New Student Projects
Membrane proteins regulate cell
signalling and adhesion. Disruption of these functions are
frequently detected in cancer.
Through genetic manipulation, we have defined an important functional role of
E-cadherin in tumour development.
This project now aims to further define the regulatory functions of the
E-cadherin adhesion molecule in intestinal tumour growth.
Conditional genetic models combined with loss and gain of function will be
applied to the investigation of E-cadherin function in
the organoid stem cell culture model of intestinal
tumours. These experiments may lead to the identification of
therapeutic strategies that abrogate invasion and tumour metastasis.
Latest
Publication
Our latest publication is out:
An
Exon Splice Enhancer Primes IGF2:IGF2R Binding Site Structure and Function
Evolution (2012) Williams et al. Science (In Press).
Tumour
Growth Control Group (CRUK) - Sir William Dunn School of Pathology
Positions
and Studentship Places - Internal
DPhil Projects Available (available September 2013)
Membrane proteins regulate cell signalling and adhesion. Disruption of these functions are frequently detected in
cancer.
Through genetic manipulation, we have defined an important functional role of
E-cadherin in tumour development.
This project now aims to further define the regulatory functions of the
E-cadherin adhesion molecule in intestinal tumour growth.
Conditional genetic models combined with loss and gain of function will be
applied to the investigation of E-cadherin function in
the organoid stem cell culture model of intestinal
tumours. These experiments may lead to the identification of
therapeutic strategies that abrogate invasion and tumour metastasis.