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Nigel Saunders academic publications:

Where possible, we prefer to publish in Open Access Journals. Links go directly to Free and Open Access Articles, otherwise to NCBI.

[C= ] indicates the number of citations for each paper as of January 2007.

Broadly, papers since 2001 are attributable to the Dunn School of Pathology / the BPFG as an independent research group. Papers from 1998 to 2000 are attributable to work done as a Wellcome Trust Fellow as a member of Richard Moxon's group at the Institute of Molecular Medicine, Oxford. Papers from 1994 to 1995 are attributable to work done as a Registrar at the RPMS / Hammersmith Hospital, whilst working under the supervision of Jon Cohen and Tom Rogers. Previous papers were based upon work done as an undergraduate under the supervision of John Simpson and Paul Whiting.

2007:

1.        Neisseria: a post-genomic view. Lori AS Snyder, Philip Jordan and Nigel J Saunders. In: Pallen, MJ., Nelson, K. and Preston G (Editors). Bacterial Pathogenomics. ASM Press, Washington, DC – in press, publication date August. (Book chapter)

2.        Protein Microarrays. Nigel J Saunders. In: Falciani, F (Editor). Microarray Technology Through Applications. Taylor and Francis. – in press, publication date April. (Book chapter)

3.        Comparative Genomics – the use of probability scores and Bayesian modelling in CGH. Lori AS Snyder, Graham Snudden, Nick Haan, and Nigel J Saunders. In: Falciani, F (Editor). Microarray Technology Through Applications. Taylor and Francis. – in press, publication date April. (Book chapter)

4.        Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression. Ashraf Malhas, Chiu Fan Lee, Rebecca Sanders, Nigel J Saunders and David J Vaux. Journal of Cell Biology 176: 593-603.

5.        Comparative genomic view of mechanisms of variation in Neisseria meningitidis, revealed through sequencing and analysis of a third meningococcal genome from serogroup C strain FAM18. Stephen D Bentley, George S Vernikos, Lori AS Snyder, Claire Arrowsmith, Tracey Chillingworth, Anne Cronin, Paul Davis, Nancy Holroyd, Kay Jagels, Mark Maddison, Sharon Moule, Ester Rabbinowitsch, Sarah Sharp, Loise Unwin, Sally Whitehead, Michael A Quail, Carol Churcher, Mark Achtman, Bart Barrell, Nigel J Saunders and Julian Parkhill. PLoS Genetics 3: e23.

6.       The small FNR regulon of Neisseria gonorrhoeae: comparison with the larger E. coli FNR regulon and interaction with the NarQ-NarP regulon. Rebekah Whitehead, Tim W Overton, Lori AS Snyder, Harry Smith, Jeff A Cole and Nigel J Saunders. BMC Genomics 8: 35.

2006:

7.        Population-associated differences between the phase variable LPS biosynthetic genes of Helicobacter pylori. Laurence Salaün and Nigel J Saunders. BMC Microbiology 6: 79.

8.        Coordinated regulation of the Neisseria gonorrhoeae truncated denitrification pathway by the nitric oxide-sensitive repressor, NsrR, and nitrite-insensitive NarQ-NarP. Tim W Overton, Rebekah Whitehead, Ying Li, Lori AS Snyder, Nigel J Saunders, Harry Smith, and Jeff Cole. Journal of Biological Chemistry 281: 33115-33126.

9.        Comparison of the RpoH-dependent regulon and general stress response in Neisseria gonorrhoeae. Ishara C Gunesekere, Charlene M Kahler, Deiter Bulach, Lori AS Snyder, Nigel J Saunders, Julian I Rood and John K Davies. Journal of Bacteriology 188: 4769-4776. [C=1]

10.     Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85A resolution. Charlie Nichols, Sarah Sainsbury, Jingshan Ren, David Stammers, Nigel Saunders and Ray Owens. Acta Crystalographica F62: 494-497. [C=1]

11.     The majority of genes in the pathogenic Neisseria species are present in the non-pathogenic Neisseria lactamica, including those designated as ‘virulence genes’. Lori AS Snyder and Nigel J Saunders. BMC Genomics 7: 128. [C=3]

12.     Ecf, an alternative sigma factor from Neisseria gonorrhoeae controls expression of msrA/B, which encodes Methionine sulfoxide reductase. Ishara C Gunesekere, Charlene M Kahler, Catherine S Ryan, Lori AS Snyder, Nigel J Saunders, Julian I Rood and John K Davies. Journal of Bacteriology 188: 3463-3469.

