M.A. & Neuberger, M.S.
1989
A repertoire of monoclonal antibodies with human heavy-chains from transgenic mice.
Proc. Natl. Acad. Sci. 86, 6709-6713.
Bruggemann, M., Teale, C., Bindon, C., Clark, M. & Waldmann, H.
1989
A Matched Set of Rat/Mouse Chimeric Antibodies: Identification and Biological Properties of Rat H Chain Constant Regions m. g1, g2a, g2b, g2c, e, and a1
J. of Immunol. 142, 3145-3150.
Bruggemann, M., Winter G., Waldmann, H. & Neuberger, M.S.
1989
The Immunogenicity of chimeric antibodies.
J. Exp. Med. 170, 2153-2157.
Clark, M., Bindon, C., Dyer, M., Friend, P., Hale, G., Cobbold, S., Calne, R. & Waldmann, H.
1989
The improved lytic function and in vivo efficacy of monovalent monoclonal CD3 antibodies.
Eur. J. Immunol. 19, 381-388.
Cobbold, S., Barel, D. & Waldmann, H.
1989
Manipulating the immune system with monoclonal antibodies: mouse models for immunotherapy.
In T Cells Ed. M. Feldman. Pub. John Wiley.
Davies, A., Simmons, D.L., Hale, G., Harrison, R.A., Tighe, H., Lachmann, P.J. & Waldmann, H.
1989
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.
J. Exp. Med. 170, 637-654.
Day, M.J., Elson, C.J., Cobbold, S.P. & Waldmann, H.
1989
Adoptive Suppression of Erythrocyte Autoantibodies in Lyt-2+ Depleted Recipients.
Autoimmunity 3, 39-45.
Dyer, M.J.S., Hale, G., Hayhoe, F.G.J. & Waldmann, H.
1989
Effects of CAMPATH-1 Antibodies in vivo in Patients with Lymphoid Malignancies: Influence of Antibody Isotype.
Blood 73, 1431-1439.
Flynn, J.C., Conaway, D.H., Cobbold, S., Waldmann, H. & Kong, Y.M.
1989
Depletion of L3T4+ and Lyt-2+ Cells by Rat Monoclonal Antibodies Alters the Development of Adoptively Transferred Experimental Autoimmune Thyroiditis.
Cell. Immunol. 122, 377-390.
Frame, J.N., Collins, N.H., Cartagena, T., Waldmann, H., O.Reilly, R.J., Dupont, B. & Kernan, N.A.
1989
T cell depletion of human bone marrow. Comparison of Campath-1 plus complement, anti T cell ricin A chain immunotoxin, and soybean agglutinin alone or in combination with sheep erythrocytes or immunomagnetic beads.
Transplantation 47, 984-988.
Friend, P.J., Hale, G., Waldmann, H., Gore, S., Thiru, S., Joysey, V., Evans, D.B. & Calne, R.Y.
1989
Campath -1M prophylactic use after kidney transplantation. A randomized controlled clinical trial.
Transplantation. 48, 248-253.
Hale G., Xia. M. & Waldmann, H.
1989
Purification and preliminary characterisation of the CAMPATH-1 antigen.
Tissue Antigens 33, 290.
Hale, G., Cobbold, S. & Waldmann, H.
1989
Cluster analysis using percentage or mean fluorescence: comparison indicates that future workshop analysis could be improved and simplified.
Tissue Antigens 33, 363.
Kong, Y.M., Giraldo, A.A., Waldmann, H., Cobbold, S.P. & Fuller, B.
1989
Resistance to experimental autoimmune thyroiditis: L3T4+ cells as mediators of both thyroglobulin-activated and TSH-induced suppression.
Clin. Immunol. Immunopathol. 51, 38-54.
Kong, Y.M., Waldmann, H., Cobbold, S., Giraldo, A.A., Fuller, B.E. and Simon, L.L.
1989
Pathogenic mechanisms in murine autoimmune thyroiditis: short- and long-term effects of in vivo depletion of CD4+ cells and CD8+ cells.
Clin. Exp. Immunol. 77, 428-433.
Kyle, V., Coughlan, R.J., Tighe, H., Waldmann, H. & Hazleman, B.L.
1989
Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis.
Ann. Rheum. Dis. 48, 428-429.
Qin, S., Cobbold, S., Benjamin, R. & Waldmann, H.
1989
Induction of classical transplantation tolerance in the adult.
J. Exp. Med. 169, 779-794.
Liew, F.Y., Millot, S., Lelchuk, R.,Cobbold, S. & Waldmann, H.
