Click on the titles to open links to the papers on PubMed.

2017

Groh M, Albulescu LO, Cristini A, Gromak N. Senataxin: Genome guardian at the interface of transcription and neurodegeneration. J Mol Biol.

2016

Kotsantis K,  Silva LM, Irmscher S, Jones RM, Folkes L, Gromak N* & Petermann E* . Increased  global transcription activity as a mechanism of replication stress in cancer. Nature Comm.

2014

M.Groh, N.Gromak. Out of balance: R-loops in human disease. PLoS Genet.

M.Groh, L.M.Silva and N.Gromak. Mechanisms of transcriptional dysregulation in repeat expansion disorders. Biochemical Society Transactions

M.Groh, M.M.Lufino, R. Wade-Martins, N.Gromak. R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome. PLoS Genet.

2013

N.Gromak*, M. Dienstbier, S. Macias, M. Plass, E. Eyras, J.F.Caceres and N.J. Proudfoot*. Drosha regulates gene expression independently of RNA-cleavage function. Cell Reports.

2012

N.Gromak. Intronic microRNAs: a crossroad in gene regulation. Biochemical Society Transactions

2011

K.Skourti-Stathaki, N.J.Proudfoot* and N.Gromak*. Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Molecular Cell.

2009

C.J.Webby*, A.Wolf*, N.Gromak*, M.Dreger, H.Kramer, B.Kessler, M.L.Nielsen, C.Schmitz, D.S.Butler, J.R.Yates III, C.M.Delahunty, P.Hahn, A.Lengeling, M.Mann, N.J.Proudfoot, C.J.Schofield & A.Böttger. Jmjd6 catalyses Lysyl-hydroxylation of U2AF65 – a protein associated with RNA splicing. Science.

2008

M.Morlando,  M.Ballarino*, N.Gromak*, F.Pagano, I.Bozzoni, N.J.Proudfoot. Primary mi-RNA transcripts are processed co-transcriptionally. Nature Structural Molecular Biology.

N.Gromak, G.Talotti, N.J.Proudfoot, F.Pagani. Modulation of alternative splicing by co-transcriptional cleavage of nascent intronic RNA. RNA journal.

2006

N.Gromak, S.West, N.J.Proudfoot. Pause sites promote transcriptional termination of mammalian RNA Polymerase II. Mol Cell Biol.

M.J.Dye, N.Gromak, N.J.Proudfoot. Exon tethering in transcription by RNA polymerase II. Molecular Cell.

S.West, N.Gromak, C.Norbury, N.J.Proudfoot. Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells. Molecular Cell.

M.J.Dye, N.Gromak, D.Haussecker, S.West, N.J.Proudfoot. Turnover and function of noncoding Polymerase II transcripts. Cold Spring Harbour Symposia on Quantitative Biology.

2004

S.West*, N.Gromak*, N.J.Proudfoot. Human 5’-3’ exonuclease Xrn2 promotes transcriptional termination from co-transcriptional cleavage sites. Nature.

2003

N.Gromak, A.Rideau, J.Southby, A.D.Scadden, C.Gooding, S.Huttelmaier, R.H.Singer, C.W.J.Smith. The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing. EMBO Journal.

N.Gromak, A.J.Matlin, T.A.Cooper and C.W.J.Smith. Antagonistic regulation of α-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein. RNA journal.

2002

N.Gromak and C.W.J.Smith. Splicing silencer that regulates smooth muscle specific alternative splicing is active in multiple cell types. Nucleic Acids Research.