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The Divinity School, Oxford |
Recent PublicationsPeer reviewed papers in primary
research journals, invited reviews and book chapters resulting from the work
of my group and my postdoctoral research career are listed here. Last updated 8 October 2007 |
2007
Cell-type-specific expression of the human
CD68 gene is associated with changes in Pol II phosphorylation and short-range
intrachromosomal gene looping.
Genomics.
2007 Sep;90(3):407-15.
Increased
in-stent stenosis in ApoE knockout mice: insights from a novel mouse model of
balloon angioplasty and stenting.
Arterioscler
Thromb Vasc Biol. 2007 Apr;27(4):833-40.
2006
Liddiard K, Welch JS,
Lozach J, Heinz S, Glass CK, Greaves DR.
Interleukin-4 induction of the CC chemokine
TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the
TARC gene promoter.
BMC
Mol Biol. 2006 Nov 29;7:45.
Bursill CA, Cash JL,
Channon KM, Greaves DR.
Membrane-bound
CC chemokine inhibitor 35K provides localized inhibition of CC chemokine
activity in vitro and in vivo.
J
Immunol. 2006 Oct 15;177(8):5567-73.
MafB
is essential for renal development and F4/80 expression in macrophages.
Mol
Cell Biol. 2006 Aug;26(15):5715-27.
Oxidative
metabolism and PGC-1beta attenuate macrophage-mediated inflammation.
Cell
Metab. 2006 Jul;4(1):13-24.
Novel
candidate genes in unstable areas of human atherosclerotic plaques.
Arterioscler
Thromb Vasc Biol. 2006 Aug;26(8):1837-44.
Ali ZA, Bursill CA, Hu Y, Choudhury RP, Xu Q, Greaves
DR, Channon KM.
Gene transfer of a broad spectrum CC-chemokine
inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice.
Circulation. 2005; 112(9 Suppl):I235-241.
John AE, Channon KM and Greaves DR
Chemokines, chemokine receptors and atherosclerosis
In Chemokines, Chemokine Receptors and Disease,
Editor Lisa Schwiebert
Current Topics in Membranes, Volume 55, Elsevier
Academic Press
Gavin AL, Duong B, Skog P, Ait-Azzouzene D, Greaves
DR, Scott ML,
Nemazee D.
deltaBAFF, a splice isoform of BAFF, opposes
full-length BAFF activity in vivo in transgenic mouse models.
J Immunol. 2005; 175: 319-328.
Puhakka HL, Turunen P, Gruchala M, Bursill C, Heikura
T, Vajanto I, Greaves DR, Channon K,
Yla-Herttuala S.
Effects of vaccinia virus anti-inflammatory protein
35K and TIMP-1 gene transfers on vein graft stenosis.
In Vivo. 2005; 19: 515-521.
Levitin F, Baruch A, Weiss M,
Stiegman K, Hartmann ML, Yoeli-Lerner M, Ziv R, Zrihan-Licht S, Shina S, Gat A,
Lifschitz B, Simha M, Stadler Y,
Cholostoy A, Gil B, Greaves
DR, Keydar I, Zaretsky J,
Smorodinsky N, Wreschner DH.
A novel protein derived from the MUC1 gene by
alternative splicing and frameshifting.
J Biol Chem. 2005; 280: 10655-10663.
Gu JM, Johns A, Morser J, Dole WP, Greaves DR, Deng GG.
Urokinase plasminogen activator receptor promotes
macrophage infiltration into the vascular wall of ApoE deficient mice.
J Cell Physiol. 2005; 204: 73-82.
Greaves DR,
Gordon S.
Thematic review series: Recent insights into the biology of macrophage
scavenger receptors.
J Lipid Res. 2005; 46:11-20.
Bursill CA, Choudhury
RP, Ali Z, Greaves DR, Channon KM.
Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage
recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout
mice.
Circulation. 2004;110: 2460-2466.
O'Reilly D, Addley M,
Quinn C, MacFarlane AJ, Gordon S, McKnight AJ, Greaves DR.
Functional analysis of the murine Emr1 promoter identifies a novel purine-rich
regulatory motif required for high-level gene expression in macrophages.
