Dr. Natalia Gromak

Royal Society University Research Fellow, Sir William Dunn School of Pathology

Science Research Fellow, St John's College, University of Oxford

Regulation of RNA metabolism in health and disease


Our research focuses on understanding the mechanisms governing gene regulation in humans in health and disease conditions. We are investigating the molecular basis of neurodegenerative diseases, arising due to mutations in proteins, involved in transcription and RNA processing. To elucidate pathways, regulating RNA metabolism, we exploit gene-specific and whole-genome approaches.


Research Details

  1. -Gene expression in diseases with mutations in transcription  and RNA processing machinery

  2. -Molecular pathology of AOA2/ALS4 ataxias

  3. -Mechanisms of Friedreich’s ataxia and Fragile X syndrome

  4. -Function of RNA/DNA hybrids (R-loops) in gene regulation