2005:

13.     Complete and variant forms of the ‘Gonococcal Genetic Island’ in Neisseria meningitidis. Lori A S Snyder, Stephen A Jarvis, and Nigel J Saunders. Microbiology 151: 4005-4013. [C=4]

14.     Comparative overview of the differences between the pathogenic Neisseria strains and species. Lori A. S. Snyder, John K. Davies and Nigel J Saunders. Plasmid 54: 191-218. [C=1] (Review)

15.     Crystal structure of nitrogen regulatory protein IIANtr from Neisseria meningitidis. Jingshan Ren, Sarah Sainsbury, Nick Berrow, Dave Alderton, Joanne Nettleship, David K Stammers, Nigel J Saunders and Raymond J Owens. BMC Structural Biology 5: 13. [C=3]

16.     Genetic islands of Streptococcus agalactiae strains NEM316 and 2603VR and their presence in other Group B streptococcal strains. Mark A Herbert, Catherine JE Beveridge, David McCormick, E Aten, N Jones, Lori AS Snyder and Nigel J Saunders. BMC Microbiology (2005) 5: 31. [C=3]

17.     Strain-specific differences in Neisseria gonorrhoeae associated with the phase variable gene repertoire. Philip W Jordan, Lori AS Snyder and Nigel J Saunders. BMC Microbiology (2005) 5: 21. [C=1]

18.     The neisserial genomes: What they reveal about the diversity and behaviour of these species. Lori A. S. Snyder and Nigel J Saunders. In: The Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, (2005) John Wiley & Sons. (Book chapter)

19.     Analysis of leukocyte membrane protein interactions using protein microarrays. Michelle LeTarte, Despina Voulgaraki, Deborah Hatherley, Mildred Foster-Cuevas, Nigel J Saunders and A Neil Barclay. BMC Biochemistry (2005) 6: 2.

20.     Inter-species horizontal transfer resulting in core and niche-adaptive variation within H. pylori. Nigel J Saunders, Prawit Boonmee, John F Peden and Stephen A Jarvis. BMC Genomics (2005) 6: 9. [C=3]

21.     Phase variation mediated niche adaptation during prolonged experimental murine infection with Helicobacter pylori. Laurence Salaün, Sarah Ayraud and Nigel J Saunders.  Microbiology (2005) 151: 917-923. [C=5]

2004:

22.     Estimation of mutation rates. Mike B Gravenor and Nigel J Saunders. Biometrics (2004) 60: 1053-1054. (Correspondence)

23.     Bacterial virulence factors in neonatal sepsis: Group B streptococcus. Mark A Herbert, Catherine J E Beveridge and Nigel J Saunders. Current Opinion in Infectious Disease (2004) 17: 225-229. [C=4]

24.     The diversity within an expanded and re-defined repertoire of phase variable genes in Helicobacter pylori. Laurence Salaün, Bodo Linz, Sebastian Suerbaum, and Nigel J Saunders. Microbiology (2004) 150: 817-830. [C=18]

25.     Microarray genomotyping of key experimental strains of N. gonorrhoeae reveals gene complement diversity and five new neisserial genes associated with Minimal Mobile Elements. Lori A. S. Snyder, John K. Davies, and Nigel J. Saunders. BMC Genomics (2004) 5: 23. [C=8]

2003:

26.     Diversity in coding tandem repeats in related Neisseria spp. Philip Jordan, Lori A. S. Snyder, and Nigel J. Saunders. BMC Microbiology (2003) 3: article 23. [C=9]

27.     CD4+CD25+ TR cells suppress innate immune pathology by an IL-10-dependent mechanism. Kevin J. Maloy, Laurence Salaun, Rachel Cahill, Gordon Dougan, Nigel J. Saunders and Fiona Powrie. Journal of Experimental Medicine (2003) 197: 111-119. [C=208]

28.     Mutation rates: estimating phase variation rates when fitness differences are present and their impact on population structure. Nigel J Saunders, E. Richard Moxon and Mike Gravenor. Microbiology (2003) 149: 485-495. [C=15]

29.     Divergence and transcriptional analysis of the division cell wall (dcw) gene cluster in Neisseria spp. Lori A. S. Snyder, William M. Shafer and Nigel J. Saunders. Molecular Microbiology (2003) 47: 431-442. [C=6]

30.     Adaptation by phase variation in pathogenic bacteria. Lori A. S. Snyder, Laurence Salaün, and Nigel J. Saunders. Advances in Applied Microbiology (2003) 52: 263-301. [C=7] (Review)

31.     The use of complete genome sequences in vaccine design. Nigel J. Saunders and Sarah Butcher. In: Methods in Molecular Medicine: Vaccine Protocols 2nd Edition. Eds. A. Robinson, M. P. Cranage, and M. J. Hudson. Humana Press, Totowa, NJ  (2003) pp: 301-312. [C=1] (Book chapter)

32.     Evasion of antibody responses: Bacterial phase variation. Nigel J Saunders. In: Bacterial evasion of host immune responses. Eds: B Henderson and P Oyston. Cambridge University Press. (2003) pp: 103-124. [C=2] (Book chapter)