Genomics. 2004; 84:1030-1040.
Bursill C, Channon KM, and Greaves DR
The role of chemokines in atherosclerosis: recent evidence from experimental
models and population genetics.
Current Opinion in Lipidology 2004, 15:
145 149.
Jalkanen J,
Leppanen P, Pajusola K, Narvanen O, Mahonen A, Vahakangas E, Greaves DR,
Bueler H, Yla-Herttuala S.
Adeno-associated virus-mediated gene transfer of a secreted decoy human
macrophage scavenger receptor reduces atherosclerotic lesion formation in
LDLreceptor knockout mice.
Mol Ther. 2003; 8: 903-910.
Lucas AD*,
Bursill CA*, Guzik TJ, Sadowski J, Channon KM and Greaves DR
Smooth muscle cells in human atherosclerotic plaques express the fractalkine
receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine
(CX3CL1).
Circulation, 2003; 108: 2498-2504.
Greaves
DR and Gordon S
Macrophage-specific gene targeting in vivo
In Pharmacology of the Macrophage, Siamon Gordon Editor,
Springer-Verlag, 2003
Jalkanen J, Leppanen P,
Narvanen O, Greaves DR, Yla-Herttuala S.
Adenovirus-mediated gene transfer of a secreted decoy human macrophage
scavenger receptor (SR-AI) in LDL receptor knock-out mice.
Atherosclerosis. 2003; 169: 95-103.
O' Reilly D, Quinn CM,
El-Shanaway T, Gordon S, and Greaves DR
Multiple Ets factors and interferon regulatory factor-4 (IRF-4) modulate CD68
expression in a cell type specific manner.
J. Biol. Chem, 2003; 278: 21909-19.
Bursill CA,
Cai S, Channon KM and Greaves DR
Adenoviral-mediated delivery of a viral chemokine binding protein blocks
CC-chemokine activity in vitro and in vivo.
Immunobiology, 2003 207: 187-196.
Welch JS,
Escoubet-Lozach L, Sykes DB, Liddiard K, Greaves DR and
Glass CK.
TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a
STAT6-dependent mechanism.
J Biol Chem. 2002; 277: 42821-42829
Greaves
DR, and Channon KM
Inflammation and immune responses in atherosclerosis
Trends in Immunology, 2002; 23: 535-541.
Greaves
DR
Meeting Report on 6th John Humphrey Advanced Summer School Programme in
Immunology
Immunology News, November 2002; Issue 9.6
Greaves
DR, and Gordon S
Macrophage-specific gene expression - current paradigms and future challenges.
International Journal of Hematology, 2002; 76: 6-15.
Angata T,
Kerr SC, Greaves DR, Varki NM, Crocker PR, Varki A
Cloning and characterisation of human Siglec-11. A recently evolved signalling
molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue
macrophage.
J
Biol Chem, 2002; 277: 24466-24474.
Lang R,
Rutschman RL, Greaves DR, Murray PJ
Autocrine deactivation of macrophages in transgenic mice constitutively expressing
IL-10 under control of the human CD68 promoter.
Journal of Immunology, 2002; 68: 3402-3411.
Balch SG, Greaves
DR, Gordon S, McKnight AJ.
Organization of the mouse macrophage C-type lectin (Mcl) gene and
identification of a subgroup of related lectin molecules.
European Journal of Immunogenetics 2002; 29: 61-64.
Garton KJ, Gough PJ,
Blobel CP, Murphy G, Greaves DR, Dempsey PJ, and Raines EW.
TACE (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).
J Biol Chem, 2001; 276: 37993-8001.
Gough PJ, Gordon S, Greaves
DR.The
use of human CD68 transcriptional regulatory sequences to direct high-level
expression of class A scavenger receptor in macrophages in vitro and in vivo.
Immunology. 2001; 103: 351-361.
Greaves DR and Gordon S.
Immunity, atherosclerosis and cardiovascular disease.
Trends in Immunity, 2001; 22: 180 -181.
Lucas AD, Chadwick N,
Warren BF, Jewell DP, Gordon S, Powrie F and Greaves DR.
