Recent Group Publications
LS, Brown MH, Barclay AN, Hatherley D. 2014. Signal-regulatory protein
alpha from the NOD mouse binds human CD47 with an exceptionally high
affinity-- implications for engraftment of human cells. Immunology; 143:61-7.
D, Lea SM, Johnson S, Barclay AN. 2014. Polymorphisms in the human
inhibitory signal-regulatory protein alpha do not affect binding to its
ligand CD47. J Biol Chem; 289:10024-8.
AN, Van den Berg TK. 2014. The interaction between signal regulatory
protein alpha (SIRPalpha) and CD47:
structure, function, and therapeutic target. Annual Review of Immunology; 32:25-50.
M, Metcalfe C, Barclay AN. 2013. Immunoregulation
through membrane proteins modified by reducing conditions induced by
immune reactions. Eur J Immunol 2013; 43:15-21.
JE, Ren J, Scott DJ, et al. 2013. Crystal
structure of signal regulatory protein gamma (SIRPgamma)
in complex with an antibody Fab fragment. BMC structural biology; 13:13.
D, Lea SM, Johnson S, Barclay AN. 2013. Structures of CD200/CD200
receptor family and implications for topology, regulation, and
evolution. Structure; 21:820-32.
M, Barclay AN. 2013. How do pathogens drive the evolution of paired
receptors? Eur J Immunol 2013; 43:303-13.
M, Aknin ML, Akkaya
B, Barclay AN. 2013. Dissection of agonistic and blocking effects of
CD200 receptor antibodies. PloS One; 8:e63325.
C., Cresswell, P,
Barclay, AN 2012. Interleukin-2
signalling is modulated by a labile disulfide bond in the CD132 chain
of its receptor
Open Biol January 2012 2:110036; doi:10.1098/rsob.110036
C., Cresswell, P,
Ciaccia, L, Thomas, B,
AN 2011. Labile
disulfide bonds are common at the leucocyte cell surface
Open Biol November
2011 1:110010; doi:10.1098/rsob.110010.
Foster-Cuevas M, Westerholt T,
Ahmed M, Brown MH, Barclay AN, Voigt S. 2011. Cytomegalovirus e127
Protein Interacts with the Inhibitory CD200 Receptor
Mukhopadhyay S, Plüddemann A, Hoe
JC, Williams KJ, Varin A, Makepeace K, Aknin ML, Bowdish DM, Smale ST,
Barclay AN, Gordon S. 2010
Immune inhibitory ligand CD200 induction by TLRs and NLRs limits
macrophage activation to protect the host from meningococcal septicaemia
Jiang, L., and A. N. Barclay. 2010.
Identification of Leukocyte Surface Protein Interactions by
High-Throughput Screening with Multivalent Reagents Immunology 129:55-61.
Akkaya, M., and A. N. Barclay.
2010. Heterogeneity in the CD200R paired receptor family. Immunogenetics 62:15-22.
Mihrshahi R, Barclay AN, Brown MH.
2009. Essential roles for Dok2 and RasGAP in CD200 receptor-mediated
regulation of human myeloid cells. J. Immunol. 183:
Zhang L, Stanford M, Liu J, Barrett
C, Jiang L, Barclay AN, McFadden G. 2009. Inhibition of macrophage
activation by the myxoma virus M141 protein (vCD200). J Virol. 83: 9602-7
Hatherley D, Graham SC, Harlos K,
Stuart DI, Barclay AN. 2009. Structure of signal-regulatory protein
alpha: a link to antigen receptor evolution. J. Biol. Chem. 284:
Barclay, A. N. 2009. Signal
regulatory protein alpha (SIRPalpha)/CD47 interaction and function. Curr Opin Immunol 21:47-52.
Jiang, L., and A. N. Barclay. 2009.
New assay to detect low-affinity interactions and characterization of
leukocyte receptors for collagen including leukocyte-associated Ig-like
receptor-1 (LAIR-1). Eur J Immunol 39:1167-1175.
Barclay AN and D Hatherley (2008) The counterbalance theory for
evolution and function of paired receptors Immunity 29,
Hatherley, D., S. C. Graham, J.
Turner, K. Harlos, D. I. Stuart, and A. N. Barclay. 2008. Paired Receptor
Specificity Explained by Structures of Signal Regulatory Proteins Alone
and Complexed with CD47. Molecular
Snelgrove, R. J., J. Goulding, A.
M. Didierlaurent, D. Lyonga, S. Vekaria, L. Edwards, E. Gwyer, J. D.
Sedgwick, A. N. Barclay, and T. Hussell. 2008. A critical function for
CD200 in lung immune homeostasis and the severity of influenza
Nat Immunol 9: 1074-1083.
Nettleship, J. E., J. Ren, N.
Rahman, N. S. Berrow, D. Hatherley, A. N. Barclay, and R. J. Owens.
2008. A pipeline for the production of antibody fragments for
structural studies using transient expression in HEK 293T cells. Protein
Expr Purif. 62(1):83-9
Adams, J. C., A. A. Bentley, M.
Kvansakul, D. Hatherley, and E. Hohenester. 2008. Extracellular matrix
retention of thrombospondin 1 is controlled by its conserved C-terminal
Cell Sci 121:784-795.
Hatherley, D., K. Harlos, D. C. Dunlop, D. I. Stuart, and A. N. Barclay. 2007. The structure of
the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory
receptor reveals a binding face reminiscent of that used by T cell
J. Biol. Chem. 282:14567-14575.
Hassan, N. J., S. J. Simmonds, N. G. Clarkson, S.
Hanrahan, M. J. Puklavec, M. Bomb, A. N. Barclay, and M. H. Brown.
2006. CD6 Regulates T-Cell Responses through Activation-Dependent
Recruitment of the Positive Regulator SLP-76. Mol. Cell. Biol. 26:6727-6738.
Barclay A.N. and Brown M.H. 2006. The SIRP family of
receptors and immune regulation. Nat
Rev Immunol 6: 457-464.