2002:

33.     The minimal mobile element. Nigel J. Saunders and Lori A. S. Snyder. Microbiology (2002) 148: 3756-3760. [C=8]

34.     Genome analysis and strain comparison of correia repeats and correia repeat-enclosed elements in pathogenic Neisseria. Shi V. Liu, Nigel J. Saunders, Alex C. Jeffries and Richard F. Rest. Journal of Bacteriology (2002) 184: 6163-6173. [C=14]

35.     Functional genomics of pathogenic bacteria. Moxon, E.R., Hood, D.W., Saunders, N.J., Schweda, E.K. and Richards, J.C. Philosophical Transactions of the Royal Society of London. B Biol Sci. (2002) 357: 109-116. [C=7] (Commentary / Review)

2001:

36.     Comparative whole genome analyses reveal over 100 putative phase variable genes in the pathogenic Neisseria spp. Lori A. S. Snyder, Sarah A. Butcher and Nigel J. Saunders. Microbiology­ (2001) 147: 2321-2332. [C=41]

37.     A putatively phase variable gene (dca) required for natural competence in Neisseria gonorrhoeae but not Neisseria meningitidis is located within the division cell wall (dcw) gene cluster. Lori A. Snyder, Nigel J. Saunders and William M. Shafer. Journal of Bacteriology (2001) 183: 1233-1241. [C=15]

 

Publications to this point are the product of work following the establishment of, and are attributable to, the Bacterial Pathogenesis and Functional Genomics Group, as an independent research group at the Sir William Dunn School of Pathology

 

38.     Genome sequencing and gene databases. Alex C Jeffries, Nigel J Saunders, Derek W Hood. In: Meningococcal Disease, Eds AJ Pollard and MCJ Maiden, Humana Press, Totowa, NJ (2001). (Book chapter)

2000:

39.     Repeat-associated phase variable genes in the complete genome sequence of Neisseria meningitidis strain MC58. Nigel J Saunders, Alex C Jeffries, John F Peden, Derek W Hood, Herve Tettelin, Rino Rappouli and E Richard Moxon. Molecular Microbiology (2000) 37: 207-215. [C=94]

40.     High rates of phase variation in Campylobacter jejuni? Nigel J Saunders, Alex C Jeffries, Derek W Hood and E Richard Moxon. Molecular Microbiology (2000) 36: 1054. [C=1]

41.     Absence of an uptake sequence in Helicobacter pylori – author’s reply. Nigel J Saunders, John F Peden and E. Richard Moxon. Microbiology (2000) 146: 1255-1256. (Correspondence / Authors reply)

42.     Working from the particular to the general – the development of comparative genomics. Nigel J Saunders. Molecular Microbiology (2000) 36: 1034-1036. (Review / Conference report)

43.     Genome Biology – a meeting report of the 4th microbial genomes meeting. Nigel J Saunders and Alex C Jeffries. Genome Biology (2000) 2000 1: reports 410.1-410.3 http://genomebiology.com/2000/1/1/reports/410/  (Conference report)

44.     Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Hervé Tettelin, Nigel J. Saunders, John Heidelberg, Alex C. Jeffries, Karen E. Nelson, Jonathan A. Eisen, Karen A. Ketchum, Derek W. Hood, John F. Peden, Robert J. Dodson, William C. Nelson, Michelle L. Gwinn, Robert DeBoy, Jeremy D. Peterson, Erin K. Hickey, Daniel H. Haft, Steven L. Salzberg, Owen White, Robert D. Fleischmann, Brian A. Dougherty, Tanya Mason, Anne Ciecko, Debbie S. Parksey, Eric Blair, Henry Cittone, Emily B. Clark, Matthew D. Cotton, Terry R. Utterback, Hoda Khouri, Haiying Qin, Jessica Vamathevan, John Gill, Vincenzo Scarlato, Vega Masignani, Mariagrazia Pizza, Guido Grandi, Li Sun, Hamilton O. Smith, Claire M. Fraser, E. Richard Moxon, Rino Rappuoli, and J. Craig Venter. Science (2000) 287: 1809-1815. [C=458]

45.     Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Mariagrazia Pizza, Vincenzo Scarlato, Vega Masignani, Marzia Monica Guiliani, Beatrice Arico, Lucia Baldi, Eroka Bartolini, Barbara Capecchi, Maurizio Comanducci, Cesira Galeotti, Gary T Jennings, Enico Luzzo, Roberto Manetti, Elisa Marchetti, Marirosa Mora, Sandra Nuti, Giulio Ratti, Laura Santini, Silvana Savino, Maria Scarselli, Elisa Storni, Peijun Zuo, Michael Broeker, Erika Hundt, Bernard Knapp, Eric Blair, Tanya Mason, Herve Tettlelin, Derek W Hood, Alex C Jeffries, Nigel J Saunders, Dan Granoff, Craig Venter, E Richard Moxon, Guido Grandi and Rino Rappuoli. Science (2000) 287: 1816-1820. [C=271]