The
transmembrane form of the CX3CL1 chemokine fractalkine is expressed
predominantly by epithelial cells in vivo.
American Journal of Pathology, 2001, 158: 855 - 866.
Hiltunen TP, Gough PJ, Greaves
DR,
Gordon S, and Ylä-Herttuala S.
Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a
naturally occurring splice variant that encodes a non-functional, dominant
negative form of the macrophage scavenger receptor.
Atherosclerosis, 2001, 154: 415-419.
Greaves DR, Häkkinen T,
Lucas AD, Liddiard K, Jones E, Quinn CM, Senaratne J, Green FR, Tyson K, Boyle
J, Shanahan C, Weissberg PL, Gordon S, and Ylä-Hertualla S.
The linked chromosome 16q13 chemokines MDC, fractalkine and TARC are expressed
in human atherosclerotic lesions.
Arteriosclerosis, Thrombosis and Vascular Biology, 2001, 21: 923-929.
Price SJ, Greaves DR, and Watkins
H.
Identification of novel functional variants in the human matrix
metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional
regulation.
Journal of Biological Chemistry, 2001, 276: 7549-7558.
Lucas AD and Greaves
DR
Macrophages, atherosclerosis and chemokines
Expert Reviews in Molecular Medicine, 2001,
2000 (top, next, home)
Tait SW, Reid EB, Greaves
DR,
Wileman TE, and Powell PP.
Mechanism of Inactivation of NF-kappa B by a Viral Homologue of Ikappa Balpha.
Signal-induced release of Ikappa Balpha results in binding of the viral
homologue to NF-kappa B.
Journal of Biological Chemistry, 2000; 275: 34656-34664.
Laukkanen J, Lehtolainen
P, Gough PJ, Greaves DR, Gordon S, and Ylä -Herttuala S.
Adenovirus-mediated gene transfer of a secreted form of human macrophage
scavenger receptor (SR-AI) inhibits modified low density lipoprotein
degradation and foam cell formation in macrophages.
Circulation, 2000; 101: 1091-1096.
Greaves DR and Schall
TJ.
Chemokines and myeloid cell recruitment
Microbes and Infection, 2000; 2: 331-336
Greaves DR and Schall
TJ.
Dendritic cells, T lymphocytes and chemokines.
In: Chemokines and Allergic Disease, M.E. Rothenberg, editor. Marcel Dekker,
Inc. New York, 2000. pp.191-208.
1999 (top, next, home)
Quinn CM, Catchpole I,
Wiles AP, El Shanawany T, Ford MJ, Gordon S. and Greaves DR.
The
human EIF4AI gene contains multiple enhancer elements that direct high-level
reporter gene expression in a wide range of mammalian cell lines.
Genomics, 1999; 62: 468-476.
Gough PJ, Greaves DR, Suzuki H,
Hakkinen T, Hiltunen MO, Turunen M, Ylä Herttuala S, Kodama T and Gordon,S.
Analysis of human Macrophage Scavenger Receptor (SR-A) expression in human
atherosclerotic lesions.
Arteriosclerosis, Thrombosis and Vascular Biology, 1999; 19: 461-471.
1998 (top, next, home)
Greaves DR, Quinn CM,
Seldin M and Gordon S.
Functional comparison of the murine macrosialin and human CD68 promoters in
macrophage and non macrophage cell lines.
Genomics, 1998; 54: 165-168.
Jones E, Quinn CM, See
CG, Montgomery DS, Ford MJ, Kölble K, Gordon S and Greaves DR.
The
linked human elongation Initiation Factor 4A1 (EIF4A1) and CD68 genes map to
chromosome 17p13.
Genomics, 1998; 53: 248-250.
Nolan K, Greaves DR, and
Waldmann H.
The human interleukin 18 gene, IL-18, maps to 11q22.2-22.3, closely
linked to the DRD2 gene locus and distinct from mapped IDDM loci.
Genomics, 1998; 51: 161-163.
Honda M, Akiyama H,
Yamada Y, Kondo H, Kawabe Y, Takeya M, Takahashi K, Suzuki H, Doi T, Sakamoto
A, Ookawara S, Mato, Gough PJ, Greaves DR, Gordon S, M, Kodama T
and Matsushita M.
