Scientific fields

Cytoskeleton, flagellum and cell morphogenesis in Trypanosoma brucei and Leishmania sp.

Eukaryotic flagella and cilia are cellular projections built around a highly conserved microtubule axoneme. They have many important functions ranging from cell motility to movement of particles and fluids in the human body and detection of signals during development. This diversity of functions is reflected in the ever increasing spectrum of human pathologies (collectively referred to as ciliopathies) associated with disruption of cilia and flagella....... >>

Genome evolution, expression and nuclear architecture

The nuclear genome of Trypanosoma brucei has an unusual gene organisation that reflects both its evolutionary divergence from many other model systems and also its parasitic lifestyle. The karyotype can be divided into 3 chromosomal classes: the megabase chromosomes, intermediate chromosomes and minichromosomes (Ersfeld and Gull, 1999). The megabase chromosomes are diploid and consist of 11 homologous pairs.... >>

Proteins and pathogenicity features of Trypanosomes

Under Construction