Clin. Exp. Immunol. 75, 438-443 (1989)
Effect of CD4 monoclonal antibody in vivo on lesion development, delayed-type hypersensitivity and interleukin 3 production in experimental murine cutaneous leishmaniasis.
Waldmann, H.
1989
Manipulation of T-cell responses with monoclonal antibodies.
Ann. Revs. Immunol. 7, 407-444.
Waldmann, H., Cobbold, S.P. & S. Qin,
1989
Tolerance Induction Using CD4 and CD8 Monoclonal Antibodies.
Progress in Immunology VII, 147-155.
Waldmann, H., Cobbold, S.P., Qin, S., Benjamin, R.J. & Wise, M.
1989
Tolerance Induction in the Adult Using Monoclonal Antibodies to CD4, CD8 and CD11a (LFA-1).
54th Symposium on Quantitative Biology : Immunological Recognition : Cold Spring Harbour Lab. Press. LIV, 885-892.
Williams, R.O., Whyte, A. & Waldmann, H.
1989
Resistance to collagen-induced arthritis in DBA/1 mice by intraperitoneal administration of soluble type II collagen involves both CD4+ and CD8+ T lymphocytes.
Autoimmunity. 4, 237-245.
Zamoyska, R., Waldmann, H. & Matzinger, P.
1989
Peripheral tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses.
Eur. J. Immunol. 19, 111-117
Benjamin, R.J., Shixin, Q., Wise, M.P., Cobbold, S.P. & Waldmann, H.
1988
Mechanisms of monoclonal antibody-facilitated tolerance induction: a possible role for the CD4 (L3T4) and CD11a (LFA-1) molecules in self-non-self discrimination.
Europ. J. Immunol. 18, 1079-1088.
Bindon, C.I., Hale, G. & Waldmann, H.
1988
Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies.
Eur. J. Immunol. 18, 1507-1514.
Bruggemann, M., Delmastro-Galfre, P., Waldmann, H. & Calabi, F.
1988
Sequence of a rat immunoglobulin g2c heavy chain constant region cDNA: extensive homology to mouse g3.
Eur. J. Immunol. 18, 317-319.
Friend PJ., Tighe H., Waldmann H., Lim S., D St. J Collier., Cambell D., Thiru S. & Calne RY.
1988
Monoclonal antibodies that recognise activated human lymphocytes-experimental and clinical studies.
Trans. proc. XX No1 Supp1 pp 265-266
Gilliland, L.K., Clark, M.R. & Waldmann, H.
1988
Universal bispecific antibody for targeting tumour cells for destruction by cytotoxic T cells.
Proc. Natl. Acad. Sci. 85, 7719-7723.
Hale, G. Clark, M.R., Marcus, R., Winter, G., Dyer, M.J.S., Phillips, J.M., Riechmann, L. & Waldmann, H.
1988
Remission Induction in Non-hodgkin Lymphoma with Reshaped Human Monoclonal Antibody CAMPATH-1H
Lancet II, 1394-1399.
Hale, G., Bindon, C., Clark, M., Dyer, M. & Waldmann, H.
1988
Complement activation by monoclonal antibodies.
Sandoz 14, 30-41.
Hale, G., Cobbold, S.P. & Waldmann, H.
1988
T Cell Depletion with Campath-1 in Allogeneic Bone Marrow Transplantation.
Transplantation 45, 753-759.
Riechmann, L. Clark, M., Waldmann, H., & Winter, G.
1988
Reshaping human antibodies for therapy.
Nature 332, 323-327.
Waldmann, H., Cobbold, S., Benjamin, R. & Qin, S.
1988
A Theoretical Framework for Self-tolerance and its Relevance to Therapy of Auto-immune Disease.
J. Autoimmunity 1, 623-629
Waldmann, H., Hale, G., Clark, M. et al
1988
Monoclonal antibodies for Immunosuppression.
Progress in Allergy, 45, 16-30. Pub. S. Karger AG, Basel.
Aqel, N.M. Clark, M.R., Jones, D.B., Arno, J. & Waldmann, H.
1987
Identification of Cells of the Human Mononuclear Phagocyte System with Rat Monoclonal Antibodies.
J. Pathology. 152, 265-273.
Bindon, C., Hale, G., Bruggemann, M. & Waldmann, H.
1987
Human monoclonal IgG isotypes differ in complement activating function at the level of C4 binding as well as C1q.
J. Exp. Med. 168, 127-142.
Bindon, C.I., Hale, G., Hughes-Jones, N., Gorick, B. & Waldmann, H.
1987
Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways.