Immunohistochemical evidence for a Macrophage Scavenger Receptor in Mato cells
and reactive microglia of Ischemia and Alzheimer's Disease.
Biochem. Biophys. Research Communications, 1998; 245: 734 - 740.
Gough PJ, Greaves DR, and Gordon
S.
An alternatively spliced form of the human Macrophage Scavenger Receptor mRNA
encodes a trans-dominant negative form of the receptor with an altered
C-terminal amino acid sequence.
Journal of Lipid Research, 1998; 39: 531 - 543.
Greaves DR, Gough PJ,
and Gordon S.
Recent progress in defining the role of scavenger receptors in lipid transport,
atherosclerosis and host defence.
Current Opinion in Lipidology 1998; 9: 425-432.
Greaves DR, Wang,W,
Dairaghi DJ, Caux,C, de St. Vis B, Franz-Bacon K, Rossi D, McClanahan T, Gordon S,
Zlotnik A and Schall TJ.
CCR6, a CC chemokine receptor which interacts with MIP-3alpha and is highly
expressed in human dendritic cells.
Journal of Experimental Medicine, 1997; 186: 837 - 844.
Bazan F, Bacon KB,
Hardiman G, Wang W, Soo K, Rossi D,
Greaves DR, Zlotnik A, and Schall TJ.
A new class of membrane-bound chemokine with a CX3C motif.
Nature, 1997; 385: 640 - 644.
Clarke S, Greaves DR, Chung L-P, Tree P and Gordon S.
The human lysozyme promoter directs reporter gene expression to activated
myelomonocytic cells in transgenic mice.
Proc. Natl. Acad. Sci. (USA), 1996; 93: 1434 -1438.
Dighe AS, Campbell D,
Hsieh C-S, Clarke S, Greaves DR, Gordon S, Murphy KM and
Schreiber RD.
Tissue specific targeting of cytokine unresponsiveness in transgenic mice.
Immunity, 1995; 3: 657 - 666.
Hanscombe O, Whyatt D,
Fraser P, Yannoutsos N, Greaves DR, Dillon N and Grosveld F.
Importance of globin gene order for correct developmental expression.
Genes and Development, 1991; 5: 1387 - 1394.
Greaves DR, Fraser P,
Vidal MA, Ropers D, Luzzatto L and Grosveld F.
A transgenic mouse model of sickle cell disorder.
Nature, 1990; 343:183 - 185.
Hanscombe O, Vidal M, Kaeda
J, Luzzatto L, Greaves DR and Grosveld F.
High- level, erythroid specific expression of the human alpha- globin gene in
transgenic mice and the production of human haemoglobin in murine erythrocytes.
Genes and Development , 1989; 3:1572 - 1581.
Talbot D, Collis P,
Antoniou M, Vidal M, Grosveld F, and Greaves DR.
A
dominant control region from the human beta - globin locus conferring
integration site- independent gene expression.
Nature, 1989; 338: 352 - 355.
Greaves DR, Wilson FD,
Lang G and Kioussis D.
Human CD2 3' flanking sequences confer high- level, T- cell specific, position
independent gene expression in transgenic mice.
Cell, 1989; 56: 979 - 986.
Blom van Assendelft M,
Hanscombe O, Grosveld F and Greaves DR.
The
beta - globin dominant control region activates homologous and heterologous
promoters in a tissue- specific manner.
Cell, 1989; 56: 969 - 977.
Grosveld F, Blom van
Assendelft M, Greaves DR and Kollias G.
Position-independent, high-level expression of the human beta- globin gene in transgenic
mice.
Cell, 1987; 51: 975 - 985.
Greaves DR and Borst P.
Trypanosoma brucei variant- specific glycoprotein gene chromatin
is sensitive to single strand specific endonuclease digestion.
Journal of Molecular Biology, 1987; 197: 471 - 483.
Borst P and Greaves
DR.
Programmed
gene rearrangements altering gene expression.
Science, 1987; 235: 658 - 667.
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http://dunn2.path.ox.ac.uk/~greaves/drgpubs.html |
Last updated 8 October 2007 |
Copyright David R. Greaves 2007 |