Duncan Howie’s
Publications:
Howie, D., Nolan, KF., Daley, S., Butterfield, E.,
Cobbold SP, Adams E, Farquhar CA, Nolan KF, Howie D, Lui KO, Fairchild PJ, Mellor AL, Ron D & Waldmann H. Infectious tolerance via the consumption of essential amino acids and mTOR signalling. Proc Natl Acad Sci U S A, in press (2009)
Howie D, Laroux FS, Morra M, Satoskar AR, Rosas LE, Faubion WA, Julien A,
Rietdijk S, Coyle AJ, Fraser C, Terhorst C. Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J Immunol. 2005 May 15;174(10):5931-5.
Graca L, Chen TC,
Le Moine A, Cobbold SP, Howie D, Waldmann H.
Dominant tolerance: activation thresholds for peripheral generation of
regulatory T cells. Trends Immunol. 2005;26(3):130-5
Nanda
N, Andre P, Bao M, Clauser
K, Deguzman F, Howie D, Conley PB, Terhorst C, Phillips DR. Platelet
aggregation induces platelet aggregate stability via SLAM family receptor
signaling. Blood.
2005;106(9):3028-34.
Okamoto S, Ji H, Howie D, Clarke K, Gullo C, Manning S, Coyle AJ, TerhorstC. Expression of the SH2D1A gene is regulated by a combination of transcriptional and post-transcriptional mechanisms. Eur J Immunol. 2004 Nov;34(11):3176-86. Wang N, Satoskar A, Faubion W, Howie D, Okamoto S, Feske S, Gullo C, ClarkeK, Sosa MR, Sharpe AH, Terhorst C. The cell surface receptor SLAM controls T cell and macrophage functions.J Exp Med. 2004 May 3;199(9):1255-64.
Simarro M, Lanyi A, Howie D, Poy F, Bruggeman J, Choi M, Sumegi J, Eck MJ,
Terhorst C. SAP increases FynT kinase activity and is required for phosphorylation of SLAM
and Ly9.Int Immunol. 2004 May;16(5):727-36.
Roda-Navarro
P, Mittelbrunn M, Ortega M, Howie D, Terhorst C, Sánchez-Madrid F, Fernández-Ruiz E. Dynamic
redistribution of the activating 2B4/SAP complex at the cytotoxic
NK cell immune synapse. J Immunol. 2004;173(6):3640-6.
Howie D, Spencer J, DeLord D, Pitzalis C,
Howie D, Sayos J, Guirado M, Simarro M, Sancho J and Terhorst C. Molecular dissection of the signaling and co-stimulatory functions of CD150 (SLAM). Blood 2002; 99(3):957-65.
Howie D, Okamoto S, Rietdijk S, Clarke K, Wang N, Gullo C, Bruggeman JP, Manning S, Coyle AJ, Greenfield E, Kuchroo V and Terhorst C. The role of SAP in murine CD150 (SLAM)-mediated T cell proliferation and Interferon gamma production. Blood 2002;100(8):2899-2907
Howie D, MacDonald TT. The ontogeny of T lymphocytes within the human intestine.
Sanderson IR, Walker WA (eds:
Development of the Gastrointestinal tract.
Howie D, Sayos J, Terhorst C, Morra M. The gene defective in X-linked lymphoproliferative disease controls T cell dependent immune surveillance against Epstein-Barr virus. Curr Opin Immunol 2000; 12:474-478.
Sandilands GP, Howie D, and Macsween RNM. Occult expression of CD32 (FcgRII) in normal human peripheral blood mononuclear cells. Immunology
1995; 86:525-532.
Pender SLF, Tickle SP, Doherty
AJP, Howie D,
DeLord D, Wahid S, Howie D, Scott DL, Panayi GS, MacDonald TT, et al. Morphology of fetal gut tissue transplanted into SCID mice. Arthritis and Rheumatism 1998; 41:962.
Pender SLF, Breese EJ, Ute G, Howie D, Wathen NC, Schuppan D and MacDonald TT. Suppression of T cell mediated injury in human gut by interleukin-10: Role of matrix metalloproteins. Gastroenterology 1998; 115:573-583.
Sayos
J, Nguyen KB, Wu C, Stepp SE, Howie D, Schatzle JD, et al. Potential pathways for regulation of NK
and T cell responses: differential X-linked lymphoproliferative
syndrome gene product. Int
Immunol 2000;
12:1749-1757.
Morra M, Howie D, Grande MS, Sayos J, Wang N, Wu C, et al. X-linked lymphoproliferative disease; a progressive immunodeficiency. Annual Rev. Immunol 2001; 19:657-682.
Sayos
J, Martin M, Chen A, Simarro M, Howie D, Morra M, et al. Cell surface receptors Ly-9 and CD84
recruit the XLP gene Product SAP. Blood 2001;
97:3867-74.
Wang N, Morra M, Wu C, Gullo C, Howie D, Coyle T, et al. CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells. Immunogenetics 2001; 53:382-394.
Wu C, Sayos J, Wang N, Howie D, Coyle A and Terhorst C. Genomic organization and characterization of murine SAP: the gene coding for X-linked lymphoproliferative disease. Immunogenetics 2001; 51:805-815.
Wu C, Nguyen KB, Pien GC, Wang N, Gullo C, Howie D, et al. SAP controls T cell responses to virus and terminal differentiation of TH2 cells. Nat Immunol 2001; 2:410-414.
Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe M, Engel P, Eck M and Terhorst C. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J 2001; 20:5840-52.
Frazer CC, Howie D, Morra M, Qiu Y, Murphy C, Shen Q, Gutierrez-Ramos J, Coyle A, Kingsbury G and Terhorst C. Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family. Immunogenetics 2002; 53:843-50.
Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ. SAP couples
Faubion WA, Howie D, Abadia-Molina A, et al. Monoclonal
antibody to signaling lymphocyte activation molecule (SLAM) improves disease
severity in a mouse model of experimental colitis
Gastroenterology 122 (4): T949 Suppl. 1 APR 2002.
Morra M, Lu J, Poy F, et al.The Free-SH2 domain EAT-2 binds SLAM related receptors in
hematopoeitic cells. FASEB J 16 (4): A321-A321 Part 1 MAR 20 2002