Mol. Immunol. 24, 587-594.
Bruggemann, M., Williams, G.T., Bindon C.I., Clark, M.R., Walker, M.R., Jefferies, R., Waldmann, H. & Neuberger, M.S.
1987
Comparison of the Effector Functions of Human Immunoglobulins Using a Matched Set of Chimeric Antibodies.
J. Exp. Med. 166, 1351-1361.
Clark, M., Gilliland, L. & Waldmann, H.
1987
The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy.
Br. J. Cancer 56, 509.
Clark, M.R. & Waldmann, H.
1987
T Cell Killing of Target Cells Induced by Hybrid Antibodies: A Comparison of Two Bispecific Monoclonal Antibodies.
J. Natl. Canc. Inst. 79, 1393-1401.
Cobbold, S.P., Hale, G. & Waldmann, H.
1987
Non-lineage, LFA-1 family, and leucocyte common antigens: new and previously defined clusters.
Leucocyte Typing III Oxford University Press P. 780. McMichael A. ed.
Friend PJ., Tighe H., Lim S., ST J Collier, M., DeCurtins LK., Gilliland LK., Thiru S., Calne R., & Waldmann H.
1987
The use of monoclonal antibodies against activated human T-cells following renal allografting in the baboon.
Transplant. Proc. XIX pp4317-4318
Friend, P.J., Calne, R.Y., Hale, G., Waldmann, H., Evans, D.B., Rolles, K., Thiru, S. & Gore, S.
1987
Prophylactic Use of an Antilymphocyte Monoclonal Antibody Following Renal Transplantation: A Randomized Controlled Trial.
Transpl. Proc. XIX, 1898-1900.
Hale, G., Buckie, C., Lovat, P., Prospero, T. & Waldmann, H.
1987
Epitope mapping of the human leucocyte common antigen by competitive binding and synergistic lysis.
. Oxford University Press, p. 811. McMichael A. ed.
Hale, G., Cobbold, S.P., Waldmann, H., Easter, G., Matejtschuk, P. & Coombs, R.R.A.
1987
Isolation of low-frequency class-switch variants from rat hybrid myelomas.
J. Immunol. Methods 103, 59-67.
Kantwerk, G., Cobbold, S., Waldmann, H. & Kolb, H.
1987
L3T4 and Lyt2 T cells are both involved in the generation of low dose streptozotocin-induced diabetes in mice.
Clin Exp. Immunol. 70, 585-592.
Leist, T.P., Cobbold, S.P., Waldmann, H., Aguet, M. & Zinkernagel, R.M.
1987
Functional analysis of T lymphocyte subsets in antiviral host defence.
J. Immunol. 138, 2278-2281.
Lightman, S., Cobbold, S., Waldmann, H., et. al.
1987
Do L3T4+ T cells act as effector cells in protection against influenza virus infection.
Immunology, 62, 139-144.
Moskophidis, D., Cobbold, S.P. Waldmann, H. & Lehmann-Grube, F.
1987
Mechanism of Recovery from Acute Virus Infection: Treatment of Lymphocytic Choriomeningitis Virus-Infected Mice with Monoclonal Antibodies Reveals that Lyt-2+ T Lymphocytes Mediate Clearance of Virus and Regulate the Antiviral Antibody Response.
J. of Virol. 61, 1867-1874
Muller, I., Cobbold, S.P., Waldmann, H. & Kauffmann, S.H.E.
1987
Impaired Resistance to Mycobacterium tuberculosis Infection after Selective in vivo Depletion of L3T4+ and Lyt-2+ T Cells.
Infection & Immunity 55, 2037-2041.
Nash, A.A., Jayasuriya, A., Phelan, J., Cobbold, S.P., Waldmann, H. & Prospero, T.
1987
Different Roles for L3T4+ and Lyt2+ T Cell Subsets in the Control of an Acute Herpes Simplex Virus Infection of the Skin and Nervous System.
J. Gen. Virol. 68, 825-833.
Qin, Shixin, Cobbold, S.P., Tighe, H., Benjamin, R. & Waldmann, H.
1987
CD4 monoclonal antibody pairs for immunosuppression and tolerance induction.
Europ. J. Immunol. 17, 1159-1165.
Tighe, H., Clark, M. & Waldmann, H.
1987
Blocking of Cytotoxic T Cell Function by Monoclonal Antibodies Against the CD45 Antigen (T200/leukocyte-common antigen).
Transplantation 44, 818-823.
Tighe, H., Friend, P.J., Collier, St. J., Decurtins, M., Lim S., Cobbold, S.P., Thiru, S., Calne, R.Y. & Waldmann, H.