46.     The length of a tetranucleotide repeat tract in Haemophilus influenzae determines the phase variation rate of a gene with homology to type III DNA methyltransferases. Xavier de Bolle, Christopher D. Bayliss, Tamsin van de Ven, Nigel J Saunders, Derek W. Hood and E. Richard Moxon. Molecular Microbiology (2000) 35: 211-222 [C=52]

Pre-2000:

47.     Absence in Helicobacter pylori of an uptake sequence for enhancing uptake of homospecific DNA during transformation. Nigel J Saunders, John F Peden and E. Richard Moxon. Microbiology (1999) 145: 3523-3528. [C=14]

48.     Bacterial evolution: Bacteria play pass the gene. Nigel J Saunders, Derek Hood and E Richard Moxon. Current Biology (1999) R180-183. [C=12] (Commentary / Review)

49.     Implications of sequencing bacterial genomes for pathogenesis and vaccine development. Nigel J Saunders and E Richard Moxon. Current Opinion in Biotechnology (1998) 9: 618-623. [C=14] (Commentary / Review)

50.     An in silico evaluation of Tn916 as a tool for generalized mutagenesis in Haemophilus influenzae Rd. Sarah L Hosking, Mary E Deadman, E Richard Moxon, John F Peden, Nigel J Saunders and Nicola J High. Microbiology (1998) 144: 2525-2530. [C=1]

51.     Simple sequence repeats in the Helicobacter pylori genome. Nigel J Saunders, John F Peden, Derek W Hood and E Richard Moxon. Molecular Microbiology (1998) 27: 1091-1098. [C=112]

52.     Trough only monitoring of serum vancomycin concentrations in neonates. Fiona Shackley, Philip Roberts, Paul Heath, Ian Bowler and Nigel J Saunders. The Journal of Antimicrobial Chemotherapy (1998) 41: 141-142. [C=5]

53.     A prospective laboratory-based audit of gentamicin use and therapeutic monitoring. Nigel J Saunders, David J Adams and William A Lynn. The Journal of Antimicrobial Chemotherapy (1995) 36: 729-736. [C=5]

54.     A study of the interaction between recombinant bactericidal permeability increasing protein (rBPI23) and gentamicin. Nigel J Saunders and Jonathan Cohen. The International Journal of Antimicrobial Agents (1995) 5: 259-263. [C=1]

55.     Assay of vancomycin by fluorescence polarization immunoassay and EMIT in patients with renal failure. Nigel J Saunders, Susan V Want and David J Adams. The Journal of Antimicrobial Chemotherapy (1995) 36: 411-415. [C=8]

56.     Vancomycin administration and monitoring reappraisal. Nigel J Saunders. The Journal of Antimicrobial Chemotherapy (1995) 36: 279-282. [C=22] (Commentary / Review)

57.     The Spectrum of Hepatitis C Antibody Positive Disease in a Teaching Hospital. RF Esfahani, N. Saunders, KN Ward and HJF Hodgson. Journal of Infection (1995) 30: 115-119. [C=2]

58.     Why monitor peak vancomycin concentrations. Nigel J Saunders. The Lancet (1995) 345: 646-647. (Correspondence / authors reply)

59.     Why monitor peak vancomycin concentrations? Nigel J Saunders. The Lancet (1994) 344: 1748-1750. [C=47]

60.     The Effects of Cyclosporin A on Glucose Homeostasis and the Kidney in the Normal Rat. PH Whiting, KJ Thomson, NJ Saunders and JG Simpson. Journal of Experimental Pathology (1990) 71: 245-255. [C=9]

61.     Renal Structure and Function in Streptozotocin- Diabetic Rats Treated with Cyclosporin A. KJ Thomson, NJ Saunders, JG Simpson and PH Whiting. British Journal of Experimental Pathology (1989) 70: 405-414. [C=3]

62.     Cyclosporin A Nephrotoxicity in Streptozotocin-Diabetic Rats. PH Whiting, KJ Thomson, NJ Saunders and JG Simpson. Transplantation Proceedings (1989) 21 (1 part 1): 946 -947. [C=1]

63.     Chronic Renal Tubular Damage Caused by Cyclosporin A. PH Whiting, NJ Saunders, KJ Thomson and JG Simpson. In: Nephrotoxicity: extrapolation from in vitro to in vivo and from animals to man. Eds. Bach PH and Lock EA, Plenham Press 1989: 307-13. (Book chapter)

64.     Chronic Renal Damage Caused by Cyclosporin. JG Simpson, NJ Saunders, KJ Thomson and PH Whiting. Transplantation Proceedings (1988) 20 (suppl.3): 792-799. [C=14]