The aim of my DPhil is to characterize the role of NOD-like receptors in the pathogenesis of inflammatory bowel disease. In particular, my research is focused on analyzing the role of the NLR-triggered cytokine interleukin-1β in innate and T-cell driven model of disease. Moreover, I aim to assess how the NLR NOD2 is involved in the development of inflammatory bowel disease.
Coccia, M., Harrison, O.J., Schiering, C., Asquith, M.J., Becher, B., Powrie, F., Maloy, K.J. (2012). IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med. 27;209(9):1595-609. [PubMed]
Badami, E., Sorini, C., Coccia, M., Usuelli, V., Molteni, L., Bolla, A.M., Scavini, M., Mariani, A., King, C., Bosi, E., Falcone, M. (2011). Defective differentiation of regulatory FoxP3+ T cells by small-intestinal dendritic cells in patients with type 1 diabetes. Diabetes. 60(8):2120-4. [PubMed]
Baev, D.V., Caielli, S., Ronchi, F., Coccia, M., Facciotti, F., Nichols, K.E., and Falcone, M. (2008). Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice. J. Immunol. 181(2):869-77. [PubMed]