1987
Delayed allograft rejection in primates treated with anti-IL2 receptor monoclonal antibody CAMPATH-6.
Transplantation 45, 226-228.
Waldmann, H., Cobbold, S.P. & Lefkovits, I.
1987
Limiting dilution analysis.
GGB Klaus ed. IRL Press.
Waldmann, H., Cobbold, S.P., Qin, Shixin, et al
1987
Peters D.K. ed. Monoclonal antibodies for depletion of specific subpopulations of lymphocytes.
Ciba Symposia Autoimmunity. p.194.
Waldmann, H., Hale, G. & Cobbold, S.P.
1987
The immunobiology of bone marrow transplantation.
Leucocyte Typing III. Oxford University Press, p.932. McMichael A. ed.
Watt, S.M., Gilmore, D.J., Davis, J.M., Clark, M.R. & Waldmann, H.
1987
Cell surface markers on haemopoietic precursors. Reagents for the isolation and analysis of progenitor cell subpopulations.
Mol. Cell. Probes 1, 297-326.
Apperley, J.F., Jones, L., Hale, G., Waldmann., H., Hows, J., Rombos, Y., Tsatalas, C., Marcus, R.E., Goolden, A.W.G., Gordon-Smith, E.C., Catovsky, D., Galton, D.A.G. & Goldman, J.M.
1986
Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with CAMPATH-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse.
Bone Marrow Transplantation 1, 53-66.
Benjamin, R.J. & Waldmann, H.
1986
Induction of tolerance by monoclonal antibody therapy.
Nature 320, 449-451.
Benjamin, R.J. Cobbold, S.P., Clark, M.R. & Waldmann, H.
1986
Tolerance of Rat Monoclonal Antibodies: Implications for Serotherapy.
J. Exp. Med. 163, 1539-1552.
Bruggemann, M., Free, J., Diamond, A., Howard, J., Cobbold, S.P. & Waldmann, H.
1986
Immunoglobulin heavy chain locus of the rat: Striking homology to mouse antibody genes.
Proc. Natl. Acad. Sci. 83, 6075-6079.
Clark, M. & Waldmann, H.
1986",,"in Methods in Hematology (ed Beverly, P.) pub. Churchill Livingstone 13, 1-20.
Cobbold, S.P., Martin, G. & Waldmann, H.
1986
Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection: The depletion of T-cell subsets in vitro and in vivo1.
Transplantation 42, 239-247.
Cobbold, S.P., Martin, G., Qin, S., & Waldmann, H.
1986
Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance.
Nature 323, 164-166.
Goldman, J.M., Waldmann, H. et al
1986
Bone marrow transplantation for patients with chronic myeloid leukemia.
New Eng. J. Med. 314, 202-207.
Hale, G. & Waldmann, H.
1986
Depletion of T Cells with CAMPATH-1 and Human Complement. Analysis of GVHD and Graft Failure in a Multi-centre Study.
Bone Marrow Transplantation 1 Suppl. 1, 93.
Hale, G., Edwards, J.C. & Waldmann, H.
1986
Prevention of graft-versus-host disease by T cell depletion with CAMPATH-1. Overview of results using antibody produced in Cambridge.
Bone Marrow Transplantation in Malignant Disease (Ed. Edwards, C. & Nethersall, A. Pub Wellcome, 37-46.
Hale, G., Waldmann, H., Friend, P. & Calne, R.
1986
Pilot study of CAMPATH-1, a rat monoclonal antibody that fixes human complement, as an immunosuppressant in organ transplantation.
Transplantation 42, 308-310.
Heit, W., Bunjes, D., Wiesneth, M., Schmeiser, T., Arnold, R., Hale, G., Waldmann, H. & Heimpel, H.
1986
Ex vivo T-cell depletion with the monoclonal antibody CAMPATH-1 plus human complement effectively prevents acute graft-versus-host-disease in allogeneic bone marrow transplantation.
Brit. J. Haematol. 64, 479-486.
Muller, S., Cobbold, S., Waldmann, H. & Kauffman, S.H.E.
1986
Role of T lymphocytes in protection against mycobacterium tuberculosis.
Immunobiology 173, 415.
Or, R., Cividalli, G., Brautbar, C., Weiss, L., Weschler, Z., Samuel, S., Hale, G., Waldmann, H., Rachmilewitz, E.A. & Slavin, S.
1986
Bone Marrow Transplantation in beta-thalassemia major (TM) using T-cell depleted HLA-identical bone marrow allografts.
Bone Marrow Transplantation 1, Suppl. 337.
