Marion H. Brown






Dr Marion H. Brown

Reader in Immunology
Sir William Dunn School of Pathology
University of Oxford
Oxford OX1 3RE, UK
Phone: (01865) 275595
Fax: (01865) 275591




















Selected Publications


1.         Margraf, S., et al., A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation. Immunology, 2015.

2.         Chappell, P.E., et al., Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. Structure, 2015. 23(8): p. 1426-36.

3.         Brown, M.H., CD6 as a cell surface receptor and as a target for regulating immune responses. Curr Drug Targets, 2015.

4.         Wilson, T.J., et al., Fine specificity and molecular competition in SLAM family receptor signalling. PLoS One, 2014. 9(3): p. e92184.

5.         Mihrshahi, R. and M.H. Brown, Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling. J Immunol, 2010. 185(12): p. 7216-22.

6.         Brown, M.H. and E. Lacey, A Ligand for CD5 is CD5. Journal of Immunology, 2010. 185(10): p. 6068-6074.

7.         Mihrshahi, R., A.N. Barclay, and M.H. Brown, Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. J Immunol, 2009. 183(8): p. 4879-86.

8.         Clarkson, N.G. and M.H. Brown, Inhibition and Activation by CD244 Depends on CD2 and Phospholipase C-{gamma}1. J Biol Chem, 2009. 284(37): p. 24725-34.

9.         Clarkson, N.G., et al., Direct and Indirect Interactions of the Cytoplasmic Region of CD244 (2B4) in Mice and Humans with FYN Kinase. J Biol Chem, 2007. 282(35): p. 25385-94.

10.       Hassan, N.J., et al., CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76. Mol Cell Biol, 2006. 26(17): p. 6727-38.

11.       Hassan, N.J., A.N. Barclay, and M.H. Brown, Frontline: Optimal T cell activation requires the engagement of CD6 and CD166. Eur J Immunol, 2004. 34(4): p. 930-40.

12.       Hutchings, N.J., et al., Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. J Biol Chem, 2003. 278(25): p. 22396-403.











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15th February, 2016