Slavin, S., Hale, G., Waldmann, H. et al
1986
New approaches for the prevention of rejection and graft-versus-host disease in clinical bone marrow transplantation.
Israel J. Medical Sciences 22, 264-267.
Slavin, S., Naparstek, E., Cividalli, G., Weshler, Z., Weiss, L., Mumchoglu, M., Brautbar, C., Schlesinger, M., Hale, G., Waldmann, H. & Or, R.
1986
The use of CAMPATH-1 for prevention of graft-vs-host disease (GVHD) and total lymphoid irradiation (TLI) for abrogation of host resistance to T-cell depleted allografts.
UCLA Symposia.
Slavin, S., Or, R., Weshler, Z., Hale, G. & Waldmann, H.
1986
The use of total lymphoid irradiation for abrogation of host resistance to T-cell depleted marrow allografts .
Bone Marrow Transplantation 1, Suppl. 1, 98.
Waldmann H., Cobbold, S.
1986
Bone Marrow Transplantation in Malignant Disease (Ed. Edwards, C. & Nethersall, A.).
Monoclonal antibodies and bone marrow transplantation. Pub. Wellcome, 29-36.
Wilson, A.B., Harris, J., Waldmann, H. & Coombs, R.R.A.
1986
Direct antibody rosette forming reactions using monoclonal markers of lymphocyte subpopulations: methodology and applications illustrated by investigations with rat pan-T antibodies of the CAMPATH series.
J. Immunol. Methods. 92, 241-249.
Aqel, N.M., Ball, R.Y., Waldmann, H. & Mitchinson, M.J.
1985
Identification of macrophages and smooth muscle cells in human atherosclerosis using monoclonal antibodies.
J. Path.. 146, 197-204.
Bindon, C.I., Hale, G., Clark, M.R. & Waldmann, H.
1985
Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen: synergy and interference in complement-mediated lysis1.
Transplantation 40, 538-544.
Cobbold, S.P. & Waldmann, H.
1985
Skin Allograft Rejection by L3/T4+ and Lyt-2+ T Cell subsets.
Transplantation 41, 634-639.
Hale, G. & Waldmann, H.
1985
Human Complement Fixing Antibodies in Transplantation.
In: Hybridoma technology in the biosciences and medicine. Ed. Springer, T. Plenum Press.
Hale, G. Clark, M.R. & Waldmann, H.
1985
Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.
J. Immunol. 134, 3056-3061.
Hale, G., Swirsky, D., Waldmann, H. & Chan, L.C.
1985
Reactivity of rat monoclonal antibody CAMPATH-1 with human leukaemia cells and its possible application for autologous bone marrow transplantation.
Brit. J. Haematol. 60, 41-48.
Morgan, G., Linch, D.C., Knott, L.T., Davies, E.G., Sieff, C., Chessells, J.M., Hale, G., Waldmann, H. & Levinsky, R.J.
1985
Successful haploidentical mismathced bone marrow transplantation in severe combined immunodeficiency: T-cell removal using CAMPATH-1 monoclonal antibody and E-rosetting.
Brit. J. Haematol.. 62, 421-430.
Slavin, S., Waldmann, H., Or, R. et al
1985
Prevention of Graft-versus-Host disease in Allogeneic Bone Marrow Transplantation for Leukaemia by T Cell Depletion in vitro Prior to Transplantation.
Transpl. Proc. 17, 465-467.
Thierfelder, S., Cobbold, S.P., Kummer, U., Waldmann, H. & Schuh, R.
1985
Antilymphocyte Antibodies and Marrow Transplantation. VII. Two out of Nine Monoclonal Anti-Thy 1 Antibodies Used for Pretreatment of Donor Marrow Suppressed Graft-versus-Host Reactions Without Added Complement.
Exper. Haematol. 13, 948-955.
Watt, S.M., Gilmore, D.J., Clark, M.R., Davis, J.M., Swirsky, D.M. & Waldmann, H.
1985
Haemopoietic Progenitor Cell Heterogeneity Revealed by a Single Monoclonal Antibody, YW 13.1.1.
Mol. Biol. Med. 2, 351-368.
Aqel, N.M., Ball, R.Y., Waldmann, H. & Mitchinson, M.J.
1984
Monocytic Origin of Foam Cells in Human Atherosclerotic Plaques.
Atherosclerosis 53, 265-271.
Aqel, N.M., Clark, M.R., Cobbold, S.P. & Waldmann, H.
1984
Immunohistological Screening in the Selection of Monoclonal Antibodies: the Use of Isotype-Specific Antiglobulins.
J. Immunol. Methods 69, 207-214.
Bindon, C., Hale, G. & Waldmann, H.
1984
Therapeutic potential of monoclonal antibodies to the leucocyte common antigen.
8th International Conference on Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Plenum.
Clark, M.R., Cobbold, S.P., Waldmann, H. & Coombs, R.R.A.
1984
Detection of Monoclonal Antibodies Against Cell Surface Antigens: the Use of Antiglobulins Coupled to Red Blood Cells.
J. Immunol. Methods 66, 81-87.
Clark, M.R., Hale, G. & Waldmann, H.
1984
Interaction of rat monoclonal antibodies with human killer cells.
8th International Conference on Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Planum.
Cobbold, S.P. & Waldmann, H.
1984
Therapeutic potential of monovalent monoclonal antibodies.
Nature 308, 460-462.
Cobbold, S.P., Jayasuriya, A., Nash, A., Prospero, T.D. & Waldmann, H.
1984
Therapy with monoclonal antibodies. Elimination of T-cell subsets in vivo.
Nature 312, 548-551.
Cobbold, S.P., Martin, G., Lovat, P.E. & Waldmann, H.
1984
Immunosuppression with monoclonal antibodies - rules for effective serotherapy.
8th International Conference on Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Plenum.
Hale, G., Hoang, T., Prospero, T., Watt, S.M. & Waldmann, H.
1984
Removal of T-cells from bone marrow for transplantation.
Mol. Biol. Med. 1, 305-319.
Lefkovits, I. & Waldmann, H.
1984
Limiting dilution analysis of the cells of immune system. I. The clonal basis of the immune response.
Immunology Today 5, 265-268.
Levinsky, R.J., Morgan, D., Davies E.G., Waldmann, H. et al
1984
Mismatched bone marrow transplantation for severe combined immunodeficiency - The Great Ormond Street Experience. Ed. Griscelli, C. & Vossen,
J. Excerpta Medica 393-399.
Matzinger, P., Zamoyska, R. & Waldmann, H.
1984
Self tolerance is H-2 restricted.
Nature 308, 738-741.
Slavin, S., Or, R., Waldmann, H. et al
1984
Elimination of graft versus host disease in matched allogeneic leukaemic transplant recipients using CAMPATH-1.
8th International Conference on Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Plenum.
Sullivan, C., Kenny, G. & Waldmann, H.
1984
The role of the major histocompatibility complex in in vitro antibody responses; MHC restriction in responses involving linked recognition of antigenic determinants is not solely consequent to T-cell accessory cell restrictions.
Immunology 51, 351-360.
Sullivan, C.P. & Waldmann, H.
1984
T-cell help mechanisms in the in vitro antibody response: the role of linked and non-linked recognition interactions.
Immunology 51, 343-350.
Waldmann, H. & Lefkovits, I.
1984
Limiting dilution analysis of cells of the immune system II: What can be learnt?
Immunology Today 5, 295-298.
Waldmann, H., Cobbold, S.P., Wilson, A.B. Clark, M.R., Watt, S., Hale, G. & Tighe H.
1984
Rat monoclonal antibodies for bone marrow transplantation -the CAMPATH series.
8th International Conference of Lymphatic Tissues & Germinal Centres. Klaus, GG. Ed. Plenum.
Waldmann, H., Or R., Hale, G., Weiss, L. et al
1984
Elimination of graft-versus-host disease by in vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1).
Lancet II, 483-486.
Zamoyska, R. & Waldmann H.
1984
Allosuppression: evidence for the involvement of both 'noncytotoxic' and cytotoxic T cells.
Europ. J. Immunol. 14, 645-651.
Cobbold, S.P., Thierfelder, S. & Waldmann, H.
1983
Immunosuppression with Monoclonal Antibodies: A Model to Determine the Rules for Effective Serotherapy.
Mol. Biol. Med. 1, 285-304.
Downie, D.M., Voak, D., Jarvis, J., Waldmann, H. & Spitz, M.
1983
The Use of Monoclonal Antibodies in Human IgG in Blood Transfusion Serology.
Bio. Bull.. 4, 348-352.
Hale, G., Bright, S., Chumbley, G., Hoang, T.K. Metcalf, D., Munro, A.J. & Waldmann, H.
1983
Removal of T Cells from Bone Marrow for Transplantation: A Monoclonal Antilymphocyte Antibody that Fixes Human Complement.
Blood 62, 873-882.
Hale, G., Swirsky, D.M., Hayhoe, F.G.J. & Waldmann, H.
1983
Effects of Monoclonal Anti-lymphocyte Antibodies in in vivo Monkeys and Humans.
Mol. Biol. Med. 1, 321-334.
Hoang, T., Gilmore, D., Metcalf, D., Cobbold, S.P., Watt, S., Clark, M., Furth, M. & Waldmann, H.
1983
Separation of Haemopoietic Cells from Adult Mouse Marrow by use of Monoclonal Antibodies.
Blood 61, 580-588.
Swirsky, D.M., Watt, S.M., Gilmore, D.J., Hayhoe, F.G.J. & Waldmann, H.
1983
The Characterisation of Monoclonal Antibodies Against Haemopoietic cells: Comparison of an Immunoperoxidase Method with Fluorescence Activated Cell Sorting.
J. Immunol. Methods 61, 171-182.
Watt, S.M., Metcalf, D., Gilmore, D.J., Stenning, G.M., Clark, M.R. & Waldmann, H.
1983
Selective Isolation of Murine Erythropoietin-responsive Progenitor Cells (CFU-E) with Monoclonal Antibodies.
Mol. Biol. Med. 1, 95-115.
Zamoyska, R., Waldmann, H. Prospero, T. & Lennox, E.
1983
Identification of Phenotypically Distinct Subpopulations of Cytotoxic T Lymphocytes.
Mol. Biol. Med. 1, 137-150.
Waldmann, H. & Milstein, C.
1982
Monoclonal antibodies I
in Clinical Aspects of Immunology. Eds. Lachmann, P.S. & Peters, K. Blackwell.
Waldmann, H., Munro, A.J. & Maurer, P.
1982
The Thymus and its Influence on the Expression of Immune Response Genes.
Behring Institute Mitteilungen No. 70, 167-172.
Watt, S.M., Gilmore, D.J., Metcalf, D., Cobbold, S.P., Hoang, T.K. & Waldmann, H.
1982
Segregation of Mouse Hemopoietic Progenitor Cells Using the Monoclonal Antibody, YBM/42.
J. Cell Physiol 115, 37-45.
Cobbold, S.P. & Waldmann, H.
1981
A rapid solid-phase enzyme-linked binding assay for screening monoclonal antibodies to cell surface antigens.
J. Immunol. Methods 44, 125-133.
McConnell, I., Munro, A.J. & Waldmann, H.
1981
The Immune System (A textbook of immunology).
Blackwell.
Desaymard, C., Shinton, R.A. & Waldmann, H.
1980
Differences in calcium requirements for B-cell tolerance and immunity.
Immunology 39, 61-65.
Takei, F., Waldmann, H. Lennox, E.S. & Milstein, C.S.
1980
Monoclonal antibody H9/25 reacts with functional subsets of T and B cells: killer, killer precursor and plaque-forming cells.
Europ. J. Immunol. 10, 503-509.
Waldmann, H. & Phillips, J.
1980
How Many T Cells Help One B Cell?
Springer Seminars in Immunopathology 3, 129-144.
Waldmann, H.
1979
Interactions between T and B cells: a review.
Journal of Roy. Soc. Med. 72, 198-202.
Waldmann, H. & Lefkovits, I.
1979
Limiting dilution analysis of cells in the immune system.
(monograph) Cambridge University Press,
Waldmann, H., Kenny, G., Brown, D. & Feinstein, A.
1979
Restrictions in the helper activity of T-cells.
Proc. of the 12th Leukocyte Culture Conference 'Biochemistry and cell biology of leukocyte functions'. Ed. Mr. Quastel. Acad. Press, 403.
Waldmann, H., Munro, A.J. & Maurer, P.H.
1979
The Role of MHC Gene Products in the Development of the T-cell Repertoire.
In Immunobiology of the Bone Marrow Transplantation, Vol. 25. Eds. Thierfelder, S., Rodt, H. & Kolb, H.J. Suppl. Haematology and Blood Transfusion. BLIT.
Waldmann, H., Pope, H., Bettles, C. & Davies, A.J.S.
1979
The influence of thymus on development of MHC restrictions exhibited by T-helper cells.
Nature 277, 137-138.
Munro, A.J. & Waldmann, H.
1978
The Major Histocompatibility System and the Immune Response.
Brit. Med. Bull. 34, 253-258.
Waldmann, H.
1978
The Influence of the Major Histocompatibility Complex on the Function of T-helper Cells in Antibody Formation.
Immunological Rev. 42, 202-223.
Waldmann, H. & Howard, J.C.
1978
Ed. Lennox, E.
In: Defence and Recognition, chapter entitled Cellular Basis of the Immune Response.
Waldmann, H., Pope, H., Brent, L. & Bighouse, K.
1978
The influence of the major histocompatibility complex on lymphocyte interactions in antibody formation.
Nature 274, 166-168.
Lefkovits, I. & Waldmann, H.
1977
B Cell Subsets in Nude Mice.
Immunology 32, 915.
Phillips, J. & Waldmann, H.
1977
The monogamous T-helper cell.
Nature 268, 641-642.
Waldmann, H.
1977
Conditions Determining the Generation and Expression of T Helper Cells.
Immunological Rev. 35, 121-145.
Waldmann, H. & Pope, H.
1977
The influence of antigen presentation on the generation of T-helper cells with different functions.
Immunology 33, 721-725.
Waldmann, H. & Pope, H.
1977
Can B-cell tolerance be induced by oligovalent thymus dependent antigens?
Immunology 32, 657-667
Waldmann, H., Pope, H. & Kenny, G.
1977
Co-operation across histocompatibility differences: The role of inhibitory T cells in preventing successful T-B interaction.
Immunology 33, 129-139.
Desaymard, C. & Waldmann, H.
1976
Evidence for the inactivation of precursor B-cells in high dose unresponsiveness.
Nature 264, 780-782.
Waldmann, H.
1976
Breaking tolerance to self molecules' in
physiological effects of immunity against reproductive hormones. Eds. Edwards, R.G. & Johnson, M.H., Cambridge University Press, P.5-22.
Waldmann, H. Pope, H. & Lefkovits, I.
1976
Limiting dilution analysis of helper T-cell function: II. An approach to the study of the function of single helper T-cells.
Immunology 31, 343-352.
Waldmann, H., Lefkovits, I. & Feinstein, A.
1976
Restriction in the functions of single helper T cells.
Immunology 31, 353-362.
Waldmann, H., Pope, H. & Munro, A.J.
1976
Cooperation across the histocompatibility barrier, H-2d T-cells primed to antigen in an H-2d environment can cooperate with H-2k B cells.
J. Exp. Med. 144, 1707-1711.
Waldmann, H., Poulton, P. & Desaymard, C.
1976
Antigen-non-specific T-cell factor in B-cell activation: Origin, biological properties and failure to show a relationship to H-2.
Immunology 30, 723-733.
Lefkovits, I., Quintans, J., Munro, A. & Waldmann,, H.
1975
T Cell-dependent Mediator and B-cell Clones.
Immunology 28, 1149-1154.
Slowe, A. & Waldmann, H.
1975
The 'Intrinsic Adjuvanticity' and Immunogenicity of Trinitrophenylated Lipopolysaccharide.
Immunology 29, 825-834.
Waldmann, H.
1975
T Cell-dependent Mediator in the Immune Response: III. The role of non-specific factor (NSF) in the in vitro immune response.
Immunology 28, 497-507.
Waldmann, H. & Lachmann, P.J.
1975
The failure to show a necessary role for C3 in the in vitro antibody response.
Europ. J. Immunol. 5, 185-193.
Waldmann, H. & Munro, A.J.
1975
B Cell Activation.
Transplant.Rev. 23, 213-222.
Waldmann, H. & Munro, A.J.
1975
The Inter-relationship of Antigenic Structure, Thymus-Independence and Adjuvanticity: IV. A 'general model for B-cell induction'.
Immunology 28, 509--522.
Waldmann, H., & Pope, H.
1975
Low dose unresponsiveness with a thymus independent antigen.
Nature 258, 730-731.
Waldmann, H., Lefkovits, I. & Quintans, J.
1975
Limiting Dilution Analyses of Helper T-cell Function.
Immunology 28, 1135-1147.
Waldmann, H., Pope, H. & Munro, A.J.
1975
Cooperation across the histocompatibility barrier.
Nature 258, 728-730.
Waldmann, H. & Munro, A.J.
1974
T-cell dependent mediator in the immune response. II. Physical and biological properties.
Immunology 27, 53-64.
Waldmann, H. & Munro, A.J.
1974
T-cell dependence of B-cell unresponsiveness in vitro.
Europ. J. Immunol. 4, 410-416.
Waldmann, H. & Munro, A.J.
1973
T-cell Dependent Mediator in the Immune Response.
Nature 243, 356-357.
Waldmann, H., Munro, A.J. & Hunter, P.
1973
Properties of educated T-cells. The ability of educated T-cells to facilitate the immune response to non-cross reacting antigens in vitro.
Europ. J. Immunol. 3, 167-172.

Last updated 17th November 2015